Time for some additional detail.
This is really two issues. #1, Send/Reply local CPU; #2, Send/Reply to another LAN CPU.
#1 seems less problematic so I'll document issue 1 later.
Here are more specifics for issue 2.
There are two receivers at this IP, klok is sc473-based, and klok3 is sc483-based.
The receiving CPU is running Tiger.
Sending script...
send "fubar" to program "eppc://
172.20.1.149/klok"
put the result into cd field 1
Receiving script...
on fubar
reply (the ticks)
end fubar
I used the "send" project using multiple operating systems, as well as using both 473 and 483.
Tiger client -- All 4 send options work as expected, including keychain authentication.
Lion client -- All 4 send options work but keychain recall does not work across multiple receivers.
Mountain Lion client -- 473 send (x2) results in "could not send session request"
Mountain Lion client -- 483 send (x2) results in error-600
ElCapitain -- same as Mountain Lion.
Sierra, HighSiera and Mojave -- same as Mountain Lion.
I skipped over some OS versions as it seems the significant lapse came with Mountain Lion and has not recovered since.
Hope this helps
Greg