I'm quite sure I've used the bindings in console and WinForms applications. I don't recall trying it in a WPF app. Since you're using VS 2012, I'd make sure I was targeting .NET 3.5 or 4.0, just to eliminate that as a possible problem. It should be a fairly simple matter to throw together a WPF form with only a button that runs a simple WebDriver test method. Since you haven't seen fit to share any code, it's difficult to make more specific recommendations.