I have updated my local dev back to full trust and the problem is still occurring. There are no exceptions being generated/logged either.
at lambda_method(Closure , IDictionary`2 )
at Simple.Data.ConcreteTypeCreator.Create(IDictionary`2 source) in D:\\Projects\\3rd Party\\Simple.Data\\Simple.Data\\ConcreteTypeCreator.cs:line 35
at Simple.Data.ConcreteTypeCreator.TryCreate(IDictionary`2 source, Object& result) in D:\\Projects\\3rd Party\\Simple.Data\\Simple.Data\\ConcreteTypeCreator.cs:line 42
I assume that this is a security related exception, but I am not sure.