Porphyria and the descendants (?) of Henry VIII

[Leo van de Pas]

I am trying to learn more about how porphyria is passed on. Apparently when a person has it, each of his/her children has a 50 percent chance of getting it.

It seems known that Mary, Queen of Scots, may have been a sufferer and so was her son James VI-I, then there is a long gap and "porphyria (?)" does not emerge until George III.
How does this "inheriting" work? Is it a combination of inheriting the ability which then perhaps is sparked off by food, medicine, environmental triggers?

Mary, Queen of Scots, may have inherited the disease through her grandmother, Margaret Tudor. Margaret's eldest brother, Arthur, Prince of Wales, apparently also had some of the symptoms.

This brings me to Henry VIII. Anthony Holden came with some compelling details in regards to the paternity of the children of Mary Boleyn. If they are the children of Henry VIII, there should be a good chance that porphyria is passed on amongst their descendants as well.

Does anyone know about "madness" amongst the Cary descendants?

Many thanks.
Leo van de Pas

[Sutliff]

Leo,

Although it too is unproved, I believe the case for Sir John Perrot being a
son of Henry VIII is stronger than that of the Cary children. The likeness
of John to Henry VIII was considered remarkable. IIRC Perrot is the only
individual named (other than Elizabeth herself) in her coronation procession
or something of the like.

I suppose it is all in what you want it to be, but Holden's article left me
with too many questions and uncertain conclusions as to accept his
evaluation as certain. I know the descendants of the Carys and Perrot want
the Henry VIII link, but the evidence seems insufficient to me.

Hap

"Leo van de Pas" <leov...@bigpond.com> wrote in message
news:01ad01c38dea$7a8b0260$3f9afea9@old...

[Francois Guyard]

To this question, you can have a look at
http://www.people.virginia.edu/~rjh9u/scot.html

Regards,

François Guyard

[Don Stone]

Leo van de Pas wrote:
> This brings me to Henry VIII. Anthony Holden came with some compelling details in regards to the paternity of the children of Mary Boleyn. If they are the children of Henry VIII, there should be a good chance that porphyria is passed on amongst their descendants as well.

Marshall Kirk emailed me recently, noting that the author of the article "Mary
Boleyn's Carey children -- offspring of King Henry VIII?" in the March 1997
issue of the Genealogists' Magazine is Anthony _Hoskins_.

-- Don

[Betty Harris]

Read this for answers to porphoria
" George III and the mad-business" / Ida Macalpine & Richard Hunter. *

by Macalpine, Ida.
Pantheon, [1970, c1969]

Call#: 616.399 Mac

> Does anyone know about "madness" amongst the Cary descendants?
>
> Many thanks.
> Leo van de Pas
>

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[David Suiter]

George Carey 2nd Baron Hunsdon died 9 Sep 1603 from venereal disease and
mercury poisoning. Did he have porphyria rather than this diagnosis, he
would have psychosis and skin problems, mercury would not have helped his
sanity or his alleged VD.

David Suiter

"Don Stone" <don....@verizon.net> wrote in message
news:gOkhb.32927$kD3....@nwrdny03.gnilink.net...

[Robert S Baxter]

Leo,

Porphyria is a group of disorders caused by different enzymes in the
biosynthesis of heme, an iron-containing piqment which is part of the
hemoglobin molecules. The most common varieties of porphyria are what is
called autosomal dominant, which means that a person need only have one
abnormal gene to have the disease. An affected person has an affected
parent. If an affected person and an unaffect person marry they will have
half affected and non-affected children on average. The unaffected children
of an affected parents will also have unaffected children. The disease
affects males and females equally. The risk of occurrence among children of
an affected person is 50%.

The expression of the gene in the appearance of a trait or disease is not
alway complete because it is affect by the enviroment and by other genes
which may alter the appearence of the trait in an affected person. In this
case, sometimes the expression of the gene is so low that the clinical
abnormality cannot be detected, yet the defective gene may be passed on to a
child who may be fully affected.

In the case of recessive forms of porphyria, which are rarer, if normal
parents have an affected child, the parents are both carriers. And on
average 1/4 of the children will be affected, one quarter will be normal,
and 50% will be carriers. Consanguinity is imporatant in autosomal recessive
diseases. Carriers appear normal.

In acute intermittent porphyria, stomach pain is common and psychiatric
symptoms can occur. The urine may be reddish or brown. In cutaneous
porphyria, which most common, blistered skin on sun-exposed parts of the
body is common.

Regards,

Bob
.

[LadyL...@yahoo.com]

I have Porphyria. My genealogy goes back to Frederick The Great thru
his son Prince Rupert of the Rhine(Bavaria) on my father's side and
back thru the royal Spencers and Du Trieux on my mother's side.
It is suspected I have the rarer form of Harderoporphyria that takes
two recessive genes, one from each parent. However, it cannot be proven
unless I can get to France for DNA testing as it is not being done
anywhere else at the moment and biological material cannot be sent from
the US to France right now without complications that would compromise
the sample.
Ravyn, Lady Heresy

[David Rorer]

Frederic the Great had no children, legimate or otherwise, so how could your
genealogy go to him through Prince Rupert of the Rhine?
<LadyL...@yahoo.com> wrote in message
news:1103038469.9...@c13g2000cwb.googlegroups.com...

[Leo van de Pas]

Dear David,
Read the name signed at the bottom of that message and you should realise
you have had your leg pulled. Raving Heresy alright. Rubbish but I think it
was meant to be.
Best wishes
Leo van de Pas