As far as I can tell, neutral morphemes in Mandarin only appear standalone or at the end of a multisyllable word. What is the significance of this? It means that in systems that employ tonal spelling the neutral syllable can be terminated with a silent character without ever interfering with the following syllable. For example
can be written as zhes with a trailing s and the trailing s will not be confused with the beginning of any following syllable, because what follows immediately after the s will always be a punctuation mark, a space, or something else, but never the characters of another syllable.