Hi Antonio,
according to documentation you should be able to use PROJ strings:
ST_Transform( geom Geometry , newSRID Integer , area_of_use Geometry , proj_string_from Text , proj_string_to Text ) : Geometry
Here is one example that uses NTv2 file:
FROM:
+proj=tmerc
+lat_0=0 +lon_0=16.5 +k=0.9999 +x_0=500000 +y_0=0 +ellps=GRS80 +units=m
+towgs84=0,0,0,0,0,0,0
TO
+proj=tmerc +lat_0=0 +lon_0=15 +k=0.9999
+x_0=5500000 +y_0=0 +ellps=bessel +nadgrids=./HRNTv2.gsb +units=m