I don't know of anyone using Skia built for Native Client. There was a time when Native Client builds were part of our continuous integration, but I don't recall anyone ever actually seeing if they ran. I certainly don't think it'd be any faster than the version of Skia you find in Chrome, and likely much slower due to a lack of CPU-specific optimizations and access to the GPU backend.
Last I heard Native Client in Chrome is deprecated and slated for removal in a few months:
https://developer.chrome.com/native-client/migration. You might want to keep that in mind as you look into investing in Native Client. I suspect the same speed caveats apply to any replacement like WebAssembly.