PhD Studentship in infection biology and proteomics of bovine

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David MacHugh

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Apr 13, 2010, 11:06:33 AM4/13/10
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PhD Studentship in infection biology and proteomics of bovine
tuberculosis
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A four-year PhD studentship in infection biology and proteomics of
bovine tuberculosis is available at the Animal Genomics Laboratory,
University College Dublin. Applicants should have a 2.1 honours degree
or higher in one of the following disciplines: Biochemistry,
Chemistry, Cell Biology, Structural Biology, Immunology, Genetics/
Genomics or Microbiology.


Description of the Research Project
---------------------------------------------------

Tuberculosis is a devastating disease of humans and animals. Bovine
tuberculosis, caused by Mycobacterium bovis, is a major zoonotic
pathogen and causes losses to global agriculture of approx. ^À2.2
billion per annum. In order to develop strategies to control
tuberculosis, we need to understand how the pathogen causes disease.
This PhD project will explore the host response to M. bovis and will
focus on in vitro and in vivo studies of the bovine macrophage and
interactions with M. bovis mycobacteria. Methods to be applied will
include cell culture, multidimensional protein identification
technology (MudPIT - http://tinyurl.com/y7dlm69) and mass
spectrometry, quantitative proteomics (iTRAQ - http://tinyurl.com/y4hnlwd),
multiplex cytokine ELISA analysis (http://tinyurl.com/y5jcwuc) and
bioinformatics.
The successful applicant will join a large group of researchers
investigating bovine tuberculosis, and will have access to outstanding
research facilities at the Animal Genomics Laboratory, UCD School of
Agriculture, Food Science and Veterinary Medicine and at the UCD
Conway Institute of Biomolecular and Biomedical Research.
The students will also be enrolled in the UCD Thematic PhD programme
in Infection Biology (for more information see: http://www.ucd.ie/infectbio).

Student stipends will start at ^À16,850 and postgraduate fees will be
funded separately.


Application procedure
-------------------------------

Applications (covering letter, CV and contact details for two
laboratory and/or academic referees) should be emailed in MS Word or
PDF format to tbprot...@gmail.com.

Further scientific information can also be obtained by contacting
David MacHugh or Stephen Gordon (see below).

Proposed start-date: September/October 2010

Unfortunately due to funding restrictions, this position is
available to EU residents only. Applications from non-EU residents
will not be short-listed.

Deadline for applications: Friday, June 11th 2010

Prof. David MacHugh PhD,
Animal Genomics Laboratory,
School of Agriculture, Food Science,
and Veterinary Medicine,
University College Dublin (UCD).
Phone: +353-1-716-6256
Email: david....@ucd.ie
Web: http://www.animalgenomics.ucd.ie

Prof. Stephen Gordon PhD,
Molecular Microbiology Laboratory,
School of Agriculture, Food Science,
and Veterinary Medicine,
University College Dublin (UCD).
Phone: +353-1-716-6181
Email: stephen...@ucd.ie
Web: http://www.ucd.ie/infectbio

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