Age related changes in unsuppressed water signal
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Bartosz Kossowski
May 21, 2020, 4:33:38 AM5/21/20
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Dear All,
one of my colleagues asked me how do I correct for changing water concentration related to age of participants (8-40 y/o). I said that the method I use is based on a segmentation into 3 tissue classes and the water content is estimated based on the literature values respective for GM, WM and CSF.
Do You agree that the values may vary with age? So is there any correction factor available?
What about T2 attenuation. Should I care about "0.7" water/metabolite signal ratio?
I am very curious and I look forward to hearing from You!
Bartosz Kossowski
Bartosz Kossowski
May 27, 2020, 7:51:05 AM5/27/20
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It looks like I need to answer myself :)
White matter water concentration of 35,880M seems to be taken from the paper from 1994 (https://www.sciencedirect.com/science/article/abs/pii/0730725X94900889?via%3Dihub). Indeed, authors compared different age groups and did not find the difference between adolescents, adults and elders. However, the sample size wasn't very big and there have been probably many technical improvements since then. I didn't manage to find any recent paper.
White matter water concentration of 35,880M seems to be taken from the paper from 1994 (https://www.sciencedirect.com/science/article/abs/pii/0730725X94900889?via%3Dihub). Indeed, authors compared different age groups and did not find the difference between adolescents, adults and elders. However, the sample size wasn't very big and there have been probably many technical improvements since then. I didn't manage to find any recent paper.
Isn't it fascinating? :)
B.
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