I've written some Python bindings for Sophia 2.1, they can be found on GitHub:
https://github.com/coleifer/sophy
I'd appreciate any feedback from the community on the APIs or ideas for improvement. The library currently supports most APIs (env + multiple dbs, string/u32/u64/multi-part indexes, point-in-time views, transactions, cursors), but does not yet have support for upsert or async. Thanks!