VanBUG March 2017: Dr. Grace Zheng - March 9th 6pm at UBC Campus, AMS NEST

[Vanessa Guerra]

Dear VanBUGger, 

Please join us on Thursday, March 9th at 6PM with Dr. Grace Zheng from 10X Genomics . Note this event is co-hosted with the Bioinformatics Program B.I.G. Research Day and will be at the UBC Point Grey Campus, AMS Student NEST, Rooms 2306/2309 . 

Title: 

"Quantitative profiling of large and complex single cell populations: applications to brain and immune cells” 

Abstract: 

The advent of high throughput, droplet based systems for assaying transcriptomes at the single cell resolution has revolutionized our approach to studying complex biological systems. We recently described a fully-integrated, droplet based approach, the ChromiumTM single cell system, that enables 3’ mRNA digital counting of up to millions of single cells. High efficiency cell capture coupled with a low doublet rate (<1% per 1000 cells) facilitates the profiling of precious and rare cell populations. We have also developed an open source analysis pipeline, Cell RangerTM, that is optimized for efficient processing of sequence data. Recently, we released an interactive analysis and visualization tool call Cell LoupeTM. 

In this talk, I will demonstrate the power of the ChromiumTM single cell system to dissect heterogeneous populations through the analysis of ~1.3 million brain cells from cortex, hippocampus and ventricular zones of 2E18 mice. In addition, I will illustrate the power of this system to track the progression of diseases through comparative analysis of AML patients undergoing hematopoietic stem cell transplant. Lastly, I will introduce an upcoming addition to the system to characterize paired T cell receptor alpha and beta chains in 10s of 1000s of T cells. 

Bio: 

Grace Zheng is a computational biologist with over 10 years of experience in genomics, RNA, and stem cell research. She received her PhD in Computational and Systems Biology from MIT and her postdoctoral training at Stanford University School of Medicine. She is currently a senior scientist at 10X Genomics, leading projects on single cell RNA-seq and linked-read technology to detect structural variants. 

Our introductory speaker is Raphael Roccor , PhD student in Dr. Lindsay Eltis and ECOSCOPE trainee at UBC. His talk is titled “ Exploiting a soil bacterium for the sustainable production of high-value lipids ”. 

For this special event, we invite trainee (students, PDFs, and RAs) to meet our featured speaker at 4PM in AMS Student NEST, Rooms 2311 to talk about science and career. 

This year, you can continue to tune in to view the VanBUG talks live online! The permanent webcast link is [ http://vidyoreplay.computecanada.ca/replay/webcastShow.html?key=TAKdbjoDvIqKdLn | http://vidyoreplay.computecanada.ca/replay/webcastShow.html?key=TAKdbjoDvIqKdLn ] . This technology is brought to you by Compute Canada and WestGrid with support from PHSA Telehelath. 

Simply point your browser at the link during the live session to view the talk live. The webcast sessions are not interactive so if you have questions for the speakers please tweet your questions @VanBUG_ and we will try to respond to your questions live. Note that there is likely a 10-15 second delay with the video. 

Sessions will also be recorded and archived with the presenters' consent and the links will be posted on the VanBUG website. 

Note that pizza, beverage and lively social interactions are not available via Webcast! So there are still good reasons to attend VanBUGs in person. 

Location: 

6133 University Blvd 

AMS Student NEST, Rooms 2306/2309 

University of British Columbia 

Date/Time: 

March 9, 2017 

Start Time: 6:00 PM (Trainee Meet the Speakers sessions start at 4PM before the talk) 

End Time: 7:30 PM (followed by drinks at Gallery 2.0) 

Contact Name: 

William Hsiao 

[ mailto:d...@vanbug.org | d...@vanbug.org ] 

[ http://vanbug.org/ | http://vanbug.org ] 

The VanBUG team: 

Cedric Chauve 

Rodrigo Goya 

William Hsiao 

Amy Lee 

Kieran O'Neill 

Raunak Shrestha 

Thea Van Rossum 

Phillip Richmond 

Sam Hinshaw 

Evan Morien 

VanBUG is generously sponsored by the UBC/SFU Bioinformatics Training Program, ECOSCOPE Training Program, MITACS, GenomeBC, and the Canadian Bioinformatics Workshops. We thank our major sponsors UBC/SFU Bioinformatics Training Program and welcome a new major sponsor, the ECOSCOPE NSERC CREATE Training Program. 

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