Re: Pretty Son Nu...
Lora Ceasor
To me, Grace Jones is the Queen/King of androgyny, she tiptoes the line between masculine and feminine so perfectly and either way she is absolutely striking to look at. Like Ms Jones, Nu is androgynous, it is neither wholly masculine, feminine or unisex, it creates its own rules about gender and takes facets from both sexes.
Nu (this review refers to the Eau de Parfum) was released in 2001 and was created by Jacques Cavallier under the art direction of Tom Ford. I mentioned in my review of Gucci Rush that everything Tom Ford did whilst at Gucci, YSL and Lauder was pretty much epic, and I stand by that. With Nu, he and Jacques Cavallier created something unique and way ahead of its time.
The pepper becomes stronger and spicier in the heart, and as the coolness of the opening fades, the incense comes along to warm things up. What makes Nu genius is the pairing of the warm incense and spices with a sweet, slightly sharp white floral note. I would swear that there is also a dab or two of iris within the heart, there is a soft powderiness with a mere hint of that earthy routines that is the signature of iris.
Nu has excellent longevity and projection, it lasts for over 24 hours on the skin and after each note finally gives up the ghost and leaves the skin you are left with a warm, slightly sour woody/vanilla hue that feels like a second skin.
Thanks for reviewing this beautiful classic. You have reminded me to wear it more often. I have a bottle, but because of the hot weather, I have not worn it for months. There is now a slight chill in the air, and it is time to rediscover Nu!
Hello, I join you in loving NU. I bought it in 2004 when it was still fairly new on the market and fell madly in love with it. The bath products, especially the black soap and the creamy body lotion are spectacular. I did have to learn to be careful in applying the fragrance because it is so strong that several family members objected. I bought several bottles since I had guessed that it might not be around long. Was that ever a good move!
I am working on a large-ish RNA-protein complex with one protein bound with some conformational heterogeneity.
3DVA followed by clustering has been pretty awesome at yielding a discrete conformation.
The cluster structure is binned (256 from 512), so I scale back up to full size particles using NU-refinement (which seemed to work better than homogeneous refinement).
As I suspect the static part of the complex dominates refinement, I tried to follow the NU-refinement with a local refinement, masking around the protein of interest (with no particle subtraction for now).
However, this led to an overall loss of resolution (as I understand things, that would be likely, as the resolution of the NU is at least partially influenced by the static part), and, more importantly, the map looks worse (see attached).
the input for the NU are the particles and volume from the cluster that looks good, then I pull the blobs from the unbinned original refinement (the one that was used for binning).
Is there a more correct way of unbinning?
I have tried using the gaussian prior setting, and I have reduced the SD two 3 and 2 , but I am still losing definition. I am trying to incorporate particle subtraction now, maybe that will help combined with the rotation/shift constraints.
The only other thing that comes to mind is that you may have some compositional heterogeneity (presence/absence of the subunit of interest) in addition to conformational heterogeneity. In this case you might get some benefit from isolating a higher occupancy set of particles by performing masked classification without alignment in relion or similar.
Also what initial lowpass are you using in local refinement? For small volumes, going just a bit worse than the global refinement can be beneficial (e.g. 8 filter for somewhere that previously had an estimated local resolution of 4.5)
At this point, local refinement around my protein of interest is causing the problems I mentioned (as shown in the figure on the right side - all density of my protein of interest just looks worse), and resolution is stuck at 5.8 .
Hi Luca - you may find that a masked classification without alignments does a better job of separating your apo from your holo classes (perhaps as a second step after heterogeneous refinement and an initial NU-refine step)
Resolution is 5.8 , but it is pretty clean (before it supposedly was 5.6, but not really interpretable) . I can trace the whole backbone of the protein-of-interest, and I see blobs for larger residues that help adjusting the crystallographic model I am using.
We love vintage guitars for very much the same reasons we love listening to vinyl. While they might not play as great as a shiny new high-end, precision built custom axe, their magic lies in their flaws. Every ding and scrape tells a story, every little bit of player wear and lacquer checking lends a feeling and leads to inspiration. Same goes for records.... a little bit of noise and static pops add ambiance, allowing the listener to get lost in the music while mesmerized by the rotating platter.... its not so much about fidelity but rather warmth and texture to create a mood. We set out to combine our love for guitars with our love for records and the result is the NU-33.
Named after the Greek letter symbolizing spatial frequency and the RPMs of a turntable, the NU-33 is a lo-fi Vinyl modulator like no other. Designed to capture the vibe of some our favorite records such as a particularly worn out copy of Black Sabbath's Master of Reality and an original pressing of Led Zeppelin I with just the perfect amount of static, the NU-33 serves up chorus and vibrato mixed with tastefully engineered hiss, crackle and pops to give your riffs just the right touch of vintage flair. The controls allow you to choose how much or how little flutter to add to your tone, color it with 2 additional filter modes, shape it with 3 different waveforms and dial in the mix with an analog blend; you can easily make this pedal sound as pretty and lush or as dark and sombre as you please.
Once we were finally happy with the way it sounded, it was time to pepper it with all the fun bits! Crammed in this little box is a manual mode to create a doubler ranging from 15ms to 50ms, an internally assignable expression pedal/CV input, multi-function foot switches for tap tempo and speed ramping, top jacks, relay based true bypass switching and a hold-to-skip function with 3 selectable speed presets to create a unique sonic stutter.
All SolidGoldFX products purchased through the solidgoldfx.com website or our authorized dealers come with a three-year warranty against failure resulting from defective parts and/or faulty workmanship. Cosmetic flaws or issues related to wear and tear are not covered.
The warranty applies only to the original owner of the product and is not transferable. Warranty coverage terminates three years after the owner receives the product. While a product is under warranty, the product will be repaired free of charge. The owner of the product will be responsible for both shipping to and from SolidGoldFX Pedals. Warranty coverage will be automatically canceled should the product be tampered with, modified, abused, damaged through misuse, repaired by an unauthorized third party, or damaged through failure to follow the operating instructions.
USE OF AN IMPROPER POWER SUPPLY WILL VOID THE WARRANTY
Now I have finally landed on a concept that works very well for me and my excursions. I use my stuff every week, often several times a week for various things, forest trips, etc. and feel that most of it works pretty much as I intended it to! The items are durable, adjustable and just the right size.
Most people who are looking to get a backpack for bushcraft can expect to pay anywhere from SEK 1,000 (ca 100 USD) and up for a new backpack. More likely around SEK 2,000 (ca 200 USD). A backpack from military surplus, on the other hand, you can get a tenth of that price. A used rucksack with many miles ahead goes for SEK 300 and 500 (ca 30 to 50 USD). If you are not satisfied with your choice, you can often sell it for exactly the same amount or more. Meanwhile a nice new outdoor backpack quickly loses market value.
Before this, I used several different backpacks, depending on what was to be packed that particular day. It was of course extremely frustrating not being able to have a ready-made solution that was ready and just thrown into the car when it was time for a day in the woods.
The medium version of these is the one that has been used the most for shorter trips. It swallows what you need for the day regardless of whether you have to carry things for yourself only, or the rest of the family as well. If you need extra space, it is easy to attach certain things to the outside of the backpack and install side pockets. You quickly reach around 60 liter packing capacity this way!
Visual Studio Code (VS Code) is a popular and powerful code editor that is widely used by developers around the world. One of the reasons for its popularity is its customisable interface, which allows users to change the appearance of the editor with various themes. With so many options to choose from, it can be overwhelming to find the perfect theme that not only looks great but also helps you stay focused while coding.
In this article, we will introduce you to 19 beautiful VS Code themes that you can use to enhance your coding experience. From vibrant and colourful to minimalistic and sleek, these themes are sure to make your code editor stand out while helping you stay productive. So, let's dive in and explore these amazing themes!
The colour choice has been made brilliantly which makes this theme dark but not too dark. If you want something between a light and dark theme, this is a perfect choice. The Nord theme has been installed more than 715,000 times to date in VS Code.
Ayu is similar to a few others on this list in terms of the colour scheme. The defining feature, and what sets it apart for me is that it's got a black background instead of charcoal. For some reason this makes all the code more visible and distinct. Ayu is one of the most popular themes on VS Code marketplace with over 1.8 million installs.
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