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233 Primate Genomes
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RonO
Jun 4, 2023, 9:15:42 AM6/4/23
to talk-o...@moderators.isc.org
As part of the vertebrate genome project that is a subset of sequencing
the biodiversity of the Earth a group of researchers have developed a
data set of the genomes of 233 species of primates trying to gather 2 or
3 examples of each species. Science has published a series of articles
on the research (over 700 genomes in their data set).
https://www.science.org/content/article/hundreds-new-primate-genomes-offer-window-human-health-and-our-past
They aren't just using the data to refine the phylogeny of primates
including humans. They have an article on identifying the tolerated
variation in the human population and among other primates. You differ
from another relatively unrelated human by around 1 in 3,000 base-pairs
in terms of single nucleotide mutations (they are called polymorphisms
when segregating in the population). Most of these polymorphisms do not
do much of anything at all, but a few of them result in why you are
physically different from the unrelated individual that you are
comparing yourself to. The researchers claim that they can identify
tolerated variants by how often they occur in other primate genomes. If
natural selection has allowed the mutation to be fixed or occur at a
high frequency on other species it is more likely to be tolerated in the
human population. At the same time they identified a group of
polymorphisms that are not found in other primate species at a high
frequency, and they claim that these are the ones most likely to be
responsible for genetic disease in humans. Some of them were confirmed
in a couple other other papers in the primate genome series on
associating the human variation with phenotypes.
https://www.science.org/doi/10.1126/science.abn8197
Evolutionary analysis with medical significance.
Ron Okimoto
the biodiversity of the Earth a group of researchers have developed a
data set of the genomes of 233 species of primates trying to gather 2 or
3 examples of each species. Science has published a series of articles
on the research (over 700 genomes in their data set).
https://www.science.org/content/article/hundreds-new-primate-genomes-offer-window-human-health-and-our-past
They aren't just using the data to refine the phylogeny of primates
including humans. They have an article on identifying the tolerated
variation in the human population and among other primates. You differ
from another relatively unrelated human by around 1 in 3,000 base-pairs
in terms of single nucleotide mutations (they are called polymorphisms
when segregating in the population). Most of these polymorphisms do not
do much of anything at all, but a few of them result in why you are
physically different from the unrelated individual that you are
comparing yourself to. The researchers claim that they can identify
tolerated variants by how often they occur in other primate genomes. If
natural selection has allowed the mutation to be fixed or occur at a
high frequency on other species it is more likely to be tolerated in the
human population. At the same time they identified a group of
polymorphisms that are not found in other primate species at a high
frequency, and they claim that these are the ones most likely to be
responsible for genetic disease in humans. Some of them were confirmed
in a couple other other papers in the primate genome series on
associating the human variation with phenotypes.
https://www.science.org/doi/10.1126/science.abn8197
Evolutionary analysis with medical significance.
Ron Okimoto
Bob Casanova
Jun 4, 2023, 12:35:42 PM6/4/23
to talk-o...@moderators.isc.org
On Sun, 4 Jun 2023 08:11:15 -0500, the following appeared in
talk.origins, posted by RonO <roki...@cox.net>:
Interesting info; thanks! I'm unfamiliar with the meaning of
"tolerated variation" in this context. Does it mean
"variants not selected against"?
>
--
Bob C.
"The most exciting phrase to hear in science,
the one that heralds new discoveries, is not
'Eureka!' but 'That's funny...'"
- Isaac Asimov
talk.origins, posted by RonO <roki...@cox.net>:
"tolerated variation" in this context. Does it mean
"variants not selected against"?
>
--
Bob C.
"The most exciting phrase to hear in science,
the one that heralds new discoveries, is not
'Eureka!' but 'That's funny...'"
- Isaac Asimov
RonO
Jun 4, 2023, 2:20:42 PM6/4/23
to talk-o...@moderators.isc.org
are survivable and do not seem to be effectively selected against when
they occur, and can even be fixed in various species. It doesn't mean
that they have no effect on phenotype, they can have noticeable effects,
but these effects do not significantly affect the survivability of the
species.
Ron Okimoto
Bob Casanova
Jun 4, 2023, 5:40:42 PM6/4/23
to talk-o...@moderators.isc.org
On Sun, 4 Jun 2023 13:17:38 -0500, the following appeared in
OK; thanks. That's approximately what I thought.
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