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The synthesis of LSD and psilocybin in the early to mid-20th century sparked not only a new counterculture in the United States but also a new interest in brain science, specifically the role of neurotransmitters.

Despite these discoveries, research on psychedelics went dormant for decades due to anti-drug sentiment. A recent renaissance in psychedelic research seeks to understand how these drugs might be leveraged as tools in treating mental illness.

While this work has focused largely on mathematical modeling and resting-state neuroimaging, that is now shifting: Cognitive neuroscientists are bringing new rigor to the field, using behavioral and clinical studies to investigate the cognitive effects of psychedelic drugs.

“Despite psychedelics having some of the most interesting subjective effects of any psychoactive drug, they’re generally being shown to impair cognition like most psychoactive drugs,” says Manoj Doss of Johns Hopkins University, who is chairing a symposium on psychedelics and cognition at the Cognitive Neuroscience Society (CNS) annual meeting today in San Francisco.

“One reason for this is that cognitive neuroscientists have been less involved with this work, so when the impact of psychedelics on cognition is measured, the tasks tend to be relatively simple and outdated.”

The landscape for these studies is rapidly changing, however, with a wealth of new research, looking at everything from how psychedelics can aid in understanding the malleability of memory to exactly how psilocybin can increase the spontaneous creative process.

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