Conventional fast 50mm primes tend to show quite obvious coma and astigmatism - aberrations which cause point light sources towards the edge of the frame to flare out. This can be problematic when shooting such things as star fields of city scapes at night. In the table below we're looking at how the Sigma fares in this respect, by shooting a bright white LED light placed at the extreme right hand corner of the frame using the Canon EOS 6D. We've deliberately over-exposed the light to show the maximum extent of the effect.
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Sigma Art series is THE reason I am using AF lenses again. Always struggled with Nikon pro prime offerings, always off, with in-camera fine tuning unable to resolve the issue (ok at infinity but off at closer distances or vice versa) unless all lenses and bodies sent to nikon for focus adjustment. Sigma and its dock resolve all that. Most importantly, it allows to fine tune the focus at different distances! The problem is not lack of control of the sigma lenses but loose tolerances on the bodies. They deserve my money for coming up with, what I consider, to be a breakthrough approach with excellent optics.
Non-muscle invasive bladder cancer (NMIBC) ranks among the most prevalent cancers in the US with nearly 80,000 individuals diagnosed annually. The majority of diagnoses occur at early stages where the cancer is contained in the epithelial lining of the bladder. Standard-of-care treatment for NMIBC involves surgical resection of the tumor and subsequent immunotherapy or chemotherapy. Addressing a scarcity of these agents, the University of Iowa Hospitals & Clinics pioneered a novel combination of gemcitabine and docetaxel for NMIBC treatment. However, this process necessitates patients to undergo an extended period of outpatient care, contributing to burden on healthcare professionals and a decrease in patient compliance. To streamline this procedure, enhance patient compliance, and alleviate the demand for a trained urologist, we developed an intravesical delivery system for docetaxel. The device consists of a drug-loaded, spiraled tube sealed with a carbohydrate cap and coated with a fluorinated polymer. This system allows administration via Foley catheter and provides a tunable delivery of docetaxel. Importantly, this innovation not only benefits patients with NMIBC, but also holds potential applications for treatment of urinary tract infections and other bladder diseases.
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