FDA probes liver damage with diet pill, alli

[critterpatrol]

WASHINGTON – The Food and Drug Administration is investigating reports
of liver damage in patients taking alli, the only nonprescription
weight loss drug approved by the agency.
Regulators said Monday they have received more than 30 reports of
liver damage in patients taking alli and Xenical, the prescription
version of the drug. The reports, submitted between 1999 and October
2008, included 27 hospitalized patients, and six who suffered liver
failure.
Alli and Xenical are both marketed by British drugmaker
GlaxoSmithKline PLC, though Xenical is manufactured by Swiss firm
Roche.
The FDA says it has not established a direct relationship between the
weight loss treatments and liver injury, and advised patients to
continue using the drugs as directed.
"Consumers should consult their health care professional if they are
experiencing symptoms," the agency said on its Web site. Signs of
liver damage include fatigue, fever, nausea and vomiting.
The FDA said it's reviewing additional details about the suspected
cases of liver injury submitted by manufacturers.
Roche referred questions to GlaxoSmithKline.
A spokeswoman for GlaxoSmithKline said there is no evidence the
company's drug causes liver injury, noting that it primarily acts on
the intestinal tract. She said alli's safety has been studied in more
30,000 patients enrolled in 100 clinical studies.
"Liver changes can have many causes," said Debbie Bolding, in a
statement. "People who are overweight and obese are predisposed to
liver-related disorders."
The FDA first approved Xenical in 1999 and alli in 2007. The
prescription pill is twice as potent as alli, which can be bought over
the counter. Glaxo reported $123 million in sales for alli last year,
while Roche posted $472 million in revenue for Xenical.
In general, the FDA has started notifying the public earlier about
possible safety issues with drugs, after coming under fire for acting
too slowly on problems with blockbuster treatments like Merck's
painkiller Vioxx.
Shares of London-based Glaxo fell 59 cents Monday to close at $39.44.

http://news.yahoo.com/s/ap/20090824/ap_on_bi_ge/us_weight_loss_drug_fda

[cville1]

Well, this is one diet pill that I have never tried. I am too scared
of all the "other" side effects...especially if you eat the wrong
foods. After thinking of trying it once, I went on amazon.com to read
some of the comments. While a little bit funny to read, I definitely
wouldn't want it happening to me at work or anywhere else. So maybe
it works for Wynonna but this hillbilly is scared to try it for
sure. :)

[critterpatrol]

sorta reminds me of the song
great green globs of greasy grimey gopher guts.......

[lebanonfan]

Oooo! Around here it was 'Great BIG gobs of"....what you said. Somehow
interjecting 'green' there makes it worse!

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[cville1]

Exactly. :)

On Aug 25, 7:18 pm, critterpatrol <crzycatldy8...@yahoo.com> wrote:

[lebanonfan]

Cville? You all really did say "green"???

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[cville1]

Yep, with all the gr words it just seemed to fit,

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[critterpatrol]

mutilated monkey meat

what was the feet?

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[critterpatrol]

great green gobs of greasy grimey gopher guts
mutilated monkey meat
little dirty birdie feet
french fried eyeballs floating in a pool of blood
ooops, I forgot my spoon!!!!

I got another one, ya want hear it?????

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[cville1]

Yes. Does it have something to do with a granny and the condition of
her undergarments? I know you remember that one.

[critterpatrol]

no worse
want to hear it?
pretty crude

[critterpatrol]

ok
(it is a cheer)

rat shit bat shit dirty old twat
69 cock hairs tied in a knot
rah rah buzzard puke!!!!!!!!!

On Aug 26, 4:50 pm, cville1 <mdespa...@aol.com> wrote:

[lebanonfan]

I think ours was "punched out eyeballs dipped in kerosene"???

[cville1]

weelll, we never did that one but I'm from the sticks :)

[critterpatrol]

I have checked, ours was actually
french fried eyeballs dipped in kerosene

[critterpatrol]

It wasnt a whole school cheer!!!! sorta like just us gross kids

[cville1]

Yeah, I figured that. That would be some wild school cheer! :)

[critterpatrol]

but you need to SEE the motions that go along with it!!!!!!
hahahahahahahahahahahaa