Book Of Disquiet Epub
Cheryll Witting
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Despite the advances in combinatorial chemistry, high throughput and virtual screening experiments, plethora of clinical studies disquiet due to lead and drug-likeness attritions. For mitigation, the knowledge of physicochemical properties are really useful for guiding and selection of compounds from libraries dictated by certain rule of thumbs. However, robust bio-technological and instrumental innovations have created exponential increase in novel compounds and databases which compelled rethinking of the evaluation procedures. Known descriptive molecular property filters proposed by Lipinski, Verber and Hann are not efficient enough to encompass long array of compounds. Moreover, these filters do not take into account the specificity of biological target. In this pursuit, we have tried to appraise eight molecular properties for two major classes of biological targets viz membrane proteins and ion channels binding ligands. These molecular properties were utilized to search for the specific attributes that can be identified as an intervening space for dictating the biological activity.
When the results of partial mental adaptations fall into such opposition that thought is driven in different directions and disquiet mounts to the point that we consciously and deliberately seek for a thread to lead us through this confusion, then a problem has arisen. A stable and customary area of experience to which thoughts have adapted themselves rarely gives rise to problems; at least it would require great mental sensitivity to differences if here too problems were to arise. However, if the area of experience becomes wider through certain circumstances and thoughts come into contact with hitherto unknown facts to which they are inadequately adapted and if the thoughts modified by novel adaptation react on the results of earlier adaptations, then a host of new problems develops, as the history of civilization in general and of science in particular shows. Problems arise when thought and fact, or thought and thought no longer agree. We have not the power to adduce hitherto unknown facts that depend in unknown ways on circumstances within our sphere; they meet us against our will, without or against our expectations, and although they lie outside the scope of our work or investigation, they arise from chance, that is through circumstances that may not be without rule but beyond our ken and influence.
N2 - Following the 1989 unified higher education reforms, the Australian academic research system was built upon the notion of depoliticisation (i.e., keeping the political character of decision at one remove from governance) to govern the contradiction between research credibility and governmental economic priorities. The article argues that the COVID-19 pandemic exacerbated the tension between independent research and governmental economic priorities. The pandemic, also, weakened university autonomy via the closure of the national border, reducing overseas student fees, a significant source of research funding. The article maintains that the conservative Morrison government used the opportunity to politicise research around commercialisation and national sovereignty. The argument being that the pandemic exposed Australia's research and development (R&D) dependence and with it the question of industrial sovereignty, prompting the government to couple academic research to industry policy. Secondly, the pandemic reinforced the conservative government's aim to concentrate research in selected commercial areas and to exert this priority on to the research funding agency, the Australian Research Council (ARC). Lastly, the article contends that the COVID pandemic, originating in Wuhan, intensified the Morrison government's geopolitical concerns over China, and this disquiet flowed into research policy, which problematised research collaboration with Chinese researchers.
AB - Following the 1989 unified higher education reforms, the Australian academic research system was built upon the notion of depoliticisation (i.e., keeping the political character of decision at one remove from governance) to govern the contradiction between research credibility and governmental economic priorities. The article argues that the COVID-19 pandemic exacerbated the tension between independent research and governmental economic priorities. The pandemic, also, weakened university autonomy via the closure of the national border, reducing overseas student fees, a significant source of research funding. The article maintains that the conservative Morrison government used the opportunity to politicise research around commercialisation and national sovereignty. The argument being that the pandemic exposed Australia's research and development (R&D) dependence and with it the question of industrial sovereignty, prompting the government to couple academic research to industry policy. Secondly, the pandemic reinforced the conservative government's aim to concentrate research in selected commercial areas and to exert this priority on to the research funding agency, the Australian Research Council (ARC). Lastly, the article contends that the COVID pandemic, originating in Wuhan, intensified the Morrison government's geopolitical concerns over China, and this disquiet flowed into research policy, which problematised research collaboration with Chinese researchers.
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