Car handling has been lightened from GTA IV and is much more enjoyable, on foot combat seems less clunky and the seamless cut scenes are very impressive - you are walking along in real time and it just switches to a cut scene without the camera angle even changing, very clever stuff. You can now also skip a mission after failing three times, handy for those horribly tough missions that drive you crazy.
I do have to say that, while I’m not a GTA fan. The skip mission stuff very much interests me especially since I have always found GTAs control suspect. However they worked well in LA Noire and if they have a story that is more interesting than previous incarnations. Given how much I have enjoyed InFamous, Assassins Creed, Red Dead & Saints Row I’m sure eventually I’ll find one GTA game I enjoy.