Biomedical Optics for Cell and Tissue Diagnostics - 多院系Nanophotonics学术交流

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Biomedical Optics for Cell and Tissue Diagnostics - 多院系Nanophotonics学术交流

报告题目: Biomedical Optics for Cell and Tissue Diagnostics

时间: 2011年1月7日(星期五)下午4点

地点：电信楼群3号楼200号会议室

报告人:
Mary‐Ann Mycek, Ph.D.
Associate Professor, Dept. of Biomedical Engineering
Faculty Member, Applied Physics Program
Core Member, Comprehensive Cancer Center
University of Michigan, USA

Abstract:
Our research in Biomedical Optics develops tools to probe and quantify living biological systems, with a goal of impacting clinical care by creating non‐ and minimally‐invasive biomedical optical diagnostic technologies. The translational "bench to bedside" research strategy we employ involves experimental studies on living cells, tissue‐engineered constructs, and primary human tissues, as well as computational studies with photon‐tissue interaction models. Several applications of optical molecular imaging via ultrafast fluorescence lifetime microscopy for quantitative, live cell imaging will be described, including studies of metabolic function and intracellular oxygenation, FRET studies of oncogene association, and microfluidic bioreactor characterization for continuous cell culture. Initial studies employing metabolic redox sensing via endogenous fluorescence will be described for non‐invasive, quantitative viability assessment in 3‐D engineered human tissue constructs. Optical studies of human pancreatic tissues using prototype clinical instrumentation will be discussed, including quantitative photon‐tissue interaction models and tissue classification algorithms developed to detect pancreatic cancer using multi‐modal optical spectroscopy.

Biography:
Mary‐Ann Mycek, Ph.D., is an Associate Professor in the Biomedical Engineering (BME) Department at the University of Michigan. She received her Ph.D. in Physics from U.C. Berkeley, where she specialized in condensed matter physics and optical spectroscopy, before pursuing postdoctoral training in laser medicine at Massachusetts General Hospital and Harvard Medical School. As an Assistant Professor of Physics at Dartmouth, she established an experimental and computational research group in biomedical optics, a multidisciplinary field incorporating elements of the physical and life sciences, engineering, and medicine. At the University of Michigan, she joined the College of Engineering as an Associate Professor of BME and established the Biomedical Optics Laser Laboratory. Her translational research program includes basic (pre‐clinical), applied (clinical), and computational research toward quantitative, noninvasive, optical sensing and imaging in cells and tissues. Recently, she served as an Associate Chair for the BME Department and in this capacity was Director of the U‐M Graduate Program in BME.

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