[P] Signal Transduction and Cancer - Yale Medicine School
Norbert Glaser
Postdoctoral Position in Signal Transduction and Cancer
Immediately available in Department of Pathology, Yale University School of
Medicine
Successful applicants will join a very active and stimulating laboratory
currently composed of 8 postdoctoral fellow/associates, 1 graduate student
and 2 research assistants, equipped with state-of art facilities.
The applicant must have strong background in molecular biology or
immunology or cancer biology. The commitment to basic science research is
required. The applicants with the potential to obtain a fellowship
from NIH or other foundations are prefered.
Project will involve studies of signal transduction from cytokine receptors
to transcription factor STAT and their possible roles in cancer development
Background and our Research Interest:
A variety of protein ligands (such as hormones and cytokines) induce
activation of protein tyrosine kinases (PTK) and affect gene expression.
Our laboratory working on a recently established signaling pathway involving
direct activation of cytoplasmic transcription factors by tyrosine kinases. A
direct signaling model of signal transduction has been proposed (Fu, 1992).
In this model, the transcription factors (termed STAT) are directly
activated by a membrane receptor-associated tyrosine kinase(s) through their
SH2 (Src homology region 2) domains. These activated transcription factors
then translocate to the nucleus to join a nuclear protein to form an active
transcriptional complex, inducing expression of specific functional
proteins. Most recently, studies from our lab and other laboratories have
also demonstrated that Interferons, EGF, PDGF, CSF-1, IL-2, IL-3, IL-4, IL-5,
IL-6, and IL-10 etc., all use this direct pathway to control nuclear
transcriptional events (reviewed in Darnell et al., 1994). A fundamental
question in cancer research is whether and how these signaling pathways are
involved abnormal cell growth and transformation of normal cells. Our
current research is aiming to expand our understanding of the signal
transduction of cytokines, especially the functions of STAT to the field of
cancer immunology which includes STAT function in cancer development and in
the general cellular immune responses.
References:
Darnell, J. E., Kerr, I. M. and Stark, G. R. (1994) Science, 264, 1415-
1421.
Fu, X.-Y. (1992) Cell, 70 323-335.
Fu, X.-Y., Schindler, C., Improta, T., Aebersold, R.H., and Darnell, Jr.,
J.E. (1992). Proc. Natl. Acad. Sci. USA, 89, 7840-7843.
Fu, X.-Y. and Zhang, J.-J. (1993) Cell 74, 1135-1145.
Fu, X.-Y. (1995) J. Leuk. Biol, 57, 529-535.
Interested may send your c.v. and names of
three references to
Dr. Xin- Yuan Fu at "FuXi.P...@DVPO.YNHH.Yale. Edu "
Fax: 203-785-7303.
Mailing: Department of Pathology, 310 Cedar Street, Yale
University School of Medicine, New Haven CT
06520-8023
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Norbert Glaser
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http://www.loria.fr/~glaser/postdoc.html