Kaj Stenberg vastaan evotiedemiehet EyreWalker ja Keightley

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Eyre-Walker/Keightley's Degeneration

Eyre-Walker, A. and P. Keightley. 1999. High genomic deleterious mutation
rates in Hominids.
Nature 397:344-347.

"Under conservative assumptions, we estimate that an average of 4.2
amino-acid-altering mutations per diploid per generation have occurred in
the human lineage."

"...close to the upper limit tolerable by a species such as humans. a large
number of slightly deleterious mutations may therefore have become fixed
in hominid lineages.
it is difficult to explain how human populations could have survived ... a
high rate of deleterious mutation (U >>1) is paradoxical in a species
with a low reproductive rate. If a significant fraction of new mutations is
mildly deleterious, these may accumulate. leading to gradual decline in
fitness."

"...deleterious mutations rate appears to be so high in humans and our
close relatives that it is doubtful that such species could survive."

"...the level of constraint in hominid protein-coding sequences is very low,
roughly half of all new non-synonymous mutations appear to have been
accepted ... if deleterious new mutations are accumulating at present, this
could have damaging consequences for human health."

These authors are still underestimating the extent of the mutation problem.
They only consider the mutations within the protein-encoding portion of the
genome. The functional genome is at least 10 - 30 fold larger than this.

Even with these lower mutation rate estimates, they acknowledge a
fundamental problem and conclude that many deleterious mutations have
accumulated during human evolution, and are probably still accumulating.
Doesn't this clearly demonstrate that we are in fact degenerating and
not evolving?
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Sanford, liite 1.
Kaj Stenberg, joko olet käynyt kertomassa evotovereillesi Eyre-Walkerille ja
Keightleylle, että ovat väärässä koska kimalainen osaa lentää???

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