Researchers Found Animal Virus in Pig Heart Transplanted Into Man Who Later Died

[Leroy N. Soetoro]

https://www.complex.com/life/a/cmplxjoshua-espinoza/man-who-died-after-
pig-heart-transplant-reportedly-carrying-animal-
virus?bfsource=relatedmanual

Researchers may be one step closer to determining what killed David
Bennett Sr.—the first-ever recipient of genetically modified pig heart.

The 57-year-old Maryland man underwent the experimental surgery back in
January, after he was deemed a bad candidate for a human heart transplant
or artificial heart pump. During the procedure, doctors noticed Bennett’s
aorta was beginning to come apart, so they implanted a graft and stent to
prevent further complications. Other than the artery incident, the surgery
was initially deemed a success; however, Bennett began experiencing severe
health problems just weeks after surgery.

According to USA Today, the man’s recovery was far from smooth. Doctors
reportedly had to perform not one, but two surgeries on his abdomen to
treat an intestinal infection. He was later prescribed a mix of
antibiotics, antiviral medication, and an immune-boosting treatment, but
he ultimately died in March after his pig heart became swollen with fluid
and stopped functioning.

On Thursday, researchers confirmed they had found an animal virus harbored
inside the pig heart Bennett had been carrying for months. It’s unclear if
the virus—called porcine cytomegalovirus—was the cause of Bennett’s death,
as they found no signs that the organ had caused active infection in the
patient. Doctors also said there were no signs that the pig organ was
being rejected by Bennett’s body.

Researchers say the pig that provided the heart was considered healthy,
and was subjected to a variety of tests ordered by the Food and Drug
administration. Revivicor, the biotech company that raised the animal, has
not commented.

“What was the virus doing, if anything, that might have caused the
swelling in his heart?” said Dr. Bartley Griffith, the surgeon who
performed the historic transplant. “Honestly we don’t know.”


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