BDNF (brain-derived neurotrophic factor)
8 views
Skip to first unread message
Swarfmaker
Sep 17, 2010, 1:30:57 PM9/17/10
to Tauopathies
Alzheimer's Prevented And Reversed With Natural Protein In Animal
Models
ScienceDaily (Feb. 9, 2009)
"Memory loss, cognitive impairment, brain cell degeneration and cell
death were prevented or reversed in several animal models after
treatment with a naturally occurring protein called brain-derived
neurotrophic factor (BDNF). The study by a University of California,
San Diego-led team – published in the February 8, 2009 issue of Nature
Medicine – shows that BDNF treatment can potentially provide long-
lasting protection by slowing, or even stopping the progression of
Alzheimer's disease in animal models... For these experiments, the
researchers injected the BDNF gene or protein in a series of cell
culture and animal models, including transgenic mouse models of
Alzheimer's disease; aged rats; rats with induced damage to the
entorhinal cortex; aged rhesus monkeys, and monkeys with entorhinal
cortex damage...."
http://www.sciencedaily.com/releases/2009/02/090208133135.htm
Axons Necessary For Voluntary Movement Regenerated
ScienceDaily (Apr. 9, 2009)
"For the first time, researchers have clearly shown regeneration of a
critical type of nerve fiber that travels between the brain and the
spinal cord and which is required for voluntary movement... "This
finding establishes a method for regenerating a system of nerve fibers
called corticospinal motor axons. Restoring these axons is an
essential step in one day enabling patients to regain voluntary
movement after spinal cord injury,"... This work builds on another
study from Tuszynski's laboratory, published in the February 8, 2009
issue of Nature Medicine, which reported that BDNF also exhibits
potential as a therapy for reducing brain cell loss in Alzheimer's
disease..."
http://www.sciencedaily.com/releases/2009/04/090406192229.htm
On January 07, 2009 11:02 AM Dr Mary Newport posted the following to
the "New Study: Brain starvation appears to trigger AD" topic:
"...There is a substance called BDNF (brain derived neurotrophic
factor) that is believed to be involved with this and it increase with
vigorous exercise and learning."
http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/4621036733?r=1701087833#1701087833
On February 15, 2009 01:30 PM RArmant post the following to the
"Ultimate Alzheimer's Cocktail" topic:
"Fish oil can help keep the arteries from blocking up. DHA and EPA
both drive down blood triglyceride level about equally. However DHA
appears to be important for the brain. It can help increase Brain-
derived neurotrophic factor(bdnf). Bdnf might help with brain
repair... My suggestion for Alzheimer's is to go with fish oil that
has a high DHA to EPA ratio such as Carlson's Super-DHA that contains
500 mgs of DHA and 100 mg of EPA per capsule."
http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/1891020913?r=4371031443#4371031443
There is also mention of BDNF in a post by vend95 on May 05, 2008 in
the "Promising Drug PRX-03140" topic:
"PRX-03140 is a novel, oral investigational drug candidate for
Alzheimer's disease. It is selective for the 5-HT4 receptor in the
brain and is believed to stimulate both acetylcholine production and
release - which enables symptomatic improvement in Alzheimer's
patients - and the alpha-secretase pathway - which may slow
Alzheimer's disease progression. Recent Phase 2a results indicated
that patients receiving daily oral 150 mg doses of PRX-03140 as
monotherapy for two weeks achieved a mean 3.6 point improvement on the
Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-cog)
versus a 0.9 point worsening in patients on placebo (p= 0.021). In
three Phase 1 trials and the Phase 2a trial, with more than 180
patients and healthy subjects, PRX-03140 has been well-tolerated. In a
14-day Phase 1b clinical trial, treatment with PRX-03140 resulted in
changes in brain wave activity in Alzheimer's patients that are
consistent with those seen in clinical trials with currently approved
drugs for Alzheimer's disease. In preclinical studies, PRX-03140 has
shown to improve cognitive function through increasing levels of
acetylcholine, and has led to increased levels of soluble amyloid
precursor protein (sAPP) and brain-derived neurotrophic factor (BDNF)
in regions of the brain known to be important for memory."
http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/3231069892?r=4751085103#4751085103
Post by neuroprof on May 04, 2009 01:04 PM:
"There is growing evidence to suggest that amino acids such as acetyl-
l-carnitine, l-tyrosine, and cysteine are critical to the aging brain
and may be crucial in the production of BDNFA (Brain-Derived
Neurotrophic Factor)."
http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/1891020913?r=90310869#90310869
Post by neuroprof on July 31, 2009 10:41 AM
"...In terms of other amino acids that may be good N-acetyl-l-cysteine
looks like it can help with the production of BDNF (brain-derived
neurotrophic factor)..."
http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/1891020913?r=362105861#362105861
Post by lucho on August 01, 2009 07:12 PM
"According to some trials and researches Mianserin and Remeron are the
only psychotropic drugs which are allowed for different dementias
because benzodiazepines and neuroleptics deplete some
neurotransmitters in the brain. Mianserin and Remeron also stimulate
BDNF and NGF (Nerve Growth Factor) release in the brain."
http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/34110941?r=262104961#262104961
Neural Stem Cells May Rescue Memory In Advanced Alzheimer's, Mouse
Study
Suggests
ScienceDaily (July 22, 2009)
"UC Irvine scientists have shown for the first time that neural stem
cells can rescue memory in mice with advanced Alzheimer's disease,
raising hopes of a potential treatment for the leading cause of
elderly dementia that afflicts 5.3 million people in the U.S... The
stem cells didn't improve cognition by becoming new neurons, nor did
they act by reducing the number of plaques and tangles. Rather, the
stem cells were found to have secreted a protein called brain-derived
neurotrophic factor, or BDNF. This caused existing tissue to sprout
new neurites, strengthening and increasing the number of connections
between neurons. When the team selectively reduced BDNF from the stem
cells, the benefit was lost, providing strong evidence that BDNF is
critical to the effect of stem cells on memory and neuronal
function... Diseased mice injected directly with BDNF also improved
cognitively but not as much as with the neural stem cells, which
provided a more long-term and consistent supply of the protein..."
http://www.sciencedaily.com/releases/2009/07/090720190726.htm
You can also do a search on ScienceDaily.com for BDNF
http://www.sciencedaily.com/search/?type=news&keyword=BDNF§ion=all&filename=&period=1825&sort=relevance
Models
ScienceDaily (Feb. 9, 2009)
"Memory loss, cognitive impairment, brain cell degeneration and cell
death were prevented or reversed in several animal models after
treatment with a naturally occurring protein called brain-derived
neurotrophic factor (BDNF). The study by a University of California,
San Diego-led team – published in the February 8, 2009 issue of Nature
Medicine – shows that BDNF treatment can potentially provide long-
lasting protection by slowing, or even stopping the progression of
Alzheimer's disease in animal models... For these experiments, the
researchers injected the BDNF gene or protein in a series of cell
culture and animal models, including transgenic mouse models of
Alzheimer's disease; aged rats; rats with induced damage to the
entorhinal cortex; aged rhesus monkeys, and monkeys with entorhinal
cortex damage...."
http://www.sciencedaily.com/releases/2009/02/090208133135.htm
Axons Necessary For Voluntary Movement Regenerated
ScienceDaily (Apr. 9, 2009)
"For the first time, researchers have clearly shown regeneration of a
critical type of nerve fiber that travels between the brain and the
spinal cord and which is required for voluntary movement... "This
finding establishes a method for regenerating a system of nerve fibers
called corticospinal motor axons. Restoring these axons is an
essential step in one day enabling patients to regain voluntary
movement after spinal cord injury,"... This work builds on another
study from Tuszynski's laboratory, published in the February 8, 2009
issue of Nature Medicine, which reported that BDNF also exhibits
potential as a therapy for reducing brain cell loss in Alzheimer's
disease..."
http://www.sciencedaily.com/releases/2009/04/090406192229.htm
On January 07, 2009 11:02 AM Dr Mary Newport posted the following to
the "New Study: Brain starvation appears to trigger AD" topic:
"...There is a substance called BDNF (brain derived neurotrophic
factor) that is believed to be involved with this and it increase with
vigorous exercise and learning."
http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/4621036733?r=1701087833#1701087833
On February 15, 2009 01:30 PM RArmant post the following to the
"Ultimate Alzheimer's Cocktail" topic:
"Fish oil can help keep the arteries from blocking up. DHA and EPA
both drive down blood triglyceride level about equally. However DHA
appears to be important for the brain. It can help increase Brain-
derived neurotrophic factor(bdnf). Bdnf might help with brain
repair... My suggestion for Alzheimer's is to go with fish oil that
has a high DHA to EPA ratio such as Carlson's Super-DHA that contains
500 mgs of DHA and 100 mg of EPA per capsule."
http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/1891020913?r=4371031443#4371031443
There is also mention of BDNF in a post by vend95 on May 05, 2008 in
the "Promising Drug PRX-03140" topic:
"PRX-03140 is a novel, oral investigational drug candidate for
Alzheimer's disease. It is selective for the 5-HT4 receptor in the
brain and is believed to stimulate both acetylcholine production and
release - which enables symptomatic improvement in Alzheimer's
patients - and the alpha-secretase pathway - which may slow
Alzheimer's disease progression. Recent Phase 2a results indicated
that patients receiving daily oral 150 mg doses of PRX-03140 as
monotherapy for two weeks achieved a mean 3.6 point improvement on the
Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-cog)
versus a 0.9 point worsening in patients on placebo (p= 0.021). In
three Phase 1 trials and the Phase 2a trial, with more than 180
patients and healthy subjects, PRX-03140 has been well-tolerated. In a
14-day Phase 1b clinical trial, treatment with PRX-03140 resulted in
changes in brain wave activity in Alzheimer's patients that are
consistent with those seen in clinical trials with currently approved
drugs for Alzheimer's disease. In preclinical studies, PRX-03140 has
shown to improve cognitive function through increasing levels of
acetylcholine, and has led to increased levels of soluble amyloid
precursor protein (sAPP) and brain-derived neurotrophic factor (BDNF)
in regions of the brain known to be important for memory."
http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/3231069892?r=4751085103#4751085103
Post by neuroprof on May 04, 2009 01:04 PM:
"There is growing evidence to suggest that amino acids such as acetyl-
l-carnitine, l-tyrosine, and cysteine are critical to the aging brain
and may be crucial in the production of BDNFA (Brain-Derived
Neurotrophic Factor)."
http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/1891020913?r=90310869#90310869
Post by neuroprof on July 31, 2009 10:41 AM
"...In terms of other amino acids that may be good N-acetyl-l-cysteine
looks like it can help with the production of BDNF (brain-derived
neurotrophic factor)..."
http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/1891020913?r=362105861#362105861
Post by lucho on August 01, 2009 07:12 PM
"According to some trials and researches Mianserin and Remeron are the
only psychotropic drugs which are allowed for different dementias
because benzodiazepines and neuroleptics deplete some
neurotransmitters in the brain. Mianserin and Remeron also stimulate
BDNF and NGF (Nerve Growth Factor) release in the brain."
http://alzheimers.infopop.cc/eve/forums/a/tpc/f/762104261/m/34110941?r=262104961#262104961
Neural Stem Cells May Rescue Memory In Advanced Alzheimer's, Mouse
Study
Suggests
ScienceDaily (July 22, 2009)
"UC Irvine scientists have shown for the first time that neural stem
cells can rescue memory in mice with advanced Alzheimer's disease,
raising hopes of a potential treatment for the leading cause of
elderly dementia that afflicts 5.3 million people in the U.S... The
stem cells didn't improve cognition by becoming new neurons, nor did
they act by reducing the number of plaques and tangles. Rather, the
stem cells were found to have secreted a protein called brain-derived
neurotrophic factor, or BDNF. This caused existing tissue to sprout
new neurites, strengthening and increasing the number of connections
between neurons. When the team selectively reduced BDNF from the stem
cells, the benefit was lost, providing strong evidence that BDNF is
critical to the effect of stem cells on memory and neuronal
function... Diseased mice injected directly with BDNF also improved
cognitively but not as much as with the neural stem cells, which
provided a more long-term and consistent supply of the protein..."
http://www.sciencedaily.com/releases/2009/07/090720190726.htm
You can also do a search on ScienceDaily.com for BDNF
http://www.sciencedaily.com/search/?type=news&keyword=BDNF§ion=all&filename=&period=1825&sort=relevance
Swarfmaker
Sep 17, 2010, 1:35:40 PM9/17/10
to Tauopathies
This is more about Parkinson's disease than tauopathies...
Finnish Scientists Discover Nerve Growth Factor With Therapeutic
Potential In Parkinson's Disease
ScienceDaily (Aug. 30, 2009)
"...two new nerve growth factors. MANF (mesencephalic astrocyte-
derived neurotrophic factor) is released from glial cells in the
midbrain and is a member of the same growth factor family as CDNF,
another growth factor that Saarma's team have investigated. A
University of Helsinki team led by Professor Raimo K. Tuominen
discovered that in the experimental PD model, MANF and CDNF injections
into the brain prevented dopamine nerve destruction caused by nerve
poison and to some extent even restored the function of damaged cells
in rats..."
http://www.sciencedaily.com/releases/2009/08/090828103924.htm
Finnish Scientists Discover Nerve Growth Factor With Therapeutic
Potential In Parkinson's Disease
ScienceDaily (Aug. 30, 2009)
"...two new nerve growth factors. MANF (mesencephalic astrocyte-
derived neurotrophic factor) is released from glial cells in the
midbrain and is a member of the same growth factor family as CDNF,
another growth factor that Saarma's team have investigated. A
University of Helsinki team led by Professor Raimo K. Tuominen
discovered that in the experimental PD model, MANF and CDNF injections
into the brain prevented dopamine nerve destruction caused by nerve
poison and to some extent even restored the function of damaged cells
in rats..."
http://www.sciencedaily.com/releases/2009/08/090828103924.htm
Reply all
Reply to author
Forward
0 new messages