Episode 1.62
George
The benefits of long-term cyclosporin (CyA) therapy are not yet established and must be weighed against its toxicity. We studied cardiovascular risk factors in 25 patients who received a kidney transplant between 1985 and 1989 and in whom CyA was discontinued. The protocol for discontinuing CyA involved starting azathioprine (Aza) and then weaning CyA over 6 weeks without changing the prednisone dose. Parameters collected from the patients' charts 3 months before (pre) and 3 months after conversion (post) and at the most current follow-up (cur) included serum creatinine, cholesterol, blood pressure, and anti-hypertensive medication. The severity of the hypertension was graded, based on a hypertension index reflecting the nature and dose of the anti-hypertensive medication. Of the 25 patients in whom CyA was discontinued, 2 experienced a rejection episode during conversion and were switched back to CyA; 1 patient had a rejection episode after conversion but remained on Aza. Converted patients demonstrated improved renal function (1/Cr pre 0.69 +/- 0.20, post 0.84 +/- 0.23, P < 0.05), lower serum cholesterol levels (pre 6.8 +/- 1.0, post 5.8 +/- 1.2, P < 0.05), lower mean arterial pressure (pre 111 +/- 14, post 102 +/- 8, P < 0.05) and a lower hypertension index (pre 2.45 +/- 2.77, cur 1.62 +/- 1.70, P < 0.05). Although conversion may carry some risk of acute rejection, it improves graft function and the cardiovascular risk profile significantly.
Experimental hypercholesterolemia is characterized by increased endothelin-1 (ET-1) activity and is associated with an attenuated myocardial perfusion response and an inappropriate increase in coronary microvascular permeability during episodes of increased myocardial demand. This study was designed to determine the effect of chronic selective ET type A (ET(A)) receptor antagonism on coronary vascular response to simulated cardiac stress in experimental hypercholesterolemia. Twenty-one pigs were randomized to three groups: normal diet (N), high-cholesterol diet (HC), and HC diet plus ABT-627, a selective ET(A) receptor antagonist, (HC+ABT-627). After 12 weeks, cardiac electron beam computed tomography (EBCT) was performed before and during intravenous infusion of adenosine, and myocardial perfusion (ml/min per g) and coronary microvascular permeability index (arbitrary units) were calculated. Basal myocardial perfusion was similar in all groups (N: 0.91+/-0.10; HC: 0.95+/-0.08; HC+ABT-627: 1.03+/-0.09; P=0.64). Adenosine infusion led to a significant increase in myocardial perfusion in the N (1.32+/-0.15; P
Regional haze pollution can normally be divided into four stages comprising pre-accumulation, explosion, duration and dissipation, under which the physiochemical characteristics of aerosols were clearly distinct. In this study, the chemical compositions and mixing state of aerosols and their source apportionments during a regional haze pollution process in the North China Plain (NCP) were comparably discussed for the different haze evolution stages. Six main particle groups were identified, including carbon-rich particles (53.17%), K-rich particles (27.41%), heavy-metal particles (10.9%), sodium particles (5.61%), dust particles (1.62%) and ammonium particles (1.29%). Subsequently, the chemical components and size distributions of aerosols were found to vary during the different haze stages. Contrary to the OCEC, K-CN, Cu and Pb particles, the EC-nitrate, EC-secondary and Fe particle groups had increasing proportions with the development of the haze events. The fraction of K particles was higher during the pre-accumulation stage and descended rapidly during the subsequent haze stages. In contrast to the OCEC particles, the EC-nitrate and EC-secondary particles from 0.6 to 1.2 μm increased significantly with haze deterioration, implying the enhancement (decline) of aged (primary) carbonaceous particles during the haze episode. The source contributions of PM2.5 changed with the evolution of the haze events, with the largest percentage up to 52.23% from residual and industry emissions during the explosion stage. In contrast to industry and direct combustion emissions, the aging process and traffic emission contributed increasingly with the aggravation of the haze episodes, with higher fractions of 33.17% and 15.57%, respectively, throughout the duration stage.
New York [April 19, 2021] Unsellable Houses, starring Pacific Northwest real estate and home renovation power twins, Lyndsay Lamb and Leslie Davis, delivered the highest-rated episode for the series on Tuesday, April 13, at 9 p.m. ET/PT, garnering a .71 live plus three-day rating among P25-54 and a 1.0 L3 rating among W25-54. Attracting more than 4.5 million total viewers, the episode also earned a .73 among upscale P25-54, a 1.0 among upscale W25-54 and a 1.62 L3 rating with households. The episode ranked as a top three cable premiere in its Tuesday 9-10 p.m. timeslot in multiple key demos including P25-54, W25-54, households, P2+, upscale P25-54 and upscale W25-54.
Game notes vs. Purdue
Big Ten Tournament First Round
March 4, 2015
Sears Centre Arena, Hoffman Estates, Ill.
Team Notes
Wisconsin ends its season 9-10 overall and finished 11th in the Big Ten at 5-13.
The Badgers fall to 10-21 in 21 Big Ten Tournament. UW also falls to 1-5 against Purdue.
After shooting 59.3 percent (16-of-27) in the first half, Wisconsin shot just 33.3 percent (8-of-24) in the second to finish the game at 47.1 percent.
Wisconsin's shooting marked the 14th straight game it has shot 40 percent or better from the field.
The Badgers made just four 3-pointers, all in the first half, ending a streak of nine straight games with seven-or-more triples.
UW was outrebounded for the second-straight game as the Boilermakers finished with a 36-32 edge.
The Badgers also had only two scorers in double figures for the second straight game.
Wisconsin outblocked the Boilermakers 8-3, marking the seventh straight game with five-or-more blocks.
Individual Notes
Junior Dakota Whyte led the Badgers with 16 points, sharing game-high honors. The 5-8 guard was an impressive 7-of-10 from the field for 70 percent.
Junior Nicole Bauman added 14 points, her 12th straight double-digit scoring game and 23rd in 27 games this season. The 5-10 guard was a perfect 2-of-2 from 3-point range, upping her Big Ten-leading percentage from behind the arc to 48.8 percent (80-of-164) on the season.
Bauman also finished with a team-hm igh seven rebounds, marking the first time in her career as the leading Badger on the boards.
Senior Cassie Rochel set a Big Ten Tournament single-game record with seven blocks. She broke the previous mark of six blocks, set five times including in 2014 by Minnesota's Amanda Zahui B. Rochel also tied her career high with the total.
Rochel finishes her career with 178 blocks, which ranks second on the UW career record list. She also averaged 1.62 blocks per game over her four seasons, ranking third all time.
Three seniors played their final games in the Cardinal and White - AnnMarie Brown, Jacki Gulczynski and Cassie Rochel.
Background: Heat-related impacts may have greater public health implications as climate change continues. It is important to appropriately characterize the relationship between heatwave and health outcomes. However, it is unclear whether a case-crossover design can be effectively used to assess the event- or episode-related health effects. This study examined the association between exposure to heatwaves and mortality and emergency hospital admissions (EHAs) from non-external causes in Brisbane, Australia, using both case-crossover and time series analyses approaches. Methods: Poisson generalised additive model (GAM) and time-stratified case-crossover analyses were used to assess the short-term impact of heatwaves on mortality and EHAs. Heatwaves exhibited a significant impact on mortality and EHAs after adjusting for air pollution, day of the week, and season. Results: For time-stratified case-crossover analysis, odds ratios of mortality and EHAs during heatwaves were 1.62 (95% confidence interval (CI): 1.36-1.94) and 1.22 (95% CI: 1.14-1.30) at lag 1, respectively. Time series GAM models gave similar results. Relative risks of mortality and EHAs ranged from 1.72 (95% CI: 1.40-2.11) to 1.81 (95% CI: 1.56-2.10) and from 1.14 (95% CI: 1.06-1.23) to 1.28 (95% CI: 1.21-1.36) at lag 1, respectively. The risk estimates gradually attenuated after the lag of one day for both case-crossover and time series analyses. Conclusions: The risk estimates from both case-crossover and time series models were consistent and comparable. This finding may have implications for future research on the assessment of event- or episode-related (e.g., heatwave) health effects.
N2 - Background: Heat-related impacts may have greater public health implications as climate change continues. It is important to appropriately characterize the relationship between heatwave and health outcomes. However, it is unclear whether a case-crossover design can be effectively used to assess the event- or episode-related health effects. This study examined the association between exposure to heatwaves and mortality and emergency hospital admissions (EHAs) from non-external causes in Brisbane, Australia, using both case-crossover and time series analyses approaches. Methods: Poisson generalised additive model (GAM) and time-stratified case-crossover analyses were used to assess the short-term impact of heatwaves on mortality and EHAs. Heatwaves exhibited a significant impact on mortality and EHAs after adjusting for air pollution, day of the week, and season. Results: For time-stratified case-crossover analysis, odds ratios of mortality and EHAs during heatwaves were 1.62 (95% confidence interval (CI): 1.36-1.94) and 1.22 (95% CI: 1.14-1.30) at lag 1, respectively. Time series GAM models gave similar results. Relative risks of mortality and EHAs ranged from 1.72 (95% CI: 1.40-2.11) to 1.81 (95% CI: 1.56-2.10) and from 1.14 (95% CI: 1.06-1.23) to 1.28 (95% CI: 1.21-1.36) at lag 1, respectively. The risk estimates gradually attenuated after the lag of one day for both case-crossover and time series analyses. Conclusions: The risk estimates from both case-crossover and time series models were consistent and comparable. This finding may have implications for future research on the assessment of event- or episode-related (e.g., heatwave) health effects.
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