"According to Linda Oliver-Perrier, The Center's spokesperson for their
Life Sciences group, "The details of the disruptive process are somewhat
complex and not conducive for explanation in a press release."
Simply put it has yet to be verified. Another could've, would've,
should,ve,
Bottom line is they want money.
On Fri, 18 Dec 2009 19:28:38 -0800, PeterB - Original wrote:
Utter bullshit...
http://leftbrainrightbrain.co.uk/?p=3702
It has some excellent hooks to convince the casual reader. They
present themselves as very successful in a separate field, and claim
they stumbled upon a very important idea: that substances within the
body exist in pairs. When these pairs are imbalanced, homeostasis is
broken, resulting in chronic disease.
Autism, according the “The Center” is caused by an imbalance, or lack
of homeostasis, in glycine and glutamate.
How does this cause the condition we know as autism? Unexplained.
Somehow, glycine and glutamate “control the rate of cellular
absorption”. Absorption of what? Unexplained. How does this cause
autism? Unexplained.
But, it all sounds nice and official.
How do glycine and glutamate get away from “homeostasis”? Vaccines. I
know, you are stunned that vaccines are implicated in causing autism.
The “think tank” looked at the work of Andrew Wakefield and came away
with the idea that MMR causes autism. What’s in an MMR shot?
Hydrolized gelatin, which, in turn, contains glycine.
Of course, this is an important finding and controversial:
“Undoubtedly, this finding based on the application of the model for
homeostasis will cause immense controversy. Our Life Sciences group is
prepared to meet with members of the scientific community to explain
the model as well as the variables that create the ‘perfect storm’
that results in autism.”
The controversy statement is a good one to make this appear real to
many readers.
Perhaps the “think tank” could have done a bit more research into the
autism alternative medical community. What are two of the most common
supplements recommended by DAN!? TMG and DMG—trimethyl and
dimethyl….glycine. Pure glycine is a supplement, sometimes recommended
in the autism alt-med world (also here). But, somehow, we are supposed
to believe that a small amount in an MMR shot causes the lifelong
condition we call autism?
While it appears easy for some to sit back and point out that this
press release, this homeostasis model of glycine and glutathione, is
junk science, we must also recognize that it is not easy for everyone.
The press release is wrapped in just enough jargon to make a
convincing argument for many readers.
Read more: http://leftbrainrightbrain.co.uk/?p=3702#ixzz0a9MQ0ZW5
You've never had a science course!
Mysticism?
Wrong. I have had a lot of science courses.
It doesn't show.
I have not shown it. The fact remains that the anti-vaccination issue
is really political.
College Science?
Lots?
None!
More than you, and I am taking courses online, just for the joy of
learning.
I know I'll regret it, but please clarify.
No matter what proof of safety and efficacy is shown, the anti-vac
liars (get your mirror out) will never accept it.
"I've tried to pin such people down time and time again to answer just
what it would take in terms of scientific studies and evidence or in
terms of what "toxins" would have to be removed to convince them that
vaccines are sufficiently safe that they will have their children
vaccinated? Inevitably, the answer involves levels of evidence that
are beyond what can be practically or ethically obtained; i.e., a
randomized, double-blind clinical study of vaccinated versus
unvaccinated children (which would be totally unethical) or an
underpowered, poorly designed retrospective study (which would be
prone to false positives or could be dismissed by anti-vaccinationists
as inadequate if it were negative). That's because, its denials
notwithstanding, it is always and has always been all about the
vaccines, period, end of story."
http://scienceblogs.com/insolence/2009/12/crank_magnetism_at_a_young_age_anti-vacc.php
And, that is it, in a NUTshell.
Posted a site from his buddy.
About Orac
Orac is the nom de blog of a humble pseudonymous surgeon/scientist
with an ego just big enough to delude himself that someone, somewhere
might actually give a rodent's posterior about his copious verbal
meanderings, but just barely small enough to admit to himself that few
probably will. That Orac has chosen his pseudonym based on a rather
cranky and arrogant computer shaped like a clear box of blinking
lights that he originally encountered when he became a fan of a nearly
30 year old British SF television show whose special effects were
renowned for their BBC/Doctor Who-style low budget look, but whose
stories nonetheless resulted in some of the best, most innovative
science fiction ever televised, should tell you nearly all that you
need to know about Orac. (That, and the length of the preceding
sentence.)
Respectful Insolence™ is a repository for the ramblings of the
aforementioned pseudonymous surgeon/scientist concerning medicine and
quackery, science and pseudoscience, history and pseudohistory,
politics, and anything else that interests him (or pushes his
buttons). Orac's motto is: "A statement of fact cannot be
insolent." (OK, maybe it can be just a little bit insolent. Sometimes.
OK, fairly often. Orac tries to keep his insolence respectful most of
the time, but readily admits that he sometimes fails in cases of
obvious quackery and pseudoscience, responding to personal attacks on
him, examining poor critical thinking skills, bigotry or racism, and
just general plain stupidity. When the stupidity to which Orac is
responding reaches a certain very high level, he just can't help it
and makes no apologies. You will know this is happening when Orac uses
the phrase "the stupid, it burns" or some variant thereof.
Finally, Orac's "real" identity is more or less an open secret among
some parts of the blogosphere, but he nonetheless keeps using the Orac
pseudonym because (1) he doesn't want his blog to be the first thing
that comes up when patients Google his "real" name; (2) he has a long
history on the Internet under this particular pseudonym; and (3) he
likes the persona that the "Orac" pseudonym allows him to take on.
Indeed, even if Orac ever decides to ditch the whole anonymity thing,
he will likely retain the pseudonym and simply place a link to his
faculty page somewhere on the blog.
Disclaimer
This is a personal web log, reflecting the sometimes prickly opinions
of its author. Statements on this blog do not represent the opinions
of anyone other than the author. They most definitely do not represent
the opinions or position of the author's hospital, university, cancer
institute, surgical practice, partners, or research colleagues. The
information on this blog is intended for discussion and entertainment
purposes only and not as recommendations about how to diagnose or
treat illnesses. Any personal medical issues the reader may have
should be referred to the reader's physician. If the reader freely
chooses to follow the opinion of a pseudonymous blogger like the
author (who has also not done a proper history or physical examination
and whose credentials cannot be verified) over that of his or her own
personal physician, it is the reader's decision alone, for which the
reader must bear full responsibility.
Medical science does not produce "proof," it produces evidence. A
viewpoint based on the available evidence is not a lie. You hide
behind the suggestion that there is "proof" for one simple reason:
you cannot afford to debate the evidence.
> "I've tried to pin such people down time and time again to answer just
> what it would take in terms of scientific studies and evidence or in
> terms of what "toxins" would have to be removed to convince them that
> vaccines are sufficiently safe that they will have their children
> vaccinated? Inevitably, the answer involves levels of evidence that
> are beyond what can be practically or ethically obtained; i.e., a
> randomized, double-blind clinical study of vaccinated versus
> unvaccinated children (which would be totally unethical)...
Your assertion that use of proper scientific study to determine the
efficacy of vaccine as being "unethical" is indefensible, for obvious
reasons. If evidence of vaccine effectiveness and safety cannot be
derived under clinically controlled conditions, it can't be ethical to
use such medicine in the first place. There is no way around it.
> or an
> underpowered, poorly designed retrospective study (which would be
> prone to false positives or could be dismissed by anti-vaccinationists
> as inadequate if it were negative). That's because, its denials
> notwithstanding, it is always and has always been all about the
> vaccines, period, end of story."
Changes in disease demographics during periods of history when
vaccines were mostly unavailable (in fact, non existent) are even
worse, as the possibility of correlation to vaccine is impossible.
That is why the quality of evidence is so revealing when reviewing
vaccine claims.
> http://scienceblogs.com/insolence/2009/12/crank_magnetism_at_a_young_...
>
> And, that is it, in a NUTshell.
I still don't understand your comment about the issue of vaccine being
"political."
=================================================
What on earth are you trying to discuss? Medicines? or Vaccines?
How can anyone answer your assertions when you don't even know what you
are talking about.
-------------------------------------------------------------------------
You were not being addressed, moron. This was specifically meant for
the other dipwit.
You left out the parts where he is a NIH funded cancer researcher,
surgical oncologist and academician.
However,
A/K/A facts.
A
> viewpoint based on the available evidence is not a lie.
When that viewpoint has been shown not to be based on facts it is.
You hide
> behind the suggestion that there is "proof" for one simple reason:
> you cannot afford to debate the evidence.
Evidence, i.e. facts, is not a subject for debate. Something is either
factual or not.
> > "I've tried to pin such people down time and time again to answer just
> > what it would take in terms of scientific studies and evidence or in
> > terms of what "toxins" would have to be removed to convince them that
> > vaccines are sufficiently safe that they will have their children
> > vaccinated? Inevitably, the answer involves levels of evidence that
> > are beyond what can be practically or ethically obtained; i.e., a
> > randomized, double-blind clinical study of vaccinated versus
> > unvaccinated children (which would be totally unethical)...
>
> Your assertion that use of proper scientific study to determine the
> efficacy of vaccine as being "unethical" is indefensible, for obvious
> reasons.
Wrong. You have no clue as to why the statement I posted is absolutely
true.
If evidence of vaccine effectiveness and safety cannot be
> derived under clinically controlled conditions, it can't be ethical to
> use such medicine in the first place. There is no way around it.
Sure there is. You just do not want any circumstance where the answer
involves levels of evidence that are beyond what can be practically or
ethically obtained.
> > or an
> > underpowered, poorly designed retrospective study (which would be
> > prone to false positives or could be dismissed by anti-vaccinationists
> > as inadequate if it were negative). That's because, its denials
> > notwithstanding, it is always and has always been all about the
> > vaccines, period, end of story."
>
> Changes in disease demographics during periods of history when
> vaccines were mostly unavailable (in fact, non existent) are even
> worse, as the possibility of correlation to vaccine is impossible.
> That is why the quality of evidence is so revealing when reviewing
> vaccine claims.
>
> >http://scienceblogs.com/insolence/2009/12/crank_magnetism_at_a_young_...
>
> > And, that is it, in a NUTshell.
>
> I still don't understand your comment about the issue of vaccine being
> "political."-
And, you never will.
Well, there is more proof that you have no desire to discuss. I won't
even bother to try.
>
>
>
> > -------------------------------------------------------------------------
>
> > > or an
> > > underpowered, poorly designed retrospective study (which would be
> > > prone to false positives or could be dismissed by anti-vaccinationists
> > > as inadequate if it were negative). That's because, its denials
> > > notwithstanding, it is always and has always been all about the
> > > vaccines, period, end of story."
>
> > Changes in disease demographics during periods of history when
> > vaccines were mostly unavailable (in fact, non existent) are even
> > worse, as the possibility of correlation to vaccine is impossible.
> > That is why the quality of evidence is so revealing when reviewing
> > vaccine claims.
>
> > >http://scienceblogs.com/insolence/2009/12/crank_magnetism_at_a_young_...
>
> > > And, that is it, in a NUTshell.
>
> > I still don't understand your comment about the issue of vaccine being
> > "political."- Hide quoted text -
>
> - Show quoted text -- Hide quoted text -
Disbarred Comic,
We've already been through this. Over a year ago
you admitted you had never had a college science
course. Were you lying then or are you lying now?
"...the deceitful words of Mark S. Probert, disbarred by
the New York Supreme Court in November, 1992."
http://www.humanticsfoundation.com/propagandistprobert.html
That's right, run away. You're good at that.
I never said that, because it is not true. If you want to spread that
lie, I suggest that you find it, and post a link to it.
Otherwise, I suggest that you not repeat it.
I never run. You are delusional, and need a way to discredit me, since
I have you nailed four square.
You just did, above. And you always have when confronted with your
logical fallacies, knowing they can't be defended.
> > > > > derived under clinically controlled conditions, it can't be ethical to
> > > > > use such medicine in the first place.
> You are delusional, and need a way to discredit me, since
> I have you nailed four square.
I need a way to discredit you? No. You do that all by yourself.
Wrong. I know that they can be defended, and readily so, but, with
your torturing of logic, creation of idiotsyncratic meanings, and your
other tactics, there is no point in doing so.
> > > > > > derived under clinically controlled conditions, it can't be ethical to
> > > > > > use such medicine in the first place.
> > You are delusional, and need a way to discredit me, since
> > I have you nailed four square.
>
> I need a way to discredit you? No. You do that all by yourself.-
Only in your delusional "mind", for want of a better word.
But your actions prove otherwise. You say you care about the truth
but cannot defend your own claims, proving that you lie.
> , but, with
> your torturing of logic, creation of idiotsyncratic meanings, and your
> other tactics, there is no point in doing so.
That is a very poor defense for not defending your claims. It appears
I am your only audience. What about those you claim you are here
trying to protect? Don't they deserve to see your "proof?"
When the glutathione level is low, it causes a multitude of problems
with some serious stress on the cells which is called "Oxidative
stress"
Oxidative stress is a lot like taking an apple and peeling away the
skin. Leave the apple out for an hour and it will turn brown. But
leave the apple out for a month and it will decay. This is what
happens to the cells in the body if they are not protected with
glutathione. Glutathione is like an apple peel to cells.
Also, glutathione is an antioxidant. Antioxidants are things like
vitamin A, D, C, E and few other things that do include glutathione to
the list.
The problem though, is that glutathione can only be made successfully
in the body by combining those three amino acids.
When those amino acids do not bind properly, they begin to saturate
the body in excessive amounts causing an oversupply or in some cases
becoming depleted because of what I explain next.
Remember, 2 of the amino acids are in many vaccinations. this is where
I think the body is trained to think that these amino acids are like a
virus and instead of binding as they should, the body thinks they are
a virus like chemical and try to get rid of them.
However, because there is no real virus, the body becomes confused and
sends wrong counter signals in an effort to correct itself. This is
where the body becomes imbalanced with amino acids and vitamins. A
body that is balanced with proper nutrients and vitamins, is known as
Homeostasis also known as equilibrium.
If you actually look at your kid's blood tests, you will see a range
for almost every test performed. The RBC, vitamin levels, etc, all
have to be in perfect balance or else this can indicate a problem to
the doctor if the levels of anything is either too high or too low.
The same is true for amino acid levels. There's about 22 amino acids.
somewhere around 10 of them come from food, the other 12 have to be
manufactured in the body. All amino acids come from the protein in our
food.
Many autistic kids are allergic to the two proteins called gluten and
casein. Both of them contain glutamate.
In addition, Monosodium glutamate which is MSG, is sometimes
manufactured from gluten. Today, a lot of MSG comes from seaweed
because it's cheaper to make. Either way, MSG is in a lot of foods as
well and hidden as "yeast extract", "Natural flavors", " hydrolyzed
protein" and many more alternative names. Even on labels that say "No
MSG". It's a lie that's allowed by the FDA as long as the alternative
is listed.
Again, glutamate and glycine is in several vaccines. This may be where
the body learns to attack glutamate and glycine from certain foods.
But then there's one more big question. If amino acids are in foods
naturally, then why would it be harmful in a shot in the arm? That one
is really easy to answer.
Amino acids from food is passed through the digestive tract where it
is normally regulated by the liver, kidneys, etc. When injected in the
arm, it never has a chance to be regulated and then has to rely on
other parts of the body to decide what to do with it.
Vaccines work at protecting us from harmful viruses because of the way
they are administered. Our body learns how to recognize them from
vaccines and then will attack the virus later on in life if we ever
encounter it.
So then why would amino acids be in there? It's inevitable that they
too will do the same thing.The body becomes confusingly alert to foods
that contain the same amino acids.
Amino acids are the building blocks to life. They are needed to make
the brain function properly as well as many other functions. Glutamate
and glycine very specifically are well known in the scientific
community to be responsible for how the brain function and processes
thoughts and remembers things.
So again, why are these two amino acids in vaccines?
It took me 5 months to narrow it down to this, but i think I'm on to
the real cause of, at least, my daughter's autism. If I'm correct,
then it should be an easier thing to understand how to successfully
reverse it.
If you take a look at how certain autism treatments work for some, but
not for others, and yet there is no real explanation, I honestly
believe that everyone is missing the one thing in common; and that's
how the amino acid levels are affected from treatments.
Remember that oxidative stress thing I explained? Well damaged cells
also cause inflammation to them. Basically, the cells swell up like
balloons. This is why HBOT therapy works for some. HBOT compresses the
cells and allows the body to temporarily function properly by
assisting certain amino acids to do their work.
There are several medication that have a direct affect on glutamate
levels. Take valtrex for example. Why do some autistic kids benefit
from valtrex when they never text positive for viral infections? Do
you know the Evan story? Valtrex directly affects the glutamate and
glycine levels.
Depending on the current homeostasis of the autistic child, this also
determines of certain treatments are going to work or not.
Also remember too, not all autism cases are from environmental factor.
There still is and may always be the genetic version of it. And even
with the environmental version, I still believe that certain genetics
still play a major role too.
Have you ever heard of some kids with autism that get high fever,
temporarily acting typical? I know of some cases where the child
spikes a high fever and then talks perfectly normal, even if they
don't normally use words. It's very strange, and only lasts as long as
the fever does and also does not happen in all cases?
High fevers are called Hyperthermia. Not Hypo, by Hyper.
So then what causes this you are wondering? I read a scientific study
that says that when the body becomes hyperthermic, it goes into a
survival state and tries to protect the major organs by, you guessed
it, sending mega doses of glutamate and other certain amino acids to
the brain in an effort to protect it.
This effort to protect it, just happens to be the normal range of
amino acids of a typical person. But because the autistic child has
unbalanced levels of amino acids, this natural survival technique
creates a normal range in the body that parents get to see as a little
miracle of speech.
Part 2
One other thing to note about low glutathione levels is that the liver
depends on normal levels of this great antioxidant otherwise, the
liver cannot detoxify as it should.
This may be where mercury poisoning comes into play for some autistic
children. If the liver can't get the junk out, it will instead store
it in the body. Mercury, lead, and other toxic metals will only float
around in the blood for so long until they begin to attach to organ
tissue like in the brain.
Glutathione is actually like a sticky substance that grabs excessive
amounts of toxins and delivers them to exit points in the body by a
binding process.
Alcoholics typically have low glutathione levels before their liver is
affected. It's not the liver that gets damaged first, but instead,
it's the glutathione levels. The same is true for people that abuse
certain medications. Acetaminophen is a great example of how a pill
can lower glutathione levels.
Because autism is so complex, not only should the glutamate and
glycine in vaccines be considered as a trigger to autism (glutathione
is made in the body by combining glutamate, glycine and cysteine), but
medications used to treat ear infections in children, as well as
Tylenol and Motrin.
The cascading assault of environmental becomes detrimental to a
developing body/mind in certain children with a certain genetic
makeup.
Perhaps genetics has a lot to do with autism, but scientific research
cannot pinpoint any conclusive evidence that is consistent to offer
proof that genetics is a factual cause.
Even the great chromosome 15q baffles researchers from one case to the
next. If 15% of autism has to do with the C 15q, in contrast there is
also evidence that supports how amino acids also have a strong impact
on not only genes themselves, but the entire chromosome.
And how about those chromosomes? Is there really any evidence that can
show the impact on them during the fetal development process and how
environmental impacts like the flu shot, heart burn medication and
delivery pain medications, along with HEP B at birth, and the vitamin
K shot all have to do with the genetic makeup of the child?
Let's not forget Dad before conception of his child as well? What was
he up to before the child was conceived? Medications, drugs, lack of
sunlight, poor diet, etc?
There's hundreds of possibilities, and no solid answers. But the most
thing in common with all of this is the glutathione levels in autistic
kids. If 83% of autistic kids have low glutathione levels and 15% have
the chromosome 15q duplication, then that only leaves 2% of autism
cases unanswered.
---------------
J Neuroimmunol. 2009 Dec 23. [Epub ahead of print]
Oxidative stress in Egyptian children with autism: relation to
autoimmunity.
Mostafa GA, El-Hadidi ES, Hewedi DH, Abdou MM.
Department of Pediatrics, Faculty of Medicine, Ain Shams University,
Cairo, Egypt.
We are the first to study the relationship between oxidative stress
(by measuring plasma F2-isoprostane, as a marker of lipid
peroxidation, and glutathione peroxidase, as an antioxidant enzyme)
and autoimmunity (as indicated by serum antineuronal antibodies) in a
group of 44 Egyptian autistic children and 44 healthy matched-
children. Our results showed that oxidative stress was found in 88.64%
of autistic children. Oxidative stress, resulting from elevated plasma
F2-isoprostane and/or reduced glutathione peroxidase, had significant
risk for antineuronal positivity, which was found in 54.5% of autistic
children, (odds ratio: 12.38 and 6.43, respectively, confidence
interval: 1.37-112.10 and 1.21-34.19, respectively). Conclusions: the
strong association between oxidative stress and autoimmunity in
autistic children may indicate the possible role of oxidative stress,
through induction of autoimmunity, in some autistic patients.
Therefore, studies considering the role of antioxidants and
immunotherapy in amelioration of autistic manifestations are
recommended. Copyright © 2009 Elsevier B.V. All rights reserved.
PMID: 20036015 [PubMed - as supplied by publisher]
The degree of thought you've put into this is impressive. The notion
that impaired amino acid metabolization could vector against gene
expression (especially in susceptible individuals) to produce disease
would have been a strange notion a decade or so ago, but thanks to the
new science of nutrigenics, that is no longer the case.
================================================
Could you explain "nutrigenics" or is it "nutrAgenics" to me please?
Thanks.
Sorry, the correct word is "nutrigenomics." Overview at
http://jn.nutrition.org/cgi/content/full/134/9/2434S or you might like
the wikipedia entry.
Thanks. You may also be interested to read about how genes can be
affected postnatal.
ScienceDaily (Jan. 5, 2010) — Scientists have long eyed mutations in a
gene known as DISC1 as a possible contributor to schizophrenia and
mood disorders, including depression and bipolar disorder. Now, new
research led by Johns Hopkins researchers suggests that perturbing
this gene during prenatal periods, postnatal periods or both may have
different effects in mice, leading to separate types of brain
alterations and behaviors with resemblance to schizophrenia or mood
disorders.
http://www.sciencedaily.com/releases/2010/01/100105095853.htm
My best friend's twin is schizophrenic and, of course, conventional
meds barely keep him together; plus one such drug made him diabetic.
Thanks for the link.
ZZzz,
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