Reminder: Campus Stem Cell Seminar Series – Tuesday, October 1st | Special Guest Speaker
2 views
Skip to first unread message
JORDANA LENON
Sep 24, 2019, 12:58:59 PM9/24/19
to stem-cell-a...@googlegroups.com
Hello all,
As a reminder, the next Stem Cell Seminar series will be held next week Tuesday, October 1st – details below. This seminar will feature a special guest, Farshid Guilak, P.h.D., Co-director, Center of Regenerative Medicine, Washington University, St. Louis.
Time: 12:00 pm – NOON
Location: Wisconsin Institutes for Discovery (WID) – DeLuca Forum (300 S. Orchard St., Rm. 1256)
Speaker: Farshid Guilak, P.h.D., Co-director, Center of Regenerative Medicine, Washington University, St. Louis
Topic: Engineering Stem Cells with Synthetic Gene Circuits as Novel Therapeutic Delivery Systems
Abstract: Arthritis represents a painful and debilitating family of joint diseases that is characterized by progressive degeneration of the articular cartilage; however, there are currently few disease-modifying treatments available. Our lab has focused on tissue engineering approaches for resurfacing entire joints using adult stem cells and biomimetic 3D woven fiber scaffolds. Furthermore, we have used combinations of gene therapy and tissue engineering to develop tissue replacements that possess the capability for biologic drug delivery. In recent years, the advent of synthetic biology and gene-editing methods such as CRISPR-Cas9 has allowed for precise modifying gene networks that control cell behavior. We have applied a combination of principles from these fields to rewire cellular gene circuits in stem cells in a manner that allows us to create a unique, custom-designed cell type that can sense and respond to its biochemical environment in a preprogrammed way. These cells have been used to develop engineered tissue replacements with the ability for tunable, inducible, or feedback-controlled, auto-regulated biological responses. In addition to recapitulating the biochemical and biomechanical properties of the tissue, these “smart” constructs can provide controlled drug delivery and immunomodulatory responses to the joint as therapies for osteoarthritis or rheumatoid arthritis.
Reminder: If you are taking this Seminar Series for credit, please check in with Hollie Thompson at the back of the room.
Next Seminar: On Tuesday, October 8th, Darcie Moore, Assistant Professor, Neuroscience, will be speaking on “The Regulation of Proteostasis in Mammalian Neural Stem Cells” This talk will be in the UW Biotechnology Center Auditorium (425 Henry Mall, Rm. 1111 - map).
A list of the talks for the semester is found at:
https://stemcells.wisc.edu/campus-lab-meeting-schedule/
Thank you,
Hollie Thompson (she, her, hers)
-
Administrator
Stem Cell and Regenerative Medicine Center
1111 Highland Avenue, STE 8457
p. 608-263-2982
e. hjth...@medicine.wisc.edu
As a reminder, the next Stem Cell Seminar series will be held next week Tuesday, October 1st – details below. This seminar will feature a special guest, Farshid Guilak, P.h.D., Co-director, Center of Regenerative Medicine, Washington University, St. Louis.
Time: 12:00 pm – NOON
Location: Wisconsin Institutes for Discovery (WID) – DeLuca Forum (300 S. Orchard St., Rm. 1256)
Speaker: Farshid Guilak, P.h.D., Co-director, Center of Regenerative Medicine, Washington University, St. Louis
Topic: Engineering Stem Cells with Synthetic Gene Circuits as Novel Therapeutic Delivery Systems
Abstract: Arthritis represents a painful and debilitating family of joint diseases that is characterized by progressive degeneration of the articular cartilage; however, there are currently few disease-modifying treatments available. Our lab has focused on tissue engineering approaches for resurfacing entire joints using adult stem cells and biomimetic 3D woven fiber scaffolds. Furthermore, we have used combinations of gene therapy and tissue engineering to develop tissue replacements that possess the capability for biologic drug delivery. In recent years, the advent of synthetic biology and gene-editing methods such as CRISPR-Cas9 has allowed for precise modifying gene networks that control cell behavior. We have applied a combination of principles from these fields to rewire cellular gene circuits in stem cells in a manner that allows us to create a unique, custom-designed cell type that can sense and respond to its biochemical environment in a preprogrammed way. These cells have been used to develop engineered tissue replacements with the ability for tunable, inducible, or feedback-controlled, auto-regulated biological responses. In addition to recapitulating the biochemical and biomechanical properties of the tissue, these “smart” constructs can provide controlled drug delivery and immunomodulatory responses to the joint as therapies for osteoarthritis or rheumatoid arthritis.
Reminder: If you are taking this Seminar Series for credit, please check in with Hollie Thompson at the back of the room.
Next Seminar: On Tuesday, October 8th, Darcie Moore, Assistant Professor, Neuroscience, will be speaking on “The Regulation of Proteostasis in Mammalian Neural Stem Cells” This talk will be in the UW Biotechnology Center Auditorium (425 Henry Mall, Rm. 1111 - map).
A list of the talks for the semester is found at:
https://stemcells.wisc.edu/campus-lab-meeting-schedule/
Thank you,
Hollie Thompson (she, her, hers)
-
Administrator
Stem Cell and Regenerative Medicine Center
1111 Highland Avenue, STE 8457
p. 608-263-2982
e. hjth...@medicine.wisc.edu
Reply all
Reply to author
Forward
0 new messages