SIDERITE update log

[Ruolin He]

In this conversation, SIDERITE team will record the update of SIDERITE database.

Announce new siderophores will be added into database in advance.

[Ruolin He]

Recently (may April or May in 2024), we will update SIDERITE to cover new siderophores.

As of 2024-3-13, there are 52 new siderophores with unique structures after the first version of SIDERITE.

Here is the list of new siderophore names:

Aeruginaldehyde
Aerugine
Aeruginoic acid
Aeruginol
Avenic acid B
C12 acylated desferrioxamine+200+200+30
C12 acylated desferrioxamine+200+30
C12 acylated desferrioxamine+30
Caribactin A
Caribactin B
Caribactin C
Caribactin D
Caribactin E
Caribactin F
Chlorodactyloferrin
Dactyloferrin
Dihydroaeruginoic acid
Fulvivirgamide A2
Fulvivirgamide B2
Fulvivirgamide B3
Fulvivirgamide B4
Methyl 2-(2-hydroxyphenyl)-4,5-dihydrooxazole-4-carboxylate
Methyl thiazostatin B
Myxochelin B-succinate
N,N′,N′-tris(S-2,3-dihydroxybenzoyl)-O-seryl-O-seryl methoxy serinate
N,N′-bis(S-2,3-dihydroxybenzoyl)-O-seryl methoxy serinate
Nobachelin A
Nobachelin B
Nobachelin C
Pacifibactin-Ser
Pulicatin A
Pulicatin B
Pulicatin C
Pulicatin D
Pulicatin E
Pulicatin F
Pulicatin G
Pulicatin H
Pulicatin I
Pulicatin J
Pyonitrin A
Pyonitrin B
Pyonitrin C
Pyonitrin D
Pyoverdine P482
Serratiochelin D
Spoxazomicin E
Streptochelin A
Thermochelin
Thiazostatin C
Tistrellabactin A
Tistrellabactin B

[Ruolin He]

SIDERITE update log in 20240531Number change

The number of SIDERITE records = 872 (last time) + 77 (new records) - 4 (4 duplication: NBRI16716A, Amonabactin T789, Amonabactin P750, Pacifibactin-Gly. See "Correct and update records" for more details.) = 945

The number of unique siderophore structures: 649 + 62 (new) - 4 ( 4 duplication: SID00046, SID00047, SID00068, SID00170) = 707

The number of Siderophore clusters: 25 - 1 (Cluster 5) + 2 (Cluster 5 and Cluster 26) = 26

Archive files

SIDERITE_records_20240531.xlsx
contains 945 siderophore records

SIDERITE_unique_structures_20240531.xlsx
contains 707 unique siderophore structures

The same siderophore structures can be found in different species, leading to multiple records. Therefore, the number of siderophore records can exceed the number of unique siderophore structures.

They can be downloaded in zenodo: https://zenodo.org/doi/10.5281/zenodo.11441109

Correct and update records

1. Corrected the structure of Malleobactin A (SID00236) in Burkholderia pseudomallei
2. Corrected name of the second record of Pacifibactin-Gly in Alcanivorax pacificus. It should be Pacifibactin-Ser, rather than Pacifibactin-Gly.
3. Deleted duplicate NBRI16716A of Perisporiopsis melioloides Mer-f16716.
4. Corrected name of Linear trichrisobactin. It should be Linear trichrysobactin.
5. Corrected name of Aeruginic acid. It should be Aeruginoic acid.
6. Merged Amonabactin T789 (SID00204) into Amonabactin T (SID00203). They are same in the structure.
7. Merged Amonabactin P750 (SID00205) into Amonabactin P (SID00206). They are same in the structure.
8. Merged Linear trichrysobactin (SID00217) into Frederiksenibactin (SID00218). They are same in the structure.
9. Merged Legiobactin (SID00126) into Rhizoferrin (SID00127). They are same in the structure.
10. Deleted SID00204, SID00205, SID00217, SID00126 due to mergence.
11. Exchange the main name and other name for SID00046, SID00047, SID00068, SID00170.
    Now main name (the other name) is as follows:
    Gentisic acid(2,5-dihydroxybenzoic acid)
    Protocatechuic acid(3,4-dihydroxybenzoic acid)
    Salicylic acid(2-hydroxybenzoic acid)
    Itoic acid(2,3-dihydroxybenzoylglycine)
12. Update Phylum due to NCBI Taxonomy update: Proteobacteria is replaced by Pseudomonadota. Actinobacteria is replaced by Actinomycetota. Bacteroidetes is replaced by Bacteroidota.
13. Update Class due to NCBI Taxonomy update: Actinomycetia is replaced by Actinomycetes.
14. Update Order due to NCBI Taxonomy update: Streptomycetales is replaced by Kitasatosporales.

Update in excelSIDERITE_records

1. Removed "IUPAC Name" column because most records don't contain this item.
2. Added new Column Contributor in BI column which records the contributor (except SIDERITE team) for this record.

Note: The pictures of siderophore structures in "structure" column are no longer updated.

SIDERITE_unique_structures

1. Changed Header into Pseudomonadota from Proteobacteria.
2. Changed Header into Actinomycetota from Actinobacteria.
3. Changed Header into Bacteroidota from Bacteroidetes.
4. Changed Header into Siderophore Cluster from Siderophore Large Class.
5. Changed Header into Siderophore Group from Siderophore Class.
6. Changed Header into Siderophore Index from Siderophore Small Id.
7. Added new Column Myxococcota in AM column which is a new bacteria phylum for siderophore producers.
8. Added new Column Contributor in BQ column which records the contributor (except SIDERITE team) for this record.

Update in Siderophore Cluster

Original Cluster 5 (including SID00082, SID00141, SID00602, SID00603, SID00604, SID00605, SID00606, SID00607, SID00632, SID00633, SID00634, SID00635, SID00636, SID00637)is merged into Cluster 1.

New Cluster 5 (including SID00694, SID00695, SID00692, SID00691, SID00690, SID00689, SID00652, SID00650, SID00699, SID00698, SID00700, SID00697) and Cluster 26 (including SID00671) is added.

New siderophroes

As of 2024-5-31, there are 62 new siderophores with unique structures after the last version of SIDERITE.

Here is the list of new siderophore names:

Aeruginaldehyde

Aerugine

Aeruginol

Arthrobactin A

Avenic acid B

C12 acylated desferrioxamine+200+200+30

C12 acylated desferrioxamine+200+30

C12 acylated desferrioxamine+30

Caribactin A

Caribactin B

Caribactin C

Caribactin D

Caribactin E

Caribactin F

Chlorodactyloferrin

Dactyloferrin

Desoxy-desferrioxamine B

Desoxy-desferrioxamine D1

Didesoxy-desferrioxamine B

Didesoxy-desferrioxamine D1

Dihydroaeruginoic acid

Ethylenediamine-disuccinate

Fulvivirgamide A2

Fulvivirgamide B2

Fulvivirgamide B3

Fulvivirgamide B4

Megalochelin

Methyl 2-(2-hydroxyphenyl)-4,5-dihydrooxazole-4-carboxylate

Methyl thiazostatin B

Myxochelin B-succinate

N,N′,N′-tris(S-2,3-dihydroxybenzoyl)-O-seryl-O-seryl methoxy serinate

N,N′-bis(S-2,3-dihydroxybenzoyl)-O-seryl methoxy serinate

N-deoxy arthrobactin A

Variochelin C

Variochelin D

Variochelin E

在2024年3月21日星期四 UTC+8 20:35:00<Ruolin He> 写道：

[Ruolin He]

# SIDERITE update log in 20250131

## Fixes in website

- If there are more than one records for the siderophore, the website only shows references from the first record .
- The numbers of ligands ('Carboxylate' and 'Alpha-hydroxycarboxylate") are wrong, when these ligands are from Citrate.

## Number change
The number of SIDERITE records = 945 (last time) + 694 (new records) - 4 Deferrihydroxyneocoprogen I, Hydroxycopropen, N,N,N-triacetylfusarinin C, Serratiochelin. See "Correct and update records" for more details.) = 1635

The number of unique siderophore structures: 707 + 215 (new) - 4 ( 4 duplication: SID00374, SID00387, SID00003, SID00186) = 918

The number of Siderophore clusters: 26 - 1 (Cluster 8) + 8 (Cluster 8 and Cluster 27-33) = 33

## Archive files
SIDERITE_records_20250131.xlsx
contains 1635 siderophore records

SIDERITE_unique_structures_20250131.xlsx
contains 918 unique siderophore structures

The same siderophore structures can be found in different species, leading to multiple records. Therefore, the number of siderophore records can exceed the number of unique siderophore structures.

Non-natural_siderophore_records_20250131.xlsx
As SIDERITE is a natural product database, it doesn’t include artificial siderophores, those synthesized by supplementing precursors, or variants produced by gene knock-out strains, though we record their names and references as supplements.

They can be downloaded in zenodo: [https://doi.org/10.5281/zenodo.15335466](https://doi.org/10.5281/zenodo.15335466)

## Correct and update records
1.Corrected the structure of "Heterobactin A" (SID00595) in Rhodococcus erythropolis, and renamed it as "Heterobactin A Carrano". See two special cases section for more details.
2.Corrected the structure of "Serratiochelin" (SID00186). After correction, the structure of "Serratiochelin" and "Serratiochelin A" are same. Therefore, we merged them, and assigned "Serratiochelin" as the other name of "Serratiochelin A".
3.Corrected the structure of "Mycobactin NA (Nocobactin; Nocobactin NA)" (SID00616).
4.Corrected the structure of "Mycobactin S" (SID00599).
5.Corrected the structure of "Mycobactin J" (SID00601).
6.Corrected the structure of "Mycobactin P" (SID00600).
7.Corrected the structure of "Mirubactin" (SID00224). It's worth noting that the structure of Mirubactin in PubChem is also wrong.
8.Corrected the structure of "Be-32030A" (SID00642).
9.Corrected the structure of "Be-32030B" (SID00609).
10.Corrected the structure of "Be-32030C" (SID00610).
11.Corrected the structure of "Be-32030D" (SID00608).
12.Corrected the structure of "Deferrihydroxycoprogen" (SID00375).
13.Corrected the structure of "Deferrihydroxyneocoprogen I" (SID00374).
14.Corrected the name of "Aquachelin G" (SID00282) into "Aquachelin J" (SID00282).
15.Corrected the name of "Hydroxycopropen" (SID00387) into "Hydroxycoprogen" which is a typo in 2010 siderophore review, and merge "Hydroxycoprogen" (the other name) into "Deferrihydroxycoprogen" (SID00375).
16.Removed "Corynebactin" from the other name of "Bacillibactin", assigned it to another siderophore structure produced by Corynebacterium diphtheriae, and removed the record that Corynebacterium glutamicum can produce "Bacillibactin".
17.Removed "Linear trichrysobactin" from the other name of "Frederiksenibactin", assigned it to another siderophore structure produced by Dickeya chrysanthemi.
18.Removed "Ferrirhodin" (SID00808) from the other name of "Ferrirubin" (SID00417), assigned it to another siderophore structure. The difference between the two structures is that the order of the groups connected to the double bonds on the side chains is different.
19.Changed the biosynthetic type of Anguibactin, Preacinetobactin from Hybrid NRPS/NIS into NRPS.
20.Changed the biosynthetic type of Pseudoalterobactin A, Pseudoalterobactin B, Alterobactin A, Alterobactin B, Lystabactin A, Lystabactin B, Lystabactin C from NRPS into Hybrid NRPS/PKS.
21.Changed the biosynthetic type of Siderochelin A from NIS into PKS.
22.Changed the biosynthetic type of 2,3-dihydroxybenzoic acid, Gentisic acid, Protocatechuic acid, Salicylic acid, 3,5-dihydroxybenzoic acid, Ferroverdin A-H from NIS into Other.
23.Renamed Serratiochelins A into Serratiochelin A.
24.Renamed Serratiochelins B into Serratiochelin B.
25.Renamed Serratiochelins C into Serratiochelin C.
26.Renamed Ornibactin - C4 into Ornibactin C4.
27.Renamed Ornibactin - C6 into Ornibactin C6.
28.Renamed Ornibactin - C8 into Ornibactin C8.
29.Renamed "Pyoverdine VLB120" into "Pyoverdine VLB120 Pro" because there is another siderophore "Pyoverdine VLB120 Orn" in Pseudomonas taiwanensis VLB120.
30.Updated the SMILES for the following siderophores with additional isomeric information from PubChem.
  a.Marinobactin F (SID00291)
  b.Serobactin B (SID00534)
  c.Serobactin C (SID00535)
  d.Pacifibactin-Gly (SID00526)
  e.Talarazine A (SID00405)
  f.Talarazine C (SID00393)
  g.Talarazine D (SID00391)
  h.Talarazine E (SID00392)
  i.Vicibactin 7101 (SID00008)
  j.Coprinoferrin (SID00310)
  k.Cahuitamycin A (SID00570)
  l.Cahuitamycin B (SID00574)
  m.Cahuitamycin C (SID00573)
  n.Cahuitamycin D (SID00571)
  o.Cahuitamycin E (SID00569)
  p.Cahuitamycin F (SID00572)
  q.Heterobactin S2 (SID00597)
  r.Labrenzbactin (SID00184)
  s.Amamistatin A (SID00633)
  t.Amamistatin B (SID00632)
  u.Isopyochelin (SID00093)
  v.Pacifibactin-Ser (SID00686)
31.Updated the producer species of Anguibactin, Trivanchrobactin, Divanchrobactin,  Vanchrobactin from "Vibrio sp. DS40M4" into "Vibrio campbellii DS40M4". Refer to literature [Genome Sequence of the Marine Bacterium Vibrio campbellii DS40M4, Isolated from Open Ocean Water | Journal of Bacteriology 2012](https://journals.asm.org/doi/10.1128/jb.06583-11).
32.Updated the producer species of Sorangibactin from "Sorangiineae strain MSr11367" into "Pendulispora rubella". Refer to NCBI [Taxonomy browser (Pendulispora rubella)](https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=2741070).
33.Updated the producer species of Petrobactin, Petrobactin disulfonate, Petrobactin sulfate from "Marinobacter hydrocarbonoclasticus" into "Marinobacter nauticus". Refer to NCBI [Taxonomy browser (Marinobacter nauticus)](https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=2743).
34.Updated Phylum due to NCBI Taxonomy update: Cyanobacteria is replaced by Cyanobacteriota. Firmicutes is replaced by Bacillota.
35.Added "Amychelin A" into the other name of "Amychelin".
36.Split Thiazostatin (SID00092) into Thiazostatin A (SID00092) and Thiazostatin B (SID00919). Thiazostatin A and Thiazostatin B are a set of enantiomers.
37.Merged "N,N',N''-triacetylfusarinin C" (SID00003) into "Triacetylfusarinine" (SID00004). "N,N',N''-triacetylfusarinin C" is the format of "Triacetylfusarinine" without isomeric information.
38.Deleted SID00374, SID00387, SID00003, SID00186 due to mergence.

## Update in excel
### SIDERITE_records
1. Removed "Structure" column. Users can check the pictures of siderophore structures in the website.
2. Added new columns "NCBI Species", "Taxonomy ID". "NCBI Species" is the closest taxonomy of "Species" in NCBI, because some strains or species are not found in the NCBI. For example, if it is not found at the strain level, but can be found at the species (or genus) level, we will fill in this species (or genus) in the "NCBI Species". "Taxonomy ID" is the Taxonomy ID of "NCBI Species".
3. Now "Contributor" column includes SIDERITE team members.

### SIDERITE_unique_structures
1. Changed Header into Cyanobacteriota from Cyanobacteria.
2. Changed Header into Bacillota from Firmicutes.
3. Added new Column Zoopagomycota in AM column which is a new bacteria phylum for siderophore producers.

## Update in Siderophore Cluster
Original Cluster 8 (including SID00202, SID00203, SID00206, SID00207)is merged into Cluster 1.

New Cluster 8 (including SID00923, SID00916, SID00917, SID00918), Cluster 27 (including SID00832, SID00812, SID00804, SID00748, SID00912, SID00780), Cluster 28 (including SID00814, SID00742), Cluster 29 (including SID00716, SID00715), Cluster 30 (including SID00822, SID00714, SID00713), Cluster 31 (including SID00844), Cluster 32 (including SID00826), Cluster 33 (including SID00809) is added.

## New siderophroes
As of 2025-1-31, there are 215 new siderophores with unique structures after the last version of SIDERITE.

Here is the list of new siderophore names:

(2,3-dihydroxybenzoylserine)2

2-N-Acetylcysteine-d-lipothrenin A

2-N-Acetylcysteine-d-lipothrenin A1

3,7-dihydroxytropolone

7-hydroxytropolone

Acyl-desferrioxamine C15

Acyl-desferrioxamine C16

Amodesmycin A

Amodesmycin B

Amphibactin U

Amphibactin V

Amphiphilic coprogen 1

Amphiphilic coprogen 2

Amphiphilic coprogen 3

Amphiphilic ferrioxamine 1

Amphiphilic ferrioxamine 10

Amphiphilic ferrioxamine 11

Amphiphilic ferrioxamine 12

Amphiphilic ferrioxamine 13

Amphiphilic ferrioxamine 14

Amphiphilic ferrioxamine 15

Amphiphilic ferrioxamine 2

Amphiphilic ferrioxamine 3

Amphiphilic ferrioxamine 4

Amphiphilic ferrioxamine 5

Amphiphilic ferrioxamine 6

Amphiphilic ferrioxamine 7

Amphiphilic ferrioxamine 8

Amphiphilic ferrioxamine 9

Amychelin B

Astepyrazinoxide

Azotobactin

Azotobactin VLB120

Azotobactin delta

Bacillibactin E

Bacillibactin F

Bassianin

Be-32030E

Beauverichelin A

Bisucaberin 01

Bisucaberin 02

Bisucaberin 03

Bisucaberin 04

Bisucaberin 05

Bisucaberin 06

Bisucaberin 07

Bisucaberin 08

Bolagladin A

Bolagladin B

Carboxymycobactin T

Clonocoprogen A

Clonocoprogen B

Clonocoprogen C

Coelichelin 01

Coprogen JB370

Cordypyridone B

Corynebactin

Cyanochelin 1045

Cyanochelin A

Cyanochelin B

Desferrioxamine 01

Desferrioxamine 02

Desferrioxamine 04

Desferrioxamine 06

Desferrioxamine 07

Desferrioxamine 08

Desferrioxamine G1t

Desferrioxamine X7

Desmethylbassianin

Diacetylfusarinine A

Didehydroxy-mycobactin 810

Didehydroxy-mycobactin 812

Didehydroxy-mycobactin 838

Didehydroxy-mycobactin 840

Dihydropyoverdine I

Dimerumic acid 11-mannoside

Distal monodeoxycarboxymycobactin C7:0 (methyl) methyl ester

Distal monodeoxycarboxymycobactin C7:0 (serine) methyl ester

Distal monodeoxycarboxymycobactin C7:1 (methyl) methyl ester

Distal monodeoxycarboxymycobactin C7:1 (serine) methyl ester

Distal monodeoxycarboxymycobactin C8:1 (methyl) methyl ester

Distal monodeoxycarboxymycobactin C9:0 (methyl)

Distal monodeoxymycobactin C16:1 (α-methyl serine)

Distal monodeoxymycobactin C18:1 (serine)

Distal monodeoxymycobactin C20:0 (serine)

Distal monodeoxymycobactin C20:0 (α-methyl serine)

Distal monodeoxymycobactin C20:1 (α-methyl serine)

Distal monodeoxymycobactin C22:1 (serine)

Exochelin 772SM

Exochelin 786SM

Fabrubactin A

Fabrubactin B

Farinosone B

Fatuamide A

Fatuamide B

Ferribactin S3a20

Ferrirhodin

Foxicin A

Fradiamine C

Fradiamine D

Fumosorinone

Heterobactin A Bosello

Hexadehydro-astechrome

IC202D

Leptochelin A

Leptochelin B

Leptochelin C

Linear enterobactin

Linear monoglucosyl-enterobactin

Linear trichrysobactin

Lipothrenin A

Madurastatin E1

Madurastatin F

Madurastatin G1

Malleilactone

Marinobactin HG

Mediterraneabactin

Metachelin A-CE

Metachelin C

Methylolanthanin

Militarinone A

Mirubactin B

Mirubactin C

Mirubactin D

Mycobactin Ab

Myxochelin N1

Myxochelin N2

Nocobactin NA 10152A

Nocobactin NA 10152B

Nocobactin NA 108242

Nocobactin NA 108938

Nocobactin NA 14340

Ornibactin 790

Potashchelin A

Potashchelin B

Potashchelin C

Potashchelin D

Propionyl-ferrioxamine

Protochelin C

Protochelin D

Protochelin F

Proximal monodeoxycarboxymycobactin C7:0 (methyl) methyl ester

Proximal monodeoxycarboxymycobactin C7:0 (serine) methyl ester

Proximal monodeoxycarboxymycobactin C7:1 (methyl) methyl ester

Proximal monodeoxycarboxymycobactin C7:1 (serine) methyl ester

Proximal monodeoxycarboxymycobactin C8:1 (methyl) methyl ester

Proximal monodeoxycarboxymycobactin C9:0 (methyl)

Proximal monodeoxymycobactin C16:1 (α-methyl serine)

Proximal monodeoxymycobactin C18:1 (serine)

Proximal monodeoxymycobactin C20:0 (serine)

Proximal monodeoxymycobactin C20:0 (α-methyl serine)

Proximal monodeoxymycobactin C20:1 (α-methyl serine)

Proximal monodeoxymycobactin C22:1 (serine)

Pseudomobactin A

Pseudomobactin B

Pseudomonin A

Pseudomonin B

Pseudomonin C

Pulcherriminic acid

Pyoverdine 358

Pyoverdine Ag1

Pyoverdine B10

Pyoverdine VLB120 Orn

Rhodopetrobactin A

Rhodopetrobactin B

Ruckerbactin

Saccharochelin A

Saccharochelin B

Saccharochelin C

Saccharochelin D

Saccharochelin E

Saccharochelin F

Saccharochelin G

Saccharochelin H

Salmochelin MGE

Salmycin B

Salmycin C

Salmycin D

Siderochelin B

Siderochelin C

Siderochelin D

Spinactin A

Spinactin B

Spinactin C

Spinactin D

Spinactin E

Sporachelin A

Sporachelin A1

Sporachelin B

Sporachelin C

Sporachelin D

Sporachelin E

Synechobactin C11

Synechobactin C13

Synechobactin C14

Synechobactin C16

Synechobactin C9

Tenacibactin K

Tenacibactin L

Tenacibactin M

Tenellin

Terpenibactin A

Terpenibactin B

Terpenibactin C

Terramide A

Terramide B

Terramide C

Thiazostatin B

Thiazostatin D

Thiazostatin E

Triacetyfusarinine B

Untitled siderophore 4

Vibrioferrin B

Vibrioferrin C

dDFx[00-]

### The distribution of new siderophores by year of first report
Year Count
1974 2
1984 3
1989 1
1993 2
1995 6
1997 1
1999 1
2000 2
2001 1
2002 1
2004 5
2008 1
2011 4
2012 28
2013 17
2014 2
2015 10
2016 7
2017 4
2018 21
2020 23
2021 27
2022 13
2023 7
2024 19
2025 7

[2100012114]

# SIDERITE update log in 20251231


## Archive files
**SIDERITE_records_20251231.xlsx**
contains 1779 siderophore records,

**SIDERITE_unique_structures_20251231.xlsx**
contains 1018 unique siderophore structures

The same siderophore structures can be found in different species, leading to multiple records. Therefore, the number of siderophore records can exceed the number of unique siderophore structures.

They can be downloaded in zenodo: [https://zenodo.org/records/18327880](https://zenodo.org/records/18327880)

## Correct and update records

1. Corrected the structure of "Desferrioxamine A1A" (SID000340), and renamed it as "Desferrioxamine A1". See two special cases section for more details.

2. Updated the reference source of "Cyanochelin B" (SID000771), changing from **Falcao, Berness Peter, et al. "Cyanochelin B: A siderophore produced by cyanobacterium Leptolyngbya sp. NIES-3755 with photolytic properties that negate iron monopolization in the UV-light." bioRxiv (2025): 2025-01.** to **Falcao, Berness P., et al. "Cyanochelin B: a cyanobacterium-produced siderophore with photolytic properties that negate iron monopolization in UV light." Applied and Environmental Microbiology 91.11 (2025): e02566-24.**, which was published officially.

3. Updated the cluster information based on *Coconut* in some siderophores. See Siderite for more details.

    a. **Cluster** 5.1 → 1.58

    b. **Cluster** 5.2 → 5.1

    c. Vibrioferrin C: 9.1.9 → 3.6

    d. Untitled siderophore 4: 8.1.1 → new cluster

    e. Protocatechuic acid: 12.2.1 → new cluster

    f. 2,3-dihydroxybenzoic acid: 12.3.1 → new cluster

    g. Gentisic acid: 11.1.2 → new cluster

    h. Salicylic acid: 11.2.1 → new cluster

    i. Aerugine: 1.38.3 → 1.57

    j. Preacinetobactin: 1.3.2 → 1.4

    k. Spoxazomicin A: 1.6.4 → 1.59.1

    l. Spoxazomicin B: 1.6.3 → 1.59.2

    m. Pyochelin: 1.7.5 → 1.10.2

    n. Enantio-pyochelin: 1.7.4 → 1.10.14

    o. Thiazostatin E: 1.10.2 → 1.60

    p. Thiazostatin D: 1.10.14 → 1.60

    q. Protochelin F: 1.23.2 → 1.61.1

    r. Streptobactin: 1.24.4 → 1.62

    s. Cyclic trichrysobactin: 1.24.3 → 1.62

    t. MBJ-0035: 1.30.6 → 1.33

    u. Madurastatin C1: 1.30.7 → 1.33

    v. Coprinoferrin: 2.9.7 → 2.28

    w. NBRI16716A: 2.12.27 → 2.29

    x. NBRI16716C: 2.12.26 → 2.29

    y. Rhodotorulic acid: 2.13.24 → 2.30

    z. Sake colorant A: 2.13.18 → 2.30

    aa. Ferrichrysin: 2.13.19 → 2.30

    ab. Ferricrocin: 2.13.20 → 2.30

    ac. Ferrichrome: 2.13.21 → 2.30

    ad. Tetraglycine ferrichrome: 2.13.22 → 2.30

    ae. Ferrichrome C: 2.13.23 → 2.30

    af. Malonichrome: 2.13.17 → 2.30

    ag. Pseudonochelin: 1.30.5 → 1.63

    ah. Oxachelin: 1.30.4 → 1.63

    ai. Amychelin: 1.30.3 → 1.63

    aj. Gobichelin A: 1.30.2 → 1.63

    ak. Gobichelin B: 1.30.1 → 1.63




## New siderophroes
As of **2025-12-31**, there are **100 new** siderophores with unique structures after the last version of SIDERITE.

Here is the list of new siderophore names:

N,N′-diacetyl-fusarinine B

N-acetyl-fusarinine A

Pandorachelin

Pandorabactin A

Pandorabactin B

Viobactin

Fimsbactin G

Fimsbactin H

EDHA

Ulbactin J

Ulbactin N

Ulbactin Q

Ulbactin D

Ulbactin K

Ulbactin O

Ulbactin R

Ulbactin H

Ulbactin L

Ulbactin E

Ulbactin B

Ulbactin A

Ulbactin T

(R)-escherichelin

Ulbactin M

Ulbactin I1-I2

Ulbactin S

Ulbactin P1-P2

Coublibactin A

Coublibactin B

Coublibactin C

Lactuchelin A

Fradibactin A

Legonoxamine C

Legonoxamine D

Legonoxamine E

Legonoxamine F

Legonoxamine G

Legonoxamine H

Legonoxamine A glycoside

un-pre[5+5*]

pre[5+5*] aldehyde

Desferrioxamine D4

Deoxydesferrioxamine D3

C3 acylated desferrioxamine B

C4 acylated desferrioxamine B

C5 acylated desferrioxamine B

C4 acylated hydroxylated desferrioxamine B

uC6 acylated desferrioxamine B

C6 acylated desferrioxamine B

uC7 acylated desferrioxamine B

Dodecanedioic desferrioxamine B

Tridecanedioic desferrioxamine B

Glutaric desferrioxamine H

C2 acyl desferrioxamine H

Desferrioxamine D3

C2 acylated desferrioxamine D

C5 acylated desferrioxamine D

C7 acylated desferrioxamine D

C11 acylated desferrioxamine D

C12 acylated desferrioxamine D

C13 acylated desferrioxamine D

C14 acylated desferrioxamine D

Tenacibactin E

Tenacibactin F

Tenacibactin G

Tenacibactin H

Tenacibactin I

Tenacibactin J

C3 acylated desferrioxamine D

C7:1 acylated desferrioxamine D

C8 acylated desferrioxamine D

C13:1 acylated desferrioxamine D

C15:1 acylated desferrioxamine D

Tenacibactin-like C3

Tenacibactin-like C4

Tenacibactin-like C6

Tenacibactin-like C8

Tenacibactin-like C10:1

Tenacibactin-like C10

Tenacibactin-like C12

C11 N-succinyl-Desferrioxamine

C13 N-succinyl-Desferrioxamine

N-Butyryl-desferrioxamine B

C11 acylated desferrioxamine A1

C12 acylated desferrioxamine A1

C13 acylated desferrioxamine A1

Kasichelin A

Kasichelin B

Kasichelin C

Kasichelin D

Methylocystabactin

Serratiochelin E

Serratiochelin F

Fusariferin A

Fusariferin B

### The distribution of new siderophores by year of first report

Year        Count

2009    2

2018    1

2019    1

2021    38

2025    58