- Blood has a lot of Cations
- Blood has a lot of Anions
Total charge of Anions = Total Charge of Cations
So
Na + K + Unmeasured Cations = HCO3 + Cl + unmeasured Anions
Rearranging
Na + K - (HCO3 + Cl) = Unmeasured Anions - Unmeasured CationsAnion Gap = Unmeasured Anions - Unmeasured CationsAnion Gap = (Na + K) - (HCO3 + Cl)
Note that some books ignore the value of Calcium and calculate Anion Gap as Na - (HCO3+Cl)
- Unmeasured Anions: Means all anions other than HCO3 and Cl ----> lactate, phosphate, ketoacids , Albumin, Ethylene Glycol etc
- Unmeasured Cations: Means Ca, Lithium, Globulin
So
Anion Gap is Increased in-
Conditions with Increased Unmeasured Anions
- Diabetic Ketoacidosis
- Uremia
- Lactic Acidosis
- Conditions with Decreased Unmeasured Cations
- Hypocalcemia
Anion Gap is decreased in
- Conditions with Decreased Unmeasured Anions
- Hypoalbuminaemia (theoritically)
- Conditions with Increased Unmeasured Cations
- Increase in Globulin (multiple Myeloma)
-
Lithium Toxicity
Easy way to solve MCQs
1. Check what is decreased / Increased
If that is Na / K / HCO3 / Cl it is Normal Anion Gap Metabolic Acidosis (also called
NAGMA). The matter is settled. No doubt about that. Vomitting, Diarrhoea, Renal Tubular Acidosis etc come here
2. If there is an increase in Unmeasured Anions (lactate etc)
It is High Anion Gap Metabolic Acidosis (
HAGMA)
3. If there is a decrease in Unmeasured Cations (Globulin etc)
It is High Anion Gap Metabolic Acidosis (
HAGMA)
4. If there is an increase in Unmeasured Cations (lactate etc)
It is Low Anion Gap Metabolic Acidosis (
LAGMA)
5. If there is a decrease in Unmeasured Anions
It is Low Anion Gap Metabolic Acidosis (
LAGMA)
Any doubts !!!
Ask here
http://bruno.penandscale.com/2006/10/anion-gap-hagma-lagma-and-nagma.html
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