Campus Stem Cell Lab meeting, Tuesday, April 2
Sue Gilbert
Tomorrow, Tuesday, April 2, will be the next talk for this seminar. We will start at noon promptly. We will continue to provide sandwiches and chips starting at 11:40 am (water will be provided but if you want something else to drink please bring your own.) We will be back in The Wisconsin Institutes of Discovery (WID) for these. We will be meeting in the H.F. Deluca Forum in the Town Center on the first floor. Please ask at Information Desk if you are unsure where to go.
Date: Tuesday, April 2
Speaker: Mervin Yoder, Distinguished Professor Emeritus, Ped-Neonatal Medicine. Indiana University
Title: Identification of resident vascular endothelial stem cells in mouse and man
Abstract: Most organs and tissues are maintained lifelong by resident stem cells, however, it is unclear if stem cells replenish vascular endothelial cells throughout the systemic circulation. We report that the ATP cassette transporter Abcg2 labels murine resident vascular endothelial stem cells that display clonal proliferative potential and blood vessel forming ability to give rise to artery, vein, and capillary EC, in addition to displaying self-renewal activity in vivo. Transcriptome analysis reveals that Abcg2-expressing endothelial stem cells from different tissues express a common gene expression signature involved in angiogenesis and proliferation regulation in addition to distinct tissue-specific expression patterns. ABCG2 also serves as a marker that labels human resident vascular endothelial stem cells. These results are the first to establish that a single prospective marker identifies vascular endothelial stem cells in mouse and man and hold promise to provide new cell therapies for repair of damaged vessels in patients with endothelial dysfunction.
Reminder: If you are talking this Seminar Series for credit, please check in with Sue Gilbert at the back of the room.
Next talk: The next talk of the semester will be on Tuesday, April 9, with our nest speaker, Kaivalya Molugu, SCRMC Trainee, Biomedical Engineering, (Saha lab), speaking on “Tracking and predicting somatic cell reprogramming using nuclear characteristics." This talk will be in the Wisconsin Institutes of Discovery (WID), H.F. Deluca Forum in the Town Center on the first floor, and will include sandwiches.
A list of the talks for the semester is found at:
https://stemcells.wisc.edu/campus-lab-meeting-schedule/
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Stem Cell and Regenerative Medicine Center
8457 WIMR II
1111 Highland Avenue
Madison, WI 53705-2275
Phone: 608.263.2982
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