Punaisten pippurien aineosa kapsaisiini estää rasvasolujen kasvua
Matti Narkia
määrin paprikassakin esiintyvä kapsaisiini estää tutkimuksen
Hsu CL, Yen GC.
Effects of Capsaicin on Induction of Apoptosis and Inhibition of
Adipogenesis in 3T3-L1 Cells.
J Agric Food Chem. 2007 Mar 7;55(5):1730-6. Epub 2007 Feb 13.
PMID: 17295509 [PubMed - in process]
DOI: 10.1021/jf062912b
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17295509>
<http://pubs.acs.org/cgi-bin/sample.cgi/jafcau/2007/55/i05/html/jf062912b.html>
(koko teksti)
mukaan rasvasolujen kasvua. Aikaisemmissa tutkimuksissa kapsaisiini
oli jo yhdistetty rasvakudoksen vähenemiseen ja veren rasvapitoisuuden
alenemiseen. Uutisartikkeli
Red Pepper: Hot Stuff For Fighting Fat?
ScienceDaily March 5, 2007
<http://www.sciencedaily.com/releases/2007/03/070305092428.htm>
kommentoi tutkimusta seuraavasti:
"Food scientists in Taiwan are reporting new evidence from
laboratory experiments that capsaicin — the natural compound
that gives red pepper that spicy hot kick — can reduce the
growth of fat cells. The study is scheduled for the March 21
issue of the ACS’ Journal of Agricultural and Food Chemistry,
a bi-weekly publication.
In the report, Gow-Chin Yen and Chin-Lin Hsu cite previous
research suggesting that obesity can be reduced by preventing
immature fat cells (adipocytes) from developing into mature
cells.
Past research also linked capsaicin to a decrease in the
amount of fat tissue and decreased blood-fat levels. With
that knowledge, the researchers tested capsaicin’s effects on
pre-adipocytes and adipocytes growing in laboratory cultures.
They found that capsaicin prevented pre-adipocytes from
filling with fat and becoming full-fledged fat cells. The
effects occurred at levels just slightly greater than those
found in the stomach fluid of an individual eating a typical
Indian or Thai diet, the researchers noted. Capsaicin worked
by providing a biochemical signal that made fat cells undergo
apoptosis, a mechanism in which cells self-destruct."
Tietoa punaisista pippureista ja kapsaisiinistä:
Chili – Wikipedia
<http://fi.wikipedia.org/wiki/Chili>
Cayennepippuri – Wikipedia
<http://fi.wikipedia.org/wiki/Cayennepippuri>
Paprika – Wikipedia
<http://fi.wikipedia.org/wiki/Paprika>
Chili pepper - Wikipedia, the free encyclopedia
<http://en.wikipedia.org/wiki/Chili_pepper>
Capsicum - Wikipedia, the free encyclopedia
<http://en.wikipedia.org/wiki/Capsicum
Cayenne pepper - Wikipedia, the free encyclopedia
<http://en.wikipedia.org/wiki/Cayenne_pepper>
Paprika - Wikipedia, the free encyclopedia
<http://en.wikipedia.org/wiki/Paprika>
Kapsaisiini – Wikipedia
<http://fi.wikipedia.org/wiki/Kapsaisiini>
Capsaicin - Wikipedia, the free encyclopedia
<http://en.wikipedia.org/wiki/Capsaicin>
--
Matti Narkia
Janne
On 2007-03-06, Matti Narkia <m...@mbnet.fi> wrote:
<clip>
Saanko lainata viestisi kokonaisuudessaan harrastusfoorumillemme:
http://javu.kapsi.fi/inferno ?
- Janne
ps. muita aiheeseen liittyvivä linkkejä:
www.chiliyhdistys.info
www.fatalii.net
www.saunalahti.fi/thietavu
Matti Narkia
>
>On 2007-03-06, Matti Narkia <m...@mbnet.fi> wrote:
>
><clip>
>
>Saanko lainata viestisi kokonaisuudessaan harrastusfoorumillemme:
>
--
Matti Narkia
taija.p...@poistaostama.helsinki.fi.invalid
: They found that capsaicin prevented pre-adipocytes from
: filling with fat and becoming full-fledged fat cells. The
: effects occurred at levels just slightly greater than those
: found in the stomach fluid of an individual eating a typical
: Indian or Thai diet, the researchers noted. Capsaicin worked
: by providing a biochemical signal that made fat cells undergo
: apoptosis, a mechanism in which cells self-destruct."
Kuinkas sitten muut solut, päätyvätkö nekin apoptoosiin kapsasiinin
vaikutuksesta, vai käykö noin vain rasvasoluilla?
--
+ taija.p...@poistaostama.helsinki.fi.INVALID +
Matti Narkia
Hyvä kysymys. En suoraa mainintaa tästä vielä löytänyt, mutta
tutkimuksen mukaan rasvasolujen apoptoosia tapahtuu jo sellaisissa
kapsaiinikonsentraatioissa, jotka voidaan saavuttaa thai- tai
intialaisella ruokavaliolla. Ilmeisesti mitään ei-rasvasolujen
massiivista apoptoosia ei näissä maissa ole kuitenkaan tapahtunut,
väkiluku tuntuu vain kasvavan :-).
Tutkimuksen johdannossa mainitaan, että kapsaisiini estää myös
syöpäsolujen kasvua ja aiheuttaa nissä apoptoosia. Tässä yhteydessä
mainitaan mm. seuraavat viitteet:
Morre, D. J.; Chueh, P. J.; Morre, D. M.
Capsaicin inhibits preferentially the NADH oxidase and growth of
transformed cells in culture.
Proc. Natl. Acad. Sci. U.S.A. 1995, 92, 1831-1835.
<http://www.pnas.org/cgi/reprint/92/6/1831> (PDF)
<http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=7892186>
Macho, A.; Sancho, R.; Minassi, A.; Appendino, G.; Lawen, A.; Munoz,
E.
Involvement of reactive oxygen species in capsaicinoid-induced
apoptosis in transformed cells.
Free Radical Res. 2003, 37, 611-619
<http://www.informaworld.com/smpp/content?content=10.1080/1071576031000083215>
--
Matti Narkia
Matti Narkia
Muutama linkki lisää punaisista pippureista:
Cayenne pepper for improved blood flow
Information on using cayenne pepper to improve blood flow and other
health benefits.
<http://www.healingdaily.com/detoxification-diet/cayenne.htm>
Health Benefits of Cayenne Pepper
<http://www.whfoods.com/genpage.php?tname=foodspice&dbid=140>
WHAT'S THAT STUFF? - RED-HOT CHILI PEPPERS
The chemical capsaicin makes peppers hot; the best antidote may be ice
cream.
<http://pubs.acs.org/cen/whatstuff/stuff/8144peppers.html>
The Chemistry of Chilli Peppers
<http://www.chemsoc.org/exemplarchem/entries/mbellringer/>
NMSU is home to the world’s hottest chile pepper
<http://www.nmsu.edu/~ucomm/Releases/2007/february/hottest_chile.htm>
World's hottest chili pepper a mouthful for prof
<http://edition.cnn.com/2007/US/02/23/hot.pepper.ap/index.html?eref=rss_offbeat>
Peppers Guide
<http://users.visi.net/~mandy/pepguide.html>
HOT N' SPICY and Beverage
<http://users.visi.net/~mandy/food.html>
Open Directory - Home: Cooking: Chili
<http://dmoz.org/Home/Cooking/Chili/>
Americans Cooked With Chili Peppers 6,000 Years Ago, Study Finds
<http://news.nationalgeographic.com/news/2007/02/070215-chili-peppers.html>
Red hot chili pepper research spices up historical record
Archaeologists trace domestication and dispersal of Capsicum species
<http://www.eurekalert.org/pub_releases/2007-02/uoc-rhc020907.php>
Americans Cultivated And Traded Chili Peppers 6,000 Years Ago
<http://www.sciencedaily.com/releases/2007/02/070215144334.htm>
--
Matti Narkia
Matti Narkia
Kapsaisiinin syövänvastaisesta, syöpäsoluissa apoptoosia aiheuttavasta
vaikutuksets löytyi lisää viitteitä. Tutkimuksen
Chow J, Norng M, Zhang J, Chai J.
TRPV6 mediates capsaicin-induced apoptosis in gastric cancer
cells-Mechanisms behind a possible new "hot" cancer treatment.
Biochim Biophys Acta. 2007 Jan 10; [Epub ahead of print]
PMID: 17292493 [PubMed - as supplied by publisher]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17292493>
abstraktin mukaan kapsaisiini kuitenkin saattaa aiheuttaa apoptoosia
myös normaaleissa epiteelisoluissa, mutta vähäisemmässä määrin kuin
syöpäsoluissa. Oheisena tuo abstrakti:
"Capsaicin is an organic compound in chili peppers which are
consumed by over one quarter of the world's population daily.
Studies have shown that capsaicin can induce apoptosis in
some cancer cells by unknown mechanisms. In this study, both
gastric cancer and normal epithelial cells were treated with
capsaicin and examined for apoptosis by Annexin V binding.
Our results showed that capsaicin induces apoptosis in both
cells, although cancer cells are more susceptible. This
susceptibility is dependent on the availability of TRPV6, a
calcium-selective channel protein, as overexpression of TRPV6
in normal cells increased capsaicin-induced apoptosis and
knockdown of TRPV6 in cancer cells suppressed this action.
Our results further demonstrated that capsaicin increases
mitochondrial permeability through activation of Bax and p53
in a JNK-dependent manner. Conclusions: (1) TRPV6, rather
than TRPV1 (the well-known capsaicin receptor), mediates
capsaicin-induced apoptosis in gastric cells; (2) abundance
of TRPV6 in gastric cells determines their live or death
under capsaicin treatment; and (3) capsaicin induces
apoptosis by stabilization of p53 through JNK activation.
Together, our data suggest that capsaicin may be a promising
dietary candidate for cancer chemoprevention."
Muita viitteitä kapsaisiinista ja syövästä:
Jun HS, Park T, Lee CK, Kang MK, Park MS, Kang HI, Surh YJ, Kim OH.
Capsaicin induced apoptosis of B16-F10 melanoma cells through
down-regulation of Bcl-2.
Food Chem Toxicol. 2006 Oct 27; [Epub ahead of print]
PMID: 17306913 [PubMed - as supplied by publisher]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17306913>
Wu CC, Lin JP, Yang JS, Chou ST, Chen SC, Lin YT, Lin HL, Chung JG.
Capsaicin induced cell cycle arrest and apoptosis in human esophagus
epidermoid carcinoma CE 81T/VGH cells through the elevation of
intracellular reactive oxygen species and Ca2+ productions and
caspase-3 activation.
Mutat Res. 2006 Oct 10;601(1-2):71-82. Epub 2006 Aug 30.
PMID: 16942782 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16942782>
Tsou MF, Lu HF, Chen SC, Wu LT, Chen YS, Kuo HM, Lin SS, Chung JG.
Involvement of Bax, Bcl-2, Ca2+ and caspase-3 in capsaicin-induced
apoptosis of human leukemia HL-60 cells.
Anticancer Res. 2006 May-Jun;26(3A):1965-71.
PMID: 16827131 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16827131>
Mori A, Lehmann S, O'Kelly J, Kumagai T, Desmond JC, Pervan M, McBride
WH, Kizaki M, Koeffler HP.
Capsaicin, a component of red peppers, inhibits the growth of
androgen-independent, p53 mutant prostate cancer cells.
Cancer Res. 2006 Mar 15;66(6):3222-9.
PMID: 16540674 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16540674>
Sanchez AM, Sanchez MG, Malagarie-Cazenave S, Olea N, Diaz-Laviada I.
Induction of apoptosis in prostate tumor PC-3 cells and inhibition of
xenograft prostate tumor growth by the vanilloid capsaicin.
Apoptosis. 2006 Jan;11(1):89-99.
PMID: 16374544 [PubMed - in process]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16374544>
<http://www.springerlink.com/content/p578737p9691652h/>
Gong XF, Wang MW, Ikejima T.
[Mechanisms of capsaicin-induced apoptosis of human melanoma A375-S2
cells]
Zhonghua Zhong Liu Za Zhi. 2005 Jul;27(7):401-3. Chinese.
PMID: 16188123 [PubMed - in process]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16188123>
Kim JA, Kang YS, Lee YS.
A phospholipase C-dependent intracellular Ca2+ release pathway
mediates the capsaicin-induced apoptosis in HepG2 human hepatoma
cells.
Arch Pharm Res. 2005 Jan;28(1):73-80.
PMID: 15742812 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15742812>
Qiao S, Li W, Tsubouchi R, Haneda M, Murakami K, Yoshino M.
Involvement of peroxynitrite in capsaicin-induced apoptosis of C6
glioma cells.
Neurosci Res. 2005 Feb;51(2):175-83.
PMID: 15681035 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15681035>
Kim CS, Park WH, Park JY, Kang JH, Kim MO, Kawada T, Yoo H, Han IS, Yu
R.
Capsaicin, a spicy component of hot pepper, induces apoptosis by
activation of the peroxisome proliferator-activated receptor gamma in
HT-29 human colon cancer cells.
J Med Food. 2004 Fall;7(3):267-73.
PMID: 15383218 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15383218>
Galati G, O'Brien PJ.
Cytoprotective and anticancer properties of coenzyme Q versus
capsaicin.
Biofactors. 2003;18(1-4):195-205.
PMID: 14695935 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14695935>
--
Matti Narkia
Juhana Harju
: Kapsaisiinin syövänvastaisesta, syöpäsoluissa apoptoosia aiheuttavasta
: vaikutuksets löytyi lisää viitteitä. Tutkimuksen
En käynyt kaikkia noita linkkejäsi läpi, mutta olen joitakin kertoja
törmännyt myös tutkimuksiin, joissa mainitaan kapsaisiiniin liittyviä
riskejä. Esimerkiksi tässä tiedostossa, jossa kommentoidaan spesifisti
kapsaisiini-sprayta, viitataan kapsaisiinin mahdolliseen karsinogeenisuuteen
ja mutageenisuuteen. Tiedosto on kieltämättä vanha, mutta tutkimukset,
joihin siinä viitataan, ovat tuskin silti täysin menettäneet relevanssiaan.
http://www.cprc.org/tm/tm-01-98.pdf
--
Juhana
Matti Narkia
Vaikea sanoa. Epidemiologisten tutkimusten tulokset chilin ja syövän
yhteydestä ovat olleet jonkin verran ristiriitaisia ja positiivisia
yhteyksiäkin on löytynyt, mutta kausaalisuutta ne eivät tietysti
osoita. Miltei kaikki uusimmat tutkimukset kuitenkin mainitsevat
kapsaisiinin olevan antikarsinogeeninen ja antimutageeninen. Tässä
joitakin esimerkkejä:
Jun HS, Park T, Lee CK, Kang MK, Park MS, Kang HI, Surh YJ, Kim OH.
Capsaicin induced apoptosis of B16-F10 melanoma cells through
down-regulation of Bcl-2.
Food Chem Toxicol. 2006 Oct 27; [Epub ahead of print]
PMID: 17306913 [PubMed - as supplied by publisher]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17306913>
"Capsaicin (8-methyl-N-vanillyl-6-nonenamide), a pungent
ingredient of hot chili peppers, has been reported to possess
substantial anticarcinogenic and antimutagenic activities. ..."
Wu CC, Lin JP, Yang JS, Chou ST, Chen SC, Lin YT, Lin HL, Chung JG.
Capsaicin induced cell cycle arrest and apoptosis in human esophagus
epidermoid carcinoma CE 81T/VGH cells through the elevation of
intracellular reactive oxygen species and Ca2+ productions and
caspase-3 activation.
Mutat Res. 2006 Oct 10;601(1-2):71-82. Epub 2006 Aug 30.
PMID: 16942782 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16942782>
"Capsaicin (N-vanillyl-8-methyl-1-nonenamide) is found in pungent
fruits, especially in red pepper. Many studies have focused on the
anticarcinogenic, antimutagenic or chemopreventive activities of
capsaicin. .. "
Surh YJ.
Anti-tumor promoting potential of selected spice ingredients with
antioxidative and anti-inflammatory activities: a short review.
Food Chem Toxicol. 2002 Aug;40(8):1091-7. Review.
PMID: 12067569 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12067569>
"A wide variety of phenolic substances derived from spice
possess potent antimutagenic and anticarcinogenic activities.
Examples are curcumin, a yellow colouring agent, contained in
turmeric (Curcuma longa L., Zingiberaceae), [6]-gingerol, a
pungent ingredient present in ginger (Zingiber officinale
Roscoe, Zingiberaceae) and capsaicin, a principal pungent
principle of hot chili pepper (Capsicum annuum L,
Solanaceae). The chemopreventive effects exerted by these
phytochemicals are often associated with their antioxidative
and anti-inflammatory activities. ..."
Kapsaisiini estää tulehdusentsyymi 5-lipoksygenaasia (5-LOX, 5-LO):
Prasad NS, Raghavendra R, Lokesh BR, Naidu KA.
Spice phenolics inhibit human PMNL 5-lipoxygenase.
Prostaglandins Leukot Essent Fatty Acids. 2004 Jun;70(6):521-8.
PMID: 15120715 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15120715>
Kapsaisiini estää myös NF-kappaB:n aktivoitumisen, mitä nykyään
pidetään eräänä kohteena syövän ehkäisysessä ja ehkä joskus vielä
hoidossakin:
Mori A, Lehmann S, O'Kelly J, Kumagai T, Desmond JC, Pervan M, McBride
WH, Kizaki M, Koeffler HP.
Capsaicin, a component of red peppers, inhibits the growth of
androgen-independent, p53 mutant prostate cancer cells.
Cancer Res. 2006 Mar 15;66(6):3222-9.
PMID: 16540674 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=16540674>
"... Capsaicin inhibited NF-kappa activation by preventing
its nuclear migration. In further studies, capsaicin
inhibited tumor necrosis factor-alpha-stimulated degradation
of IkappaBalpha in PC-3 cells, which was associated with the
inhibition of proteasome activity. Taken together, capsaicin
inhibits proteasome activity which suppressed the degradation
of IkappaBalpha, preventing the activation of NF-kappaB.
Capsaicin, when given orally, significantly slowed the growth
of PC-3 prostate cancer xenografts as measured by size [75
+/- 35 versus 336 +/- 123 mm(3) (+/-SD); P = 0.017] and
weight [203 +/- 41 versus 373 +/- 52 mg (+/-SD); P = 0.0006;
capsaicin-treated versus vehicle-treated mice, respectively].
In summary, our data suggests that capsaicin, or a related
analogue, may have a role in the management of prostate
cancer."
--
Matti Narkia
Matti Narkia
>
>Kapsaisiini estää tulehdusentsyymi 5-lipoksygenaasia (5-LOX, 5-LO):
>
>Prasad NS, Raghavendra R, Lokesh BR, Naidu KA.
>Spice phenolics inhibit human PMNL 5-lipoxygenase.
>Prostaglandins Leukot Essent Fatty Acids. 2004 Jun;70(6):521-8.
>PMID: 15120715 [PubMed - indexed for MEDLINE]
><http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=15120715>
>
vaikutusta: se estää sen indusoitumista ja ilmentymää ja siten myös
tulehdusprostaglandiini PGE2:n tuotantoa. Viitteitä tästä:
Chen CW, Lee ST, Wu WT, Fu WM, Ho FM, Lin WW.
Signal transduction for inhibition of inducible nitric oxide synthase
and cyclooxygenase-2 induction by capsaicin and related analogs in
macrophages.
Br J Pharmacol. 2003 Nov;140(6):1077-87. Epub 2003 Oct 6.
PMID: 14530214 [PubMed - indexed for MEDLINE]
<http://www.nature.com/bjp/journal/v140/n6/abs/0705533a.html>
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14530214>
"... Capsaicin also transcriptionally inhibited LPS- and PMA-
induced COX-2 expression and PGE2 production.
[...]
In conclusion, vanilloids can modulate the expression of
inflammatory iNOS and COX-2 genes in macrophages through
interference with upstream signalling events of LPS and IFN-
gamma. These findings provide new insights into the potential
benefits of the active ingredient in hot chilli peppers in
inflammatory conditions."
Park JS, Choi MA, Kim BS, Han IS, Kurata T, Yu R.
Capsaicin protects against ethanol-induced oxidative injury in the
gastric mucosa of rats.
Life Sci. 2000 Nov 10;67(25):3087-93.
PMID: 11125845 [PubMed - indexed for MEDLINE]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=11125845&dopt=Abstract>
"... The expression level of cyclooxygenase-2, which
increases in inflammatory region, was determined by Western
blot analysis. Capsaicin significantly suppressed gastric
haemorrhagic erosions induced by ethanol. Capsaicin inhibited
lipid peroxidation and myeloperoxidase activity in ethanol-
induced gastric mucosal lesion in a dose-dependent manner.
Capsaicin also inhibited the expression of cyclooxygenase-2
in the gastric mucosal lesion. The gastroprotective activity
of capsaicin on the ethanol-induced oxidative damage may be
important for chemoprevention. ..."
--
Matti Narkia
Matti Narkia
Otanpa tähän myös tutkimuksen
Athanasiou A, Smith PA, Vakilpour S, Kumaran NM, Turner AE, Bagiokou
D, Layfield R, Ray DE, Westwell AD, Alexander SP, Kendall DA, Lobo DN,
Watson SA, Lophatanon A, Muir KA, Guo DA, Bates TE.
Vanilloid receptor agonists and antagonists are mitochondrial
inhibitors: how vanilloids cause non-vanilloid receptor mediated cell
death.
Biochem Biophys Res Commun. 2007 Mar 2;354(1):50-5. Epub 2007 Jan 2.
PMID: 17214968 [PubMed - in process]
<http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17214968>,
Josta löytyi tämä BBC:n uutisartikkeli:
How spicy foods can kill cancers
<http://news.bbc.co.uk/2/hi/health/6244715.stm>
"Scientists have discovered the key to the ability of spicy
foods to kill cancer cells.
They found capsaicin, an ingredient of jalapeno peppers,
triggers cancer cell death by attacking mitochondria - the
cells' energy-generating boiler rooms.
The research raises the possibility that other cancer drugs
could be developed to target mitochondria.
The Nottingham University study features in Biochemical and
Biophysical Research Communications.
The study showed that the family of molecules to which
capsaicin belongs, the vanilloids, bind to proteins in the
cancer cell mitochondria to trigger apoptosis, or cell death,
without harming surrounding healthy cells.
Capsaicin was tested on cultures of human lung cancer cells
and on pancreatic cancers.
Lead researcher Dr Timothy Bates said: "As these compounds
attack the very heart of the tumour cells, we believe that we
have in effect discovered a fundamental 'Achilles heel' for
all cancers.
"The biochemistry of the mitochondria in cancer cells is very
different from that in normal cells.
"This is an innate selective vulnerability of cancer cells."
He said a dose of capsaicin that could cause a cancer cell to
enter apoptosis, would not have the same effect on a normal
cell. ..."
--
Matti Narkia
Matti Narkia
Punaisten pippurien tulisuutta mitataan Scovillen asteikolla:
Scoville scale - Wikipedia, the free encyclopedia
<http://en.wikipedia.org/wiki/Scoville_scale>
"The Scoville scale is a measure of the "hotness" of a chili
pepper. These fruits of the Capsicum genus contain capsaicin,
a chemical compound which stimulates thermoreceptor nerve
endings in the skin, especially the mucus membranes. The
number of Scoville heat units (SHU) indicates the amount of
capsaicin present. Many hot sauces use their Scoville rating
in advertising as a selling point. The scale is named after
its creator, American chemist Wilbur Scoville."
The Scoville Heat Scale
<http://www.chilliworld.com/FactFile/Scoville_Scale.asp>
--
Matti Narkia
Matti Narkia
Lisää linkkejä:
Paprikatietoutta
<http://www.finfood.fi/finfood/kasvikset.nsf/2cb94ba131b50f0bc2256dfa003b8fc6/4cdf3b948dff9fb1c2256f5e00364a34?OpenDocument>
Ratkiriemukkaat päiväni - Chili
<http://www.kaakko.org/blogi/?cat=13>
The Chile Pepper Institute
NMSU College of Agriculture and Home Economics
<http://spectre.nmsu.edu/dept/welcome.html?t=chile>
--
Matti Narkia
Matti Narkia
Vielä pari viitettä:
Surh YJ.
More than spice: capsaicin in hot chili peppers makes tumor cells
commit suicide.
J Natl Cancer Inst. 2002 Sep 4;94(17):1263-5.
PMID: 12208886 [PubMed - indexed for MEDLINE]
<http://jnci.oxfordjournals.org/cgi/content/full/94/17/1263>
<http://jnci.oxfordjournals.org/cgi/reprint/jnci%3b94/17/1263.pdf>
"... The role of capsaicin in carcinogenic processes is quite
controversial. Although some investigators suspect that
capsaicin is a carcinogen, co-carcinogen, or tumor promoter,
others have reported that it has chemopreventive and
chemotherapeutic effects [reviewed in (4–8) and references
therein]. Interestingly, capsaicin has been found to
preferentially repress the growth of some transformed human
and mouse cells (9,10). Although the antiproliferative
activity of capsaicin has been ascribed to its ability to
induce apoptosis (9–18), relatively little is known about the
molecular basis for the programmed cell death induced by this
edible phytochemical. In an excellent study published in this
issue of the Journal, Hail and Lotan (19) have conducted a
series of elegant experiments that afford important insights
into mechanisms underlying the apoptogenic action of
capsaicin at the cellular level. The authors report that
capsaicin-induced apoptosis in cultured cells derived from
human cutaneous squamous cell carcinoma (SCC) occurs through
inhibition of mitochondrial respiration. ..."
Hail N Jr, Lotan R.
Examining the role of mitochondrial respiration in vanilloid-induced
apoptosis.
J Natl Cancer Inst. 2002 Sep 4;94(17):1281-92.
PMID: 12208893 [PubMed - indexed for MEDLINE]
<http://jnci.oxfordjournals.org/cgi/content/full/94/17/1281?ijkey=6271143817c0e5c26d92f3b7c67cb9362de4505a>
"BACKGROUND: The vanilloids capsaicin and resiniferatoxin are
natural products that contain a vanillyl moiety (4-hydroxy-3-
methoxybenzyl). Both vanilloids can induce apoptosis in
certain cell types by a mechanism that has not been fully
elucidated but may involve plasma membrane or mitochondrial
targets. We investigated the role of mitochondrial
respiration in vanilloid-induced apoptosis. METHODS:
Cytofluorometric analysis was used to evaluate the effects of
vanilloids on apoptosis, Ca(2+) mobilization, hydroperoxide
generation, and DNA content in cells from two human cutaneous
squamous cell carcinoma (SCC) cell lines (parental cells) and
in their respiration-deficient clones. Oxygen consumption by
the cells was determined polarographically. RESULTS: The
majority of the parental SCC cells underwent apoptosis after
a 12-hour exposure to 100 micro M capsaicin or 10 micro M
resiniferatoxin. The induction of apoptosis was associated
with the mitochondrial permeability transition (i.e., an
increase in the permeability of the inner mitochondrial
membrane associated with the opening of a nonspecific pore).
Exposure of parental cells to either vanilloid was not
associated with an increase in intracellular free Ca(2+)
levels but was associated with a rapid increase in
hydroperoxide generation and a decrease in oxygen
consumption. After vanilloid treatment, the respiration-
deficient clones generated less hydroperoxide and were
resistant to the mitochondrial permeability transition and
the induction of apoptosis. Moreover, vanilloid treatment
inhibited cell proliferation in the respiration-deficient
clones by promoting G(1) arrest. CONCLUSIONS: Vanilloid-
induced apoptosis in the parental SCC cells appears to
involve the inhibition of mitochondrial respiration. The
apoptogenic effects promoted by vanilloid treatment in
parental SCC cells, as well as the antiproliferative effects
observed in their respiration-deficient clones, suggest that
vanilloids may be useful for preventing or treating skin
cancers or other hyperproliferative skin disorders."
--
Matti Narkia