The last Image Capture (ICA) scanner driver that Brother posted for this device is in Oct 2020. They could not have tested this will macOS Big Sur (11.0 or later) as the release date was in November. So, if you have installed the version3.3.0 ICA driver and it doesn't work as expected, either Brother will eventually update that ICA driver or you will need to consider trialing and/or purchasing VueScan Professional which drives the ADS-2100e without any Brother software or drivers necessary.
If you're using Windows and you've installed a Brother driver, VueScan's built-in drivers won't conflict with this. If you haven't installed a Windows driver for this scanner, VueScan will automatically install a driver.
df19127ead