Xdk 5849

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Dominik Ransom

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Aug 5, 2024, 4:44:14 AM8/5/24

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The ecdysone agonist RH 5849 (1,2-dibenzoyl-1-tert-butylhydrazine) causes the premature initiation of molting at all stages of larval development of the tobacco hornworm, Manduca sexta. This phenomenon occurs without an increase in the endogenous ecdysone (20-hydroxyecdysone) titers. RH 5849 likewise provokes the initiation of molting in larval abdomens in the absence of a source of endogenous hormone. Although substantially less active than 20-hydroxyecdysone in vitro, RH 5849 was 30 to >670 times as active as the authentic molting hormone in bioassays with isolated larval abdomens or intact hornworms. This reversal in potency can be attributed to the superior transport properties and metabolic stability of RH 5849 relative to 20-hydroxyecdysone. Thus RH 5849 and its analogs are relatively persistent ecdysone agonists that halt feeding in larval lepidoptera by forcing an ultimately lethal, developmentally premature molt.

X-21-5849 is a colorless to light yellow liquid that is transparent to slightly hazy. This product features a long lasting film for both rinsed and leave-on products. It is used in makeup, hair care, and skin care applications. X-21-5849 comes ready to use packaged in either a 18kg can or a 180kg drum.

In 1953, Shin-Etsu Chemical became the first firm in Japan to venture into the silicones business. Since the company has created a diverse line of products designed to exploit the unique and useful properties of silicones in different fields.

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