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Background: Brain serotonin function is thought to promote sleep regulation and cognitive processes, whereas sleep abnormalities and subsequent behavioral decline are often attributed to deficient brain serotonin activity. Brain uptake of the serotonin precursor tryptophan is dependent on nutrients that influence the availability of tryptophan via a change in the ratio of plasma tryptophan to the sum of the other large neutral amino acids (Trp:LNAA).
Objective: We tested whether evening consumption of alpha-lactalbumin protein with an enriched tryptophan content of 4.8 g/100 g increases plasma Trp:LNAA and improves alertness and performance on the morning after sleep, particularly in subjects with sleep complaints.
Design: Healthy subjects with (n = 14) or without (n = 14) mild sleep complaints participated in a double-blind, placebo-controlled study. The subjects slept at the laboratory for 2 separate nights so that morning performance could be evaluated after an evening diet containing either tryptophan-rich alpha-lactalbumin or tryptophan-low placebo protein. Evening dietary changes in plasma Trp:LNAA were measured. Behavioral (reaction time and errors) and brain measures of attention were recorded during a continuous performance task.
Conclusion: Evening dietary increases in plasma tryptophan availability for uptake into the brain enhance sustained alertness early in the morning after an overnight sleep, most likely because of improved sleep.
When it came to the prostitution business, one thing that was its hardest competitors were the O/B/A system. A great majority of Alphas enjoyed regular Alpha on Omega sex because of the stimulus they get from each other. Unfortunately for the business, it seems that most of their consumers are Betas, and even the most loyal of them only have a little bit above minimum wage jobs. Somehow, they'd have to find a way to get on equal ground with each other, and like always, technology catches up fast. Simon is a new one of a kind sex android that is programmed and made to imitate the intercourse of an omega in heat, and it seems that everyone in the area has come to check out his new quirks.
Alpha! Markus x Omega! Simon
Connor looks at Markus. "Why do you want me to wear it? This is your sweater though." The omega ask the alpha. "Connor, I want you to wear it. You looked like you were freezeing. What do you think you I put this just because?"
With Hank hospitalized, Connor is reassigned to up-and-coming young agent Reina for the time being. As they scour Detroit in pursuit of deviants, both face internal struggles about the relationship between pain and what it means to be human. Connor discovers by experience that the definitions of alive, sentience, and feeling are more than just facts stored in his data base, while his partner struggles with trauma in her past regarding what happens when free will goes sideways.
Part two of my Deviant Dynamics story. Its not necessary for you to read this second part. If you want to remain happy and nice, then you probably shouldn't read part two. However, it is advised you read Deviant Dynamics before you read this story as part one explains all the dynamics and how the world works.
It's hot. The blanket Connor kicked off is nearly touching the floor away from his body. His clothes are abandoned on the corner of the room, the sweat on Connor's body dripping down and covering him in an attempt to cool; but the internal heat made it feel as if it was boiling the liquid on his skin. Making him feel hotter as he pants miserably.
After the androids have gained their freedom, Connor returns to work at the police force with his partner Hank. Everything seemed to be going as smoothly as a post-revolution can go, until Markus brings RK900 into the mix.
A Universe where humans have their own ABO dynamics and most androids were programmed to be betas. Only special models of androids were programmed with either Omega or Alpha dynamics. I will explain more on the finer details as the story progresses.
Background: Increased brain serotonin may improve the ability to cope with stress, whereas a decline in serotonin activity is involved in depressive mood. The uptake of the serotonin precursor, tryptophan, into the brain is dependent on nutrients that influence the cerebral availability of tryptophan via a change in the ratio of plasma tryptophan to the sum of the other large neutral amino acids (Trp-LNAA ratio). Therefore, a diet-induced increase in tryptophan availability may increase brain serotonin synthesis and improve coping and mood, particularly in stress-vulnerable subjects.
Objective: We tested whether alpha-lactalbumin, a whey protein with a high tryptophan content, may increase the plasma Trp-LNAA ratio and reduce depressive mood and cortisol concentrations in stress-vulnerable subjects under acute stress.
Design: Twenty-nine highly stress-vulnerable subjects and 29 relatively stress-invulnerable subjects participated in a double-blind, placebo-controlled study. Subjects were exposed to experimental stress after the intake of a diet enriched with either alpha-lactalbumin or sodium-caseinate. Diet-induced changes in the plasma Trp-LNAA ratio and prolactin were measured. Changes in mood, pulse rate, skin conductance, and cortisol concentrations were assessed before and after the stressor.
Conclusions: Consumption of a dietary protein enriched in tryptophan increased the plasma Trp-LNAA ratio and, in stress-vulnerable subjects, improved coping ability, probably through alterations in brain serotonin.
This paper investigates the alpha generation of the hedge fund industry based on a recent sample compiled from the Lipper/TASS database covering the time period from January 1994 to September 2008. We find a positive average hedge fund alpha in the cross-section for the majority of strategies and a positive and significant alpha for roughly half of all funds. Moreover, the alpha of three-quarter of the strategy indices is positive and significant in the time series. A comparison of a factor model in which the risk factors are selected based on a stepwise regression approach and the widely used factor model proposed by Fung and Hsieh (2004) reveals that the estimated alpha is robust with respect to the choice of the factor model. In contrast to prior research, we find no evidence of a decreasing hedge fund alpha over time. Moreover, based on our sample, we cannot confirm prior evidence pointing to capacity constraints in the hedge fund industry.
It is important to integrate research advances into the care of patients. Oncology is a rapidly evolving discipline. Novel approaches to the diagnosis and management of cancer have resulted in remarkable improvements in the last several years. Malignancies for which there had been no good treatments and dismal prognoses can now often be rendered chronic and sometimes cured. I feel that patients should have access to state-of-the-art treatments and have access to clinical trials that may offer even better outcomes.
Dr. Maurice Markus is a board-certified medical oncologist and hematologist. He joined the Colorado Springs location of Rocky Mountain Cancer Centers in 2007. Dr. Markus has a strong interest in genitourinary cancers. A collaborative approach to care is important to Dr. Markus\u2019s practice strategy. He is active on multiple tumor boards, working closely with pathologists, radiologists, surgeons, radiation oncologists, and other subspecialties. In presenting and consulting on cancer cases, Dr. Markus can ensure his patients have the benefit of shared knowledge from multiple experts in planning their cancer treatment options. He has a true passion for treating his patients with compassion and understanding. He strives to provide evidence-based, cutting-edge treatment options to his patients." } }, "@type": "Question", "@id": " -markus#Physician_Question2", "name": "Care Philosophy", "position": 2, "acceptedAnswer": "@type": "Answer", "@id": " -markus#Physician_Question2_Answer2", "text": "It is important to integrate research advances into the care of patients. Oncology is a rapidly evolving discipline. Novel approaches to the diagnosis and management of cancer have resulted in remarkable improvements in the last several years. Malignancies for which there had been no good treatments and dismal prognoses can now often be rendered chronic and sometimes cured. I feel that patients should have access to state-of-the-art treatments and have access to clinical trials that may offer even better outcomes." , { "@type": "Question", "@id": " -markus#Physician_Question3", "name": "Areas Served", "position": 3, "acceptedAnswer": { "@type": "Answer", "@id": " -markus#Physician_Question3_Answer3", "text": "Colorado Springs, CO
N2 - Cytokines play an important role in the regulation of homeostasis and inflammation. A de-regulated cytokine function can subsequently promote chronic inflammation. This is supported by clinical evidence showing the beneficial effect of inhibiting TNF-alpha through injection of antibodies and soluble receptor in disorders such as rheumatoid arthritis and Crohn's disease. Systemic anti-TNF-alpha therapy however is associated with infectious complications. We therefore suggest a concept for the local deposition of therapeutically active agents into areas of inflammation or malignancy, based on the use of hematopoietic storage and secretory granules as delivery vehicles. Hematopoietic cells are induced to express the therapeutically active protein and to store it in the secretory lysosomes. The cells migrate into a tumour or site of inflammation, where the cells become activated and release the contents of their secretory lysosomes resulting in the local delivery of the therapeutically active protein. In support of this concept, gene transfer and granule loading can be achieved using the soluble TNF-alpha receptor (sTNFR1) after cDNA expression in hematopoietic cell lines. Endoplasmic reticulum (ER)-export can be facilitated by the addition of a transmembrane domain, and constitutive secretion can be prevented by incorporating a cytosol-sorting signal resulting in secretory lysosome targeting. The sTNFR1 is released from the transmembrane domain by proteolytic cleavage and finally, regulated sTNFR1-secretion can be triggered by a calcium signal. In vivo investigations are currently determining the feasibility of local protein delivery at sites of inflammation.
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