Campus Stem Cell Lab meeting, Tuesday, April 16
Sue Gilbert
Next week, Tuesday, April 16, will be the next talk for this seminar. We will start at noon promptly. We will continue to provide sandwiches and chips starting at 11:40 am (water will be provided but if you want something else to drink please bring your own.) We will be back in The Wisconsin Institutes of Discovery (WID) for these. We will be meeting in the H.F. Deluca Forum in the Town Center on the first floor. Please ask at Information Desk if you are unsure where to go.
Date: Tuesday, April 16
Speaker: Nisha Iyer, SCRMC Trainee, Biomedical Engineering (Ashton lab)
Title: Regional Patterning of hPSC-Derived Posterior Central Nervous System Tissue
Abstract: In vitro modeling of the human central nervous system (CNS) is complicated by the diversity of constituent cell phenotypes, which arise from neural stem cells (NSCs) that are regionally patterned along both the rostrocaudal (R/C) and dorsoventral (D/V) axes during early development of the neural tube. Recapitulating this patterning with chemically defined, scalable protocols using human pluripotent stem cells (hPSCs) is necessary to optimally model the CNS in vitro and develop cell replacement strategies for regeneration. We have previously reported methods to regionally pattern hPSCs to neural stem cells (NSCs) expressing discrete R/C Hox profiles that span the hindbrain through spinal cord. Here, we develop methods to subsequently direct them to a ventral and dorsal fates by modulating Shh, Wnt/β-catenin and BMP signaling, thereby generating the first regional spectrum of human motor and somatosensory spinal populations. Having access to these populations will be a valuable resource for gaining insights into regional differences in spinal network development, modeling chronic pain or degenerative neuropathies, and conducting neurotoxicity and drug screening. Furthermore, we provide a clinically-relevant source of spinal populations for transplantation.
Reminder: If you are talking this Seminar Series for credit, please check in with Sue Gilbert at the back of the room.
Next talk: The next talk of the semester will be on Tuesday, April 23, with our nest speaker, Zhongwei Du, Xiang Li, and Su-chun Zhang, Neuroscience (Zhang lab), speaking on “Fast Generation of Functional Subtype Astrocytes from Human Pluripotent Stem Cells." This talk will be in the Wisconsin Institutes of Discovery (WID), H.F. Deluca Forum in the Town Center on the first floor, and will include sandwiches.
A list of the talks for the semester is found at:
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Phone: 608.263.2982
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