Talk 25 Jan 2019: Cédric ALLIER (CEA-Leti Grenoble) on Deep learning technologies for living cells microscopy

[Jakob Verbeek]

Talk 25 Jan 2019, 11am, INRIA Grenoble (Montbonnot), F107

Deep learning technologies for living cells microscopy

Dr. Cédric ALLIER (CEA-Leti Grenoble)

In the present talk, I will discuss the recent development of deep 

learning technologies applied to microscopy techniques of living cells 

(2D and 3D cell culture, organoids, tissue etc.). A large number of 

publications appear recently discussing the advantages of CNN applied to 

microscopy, to e.g. improve the image quality, reduce the acquisition 

time, reduce the number of frame (super-resolution, 3D tomographic 

reconstruction), to perform cell segmentation and  classification, etc.

In particular I will discuss the combination of deep learning and 

lens-free microscopy, a technique that we are developing since 2009 at 

CEA-Leti. This technique relies already heavily on computation, since in 

this setup the optics are replaced by holographic reconstruction 

algorithms.  In comparison with existing techniques, this microscope 

combines several advantages: it is very small, cheap, yet it provides an 

extremely large field of view (30 mm2) showing at a glance N>20.000 

cells. Recently, we showed, for the first time, 3D+time acquisitions of 

3D cell culture with a lens-free microscope. We obtained time-lapse 

views of 3D culture of prostate epithelial cells showing complex 

cellular self-organizations that occurred through migration of single 

cells, displacement of large clusters, and merging and interconnection 

over long distances (>1 mm). Today, our team is pushing further the 

computational aspect of holographic microscopy by integrating 

deep-learning technologies. Our aim is to develop algorithms that will 

help the biologists and clinicians to perform automatic acquisitions and 

analysis of cultured cells, cultured tumors, and tissue.

[Jakob Verbeek]

--

Jakob Verbeek
+33.6.28.06.31.36

[Jakob Verbeek]

Reminder of a talk tomorrow 11am @ INRIA Montbonnot

On Sat, Dec 15, 2018 at 10:35 PM Jakob Verbeek <j.j.v...@gmail.com> wrote:

--

Jakob Verbeek
+33.6.28.06.31.36