Nando Ronteltap <
nando_r...@live.nl> wrote:
> The flu shot, in the current situation of pandemic covid, is also going
> to kill you, because you get the antibody dependent enhancement of
> disease for flu too now.
>
Cite?
There were concerns about ADE with potential COVID vaccines, but that
doesn’t seem to have happened. This more prospective view from late 2020:
“SARS-CoV immunization studies in animal models have thus produced results
that vary greatly in terms of protective efficacy, immunopathology and
potential ADE, depending on the vaccine strategy employed. Despite this,
vaccines that elicit neutralizing antibodies against the S protein reliably
protect animals from SARS-CoV challenge without evidence of enhancement of
infection or disease71,72,73. These data suggest that human immunization
strategies for SARS-CoV-2 that elicit high neutralizing antibody titres
have a high chance of success with minimal risk of ADE. For example,
subunit vaccines that can elicit S-specific neutralizing antibodies should
present lower ADE risks (especially against S stabilized in the prefusion
conformation, to reduce the presentation of non-neutralizing epitopes8).
These modern immunogen design approaches should reduce potential
immunopathology associated with non-neutralizing antibodies.”
https://www.nature.com/articles/s41564-020-00789-5
This is outside my wheelhouse, but I particularly recall the importance of
locking spike into a prefusion conformation.
At 1:01:17 this conformational lock related to avoiding ADE is discussed in
this MEDCRAM video by someone not in touch with subjectivity:
https://youtu.be/pp-nPZETLTo
So maybe making antibodies focused on spike that doesn’t undergo
conformation change keeps ADE from happening. She had discussed the work of
Jason McLellan earlier in the video on using two prolines to lock the thing
down.
Oh wait there’s Super Colon Blow with even more fiber:
https://www.pnas.org/doi/10.1073/pnas.2110105119
“The ability of preS-HexaPro in inducing high levels of Th1-biased T cell
immune response would also eliminate the antibody-dependent enhancement
(ADE), a concern that has been raised in CoV vaccine development (32, 33).”
From a paper starting out saying: “The emergent severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants complicate the battle to halt
the coronavirus disease 2019 (COVID-19) pandemic. The currently approved
vaccines typically express native full-length S or preS-2P. Here, we show
that HexaPro is superior to 2P or the native full-length S protein as a
SARS-CoV-2 vaccine immunogen. HexaPro is expressed more efficiently and
induces more robust SARS-CoV-2 specific antibody and Th1-biased T cell
immune responses. Antibodies induced by HexaPro also neutralize SARS-CoV-2
variants two- to fourfold more efficiently than those induced by preS-2P.
By comparing different immunization doses, we found that HexaPro is more
immunogenic and protective than 2P. This work highlights the importance of
using HexaPro in the development of next generation COVID-19 vaccines
because of its broad protection against SARS-CoV-2 variants.”
Overkill?
https://youtu.be/Ku42Iszh9KM
Now you were saying about ADE and flu vaccines?
>
> How come polio, and monkeypox are now becoming endemic? These diseases
> which existed for a long time already, but are only now becoming endemic, in the West.
>
Not sure you have the slightest fuck what you’re talking about, but polio
is coming from vaccine derived cases where older forms of attenuated virus
are used as oral vaccine, as this generates gut immunity, that mutates into
not so good stuff and winds up amongst antivax chowderheads who are
susceptible to getting really sick.
Monkeypox has become more of a thing because multiple contingent events
(not COVID vaccination). One irony is the post 9-11 panic stockpile of
smallpox vaccine went tits up due to shelf life and could have been sent to
Africa before that happened so non-Americans could benefit.
>
> That is not a coincedence, that is because they are now spread
> asymptomatically, because of people's immune system being pre-occupied
> with covid, and then having hyper active T-cell response instead of the
> antibodies doing the job.
>
What the fuck does that even mean? Do you even know? The immune system
multitasks. That’s why mine can deal with two vaccines at once dipshit.
What’s preoccupied even mean here? Oh wait flu vaccine, take a number and
wait, the immune system is romancing the Rona right now.
And lymphocytes have specificity. They each target only one antigen found
on one particular pathogen, though there can be some cross-reactivity.
Sooo…my lymphocytes geared toward COVID will not give one flying fuck about
monkeypox or polio.
And humoral and cellular immunity do stuff differently yes, but as antibody
titers contract plasma cells are still around and memory cells lie in wait.
T-cells surveil cell surfaces for indications of infection and tell cells
to go commit suicide when appropriate. It isn’t like they are filling in
for lazy B-cells getting drunk in the break room. That’s how adaptive
immunity is supposed to work. What the fuck is a hyper-reactive T cell
response. It’s just T cells doing T cell things.
>
> So the vaccinated become a cesspool for diseases.
>
The antivaxxers are a cesspit of disease. Plague rats all.
>
> You are just engaging in a ritualistic, doing your best psychosis,
> because you define choosing in terms of figuring out the best option. The
> only good feeling you are going to get from this, is that feeling that
> you did your best. Other than that you are going to be feeling sick, and
> feeling the final judgment on your soul.
>
I will be feeling like shit when the bivalent spike mRNA gets translated
and starts working its wonders. Final judgment? No. Just another jab.