Seminar & Short Course

[Barron, Alfred [PRI]]

The New Jersey Chapter, American Statistical Association
announces the following two programs for the Fall, 1999.

===================( 1. SEMINAR )====================

Title: The Discovery of Multiple, Interacting Genes
Speaker: S. Stanley Young, Glaxo Wellcome Inc.

Date: Friday, October 1, 1999
Time: 3:30 - 5:00 PM

Location: R.W. Johnson Pharmaceutical Research Institute
Ortho-McNeil Pharmaceutical Auditorium
1000 Route 202 South
Raritan, NJ 08869
(908) 218-7297 (Jim Colaianne)

Register: All attendees must register in advance in order to
attend this seminar. Please contact either
Jim Colaianne at jcol...@prius.jnj.com or
Al Barron at aba...@prius.jnj.com for
registration.

A reception with refreshments will be held at 3 PM.

Abstract:

Many of the disease traits of individuals are likely to be under
the control of multiple, interacting genes. With the advent of
DNA chips, large numbers of genetic markers, and large scale
experiments, data will become available for the discovery of
multiple gene effects. While we can currently identify markers
linked or associated with a single disease gene, there is no
current statistical analysis method for linking phenotype to
complex combinations of the 50,000 to 100,000 human genes
or markers, SNPs. Recursive partitioning, RP, is a statistical
technique for finding complex interactions among many variables
to explain a response. RP easily handles large numbers of
cases and mixtures; we extend RP to handle very large numbers
of variables expected in genetics data sets.

Attention is paid to algorithmic speed, computer storage, and
the multiple testing problem. We show how these methods can
be applied to establish a genotype-phenotype relationship.
The benefits of this method are many-fold, but include the
association of phenotype to multiple, possibly interacting, gene
effects.

(Stan Young is a statistician with extensive experience in the
pharmaceutical industry. He has published in Science, Biometrics,
JASA, Journal of Medicinal Chemistry, QSAR, etc. He published
Resampling-Based Multiple Testing, 1993, Wiley, NY. He is
currently interested in the application of data mining techniques
to large chemistry and genetics data sets.)

==================( 2. SHORT COURSE )==================

Title: "Regression Graphics: Ideas for Studying
Regressions Through Graphics"

Speaker: R. Dennis Cook,
University of Minnesota

Date: Friday, October 15, 1999
Time: 9:00 AM - 5:00 PM

Location: The Palmer Inn
3499 Route 1 South
Princeton, NJ 08540
(609) 452-2500 or (800)-688-0500

Register: Course cost is $75. The textbook, "Regression
Graphics: Ideas for Studying Regression Through
Graphics" is $53.

To register for this short course, please contact
either Jim Colaianne at jcol...@prius.jnj.com or
Arthur Silverberg at arthur.s...@covance.com
for registration.

Sponsorship: This short course is jointly sponsored by the
New Jersey and Princeton/Trenton Chapters, ASA.

Abstract: Refer to Dennis Cook's website for a detailed
description at http://www.stat.umn.edu/RegGraph/ .

Click on the link for "NJ Short Course".

(Dennis Cook is Professor, Dept. of Appl,
Statistics,
University of Minnesota. He is coauthor of "An
Intro-
duction to Regression Graphics" and has numerous
articles in regression, experimental design,
diagnostics, and population genetics. He received
his PhD degree in statistics from Kansas State
University and is a Fellow of the ASA and the
Institute
of Mathematical Statistics.)

Posted: September 1, 1999