Update 25.12 Nanotechnology milestone: a general method for designing stable proteins

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Foresight Institute

Dec 28, 2012, 1:01:51 AM12/28/12
** Nanotechnology milestone: a general method for designing stable proteins

** Foresight Update 25.12 - December 26, 2012
ISSN 1078-9731

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** The 2013 Foresight Technical Conference
Illuminating Atomic Precision
January 11-13, 2013
Crowne Plaza Cabana Hotel, Palo Alto, CA

** Nanotech News

Discuss these news stories at http://foresight.org/nanodot.

** In this issue:
* Testing and improving scaffolded DNA origami for molecular nanotechnology
* Two types of artificial muscle from nanotechnology
* Optimal bond loads in designing molecular machines
* Arbitrarily complex 3D DNA nanostructures built from DNA bricks
* New strides in understanding mechanochemical reactions
* Nanotechnology milestone: general method for designing stable proteins

** Testing and improving scaffolded DNA origami for molecular nanotechnology

Scientists at the Technische Universitat Munchen have published two
papers documenting major enhancements to scaffolded DNA origami.

** Two types of artificial muscle from nanotechnology

Biology uses various types of molecular machines to produce movement, all of
which are candidates to be mimicked for use in nanotechnology. Muscles produce
movement through the contraction of systems of polymers, powered by the release
of chemical energy. Now scientists from France's CNRS have developed an
artificial muscle that produces micrometer-scale movement through the
coordinated action of thousands of individual molecular machines each producing
nanometer-scale movement.

** Optimal bond loads in designing molecular machines

One issue in designing molecular machine systems to do nanoscale work, such as
molecular manufacturing, is how to transfer energy to implement guided
molecular motions, to move components or to make or break chemical bonds.

** Arbitrarily complex 3D DNA nanostructures built from DNA bricks

This past May we posted news of a major advance in the toolkit for DNA
nanotechnology. ... a very versatile, rapid, and inexpensive way to assemble
arbitrarily complex 150-nm two-dimensional DNA nanostructures from
42-nucleotide DNA tiles. [Now} another major advance from the same research

** New strides in understanding mechanochemical reactions

Mechanochemistry is the process of using mechanical force to effect bulk
chemical reactions with small (catalytic) amounts of solvent. Although the
process lacks any form of the positional control that is a cornerstone
capability of productive nanosystems, understanding how chemical reactions
proceed under mechanical force will help lessen the gap between current and
future machine-phase synthesis.

** Nanotechnology milestone: general method for designing stable proteins

Yet another milestone along the protein design molecular engineering path to
advanced nanotechnology has been reached, thanks to the efforts of the
laboratory of David Baker, one of the 2004 winners of the Foresight Feynman
Prize in Nanotechnology for Theoretical work.

-- Nanodot posts by James Lewis (http://www.foresight.org/about/Lewis.html) and
Stephanie C.

** Foresight Events and News

** 2012 Foresight Prize Winners Announced

The winner of the 2012 Feynman Prize for Experiment is the team of Gerhard
Meyer, Leo Gross, and Jascha Repp for their work at IBM Research in Zurich (Dr.
Repp is now at Regensburg University). The winner of the 2012 Feynman Prize for
Theory is David Soloveichik of University of California, San Francisco, for his
general theory of DNA displacement cascades.

For more information : (http://www.foresight.org/about/2012Feynman.html)

The Foresight Institute is pleased to announce that the winner of the 2012
Distinguished Student Award is David Walker, a Ph.D. student at Northwestern
University in Evanston, Illinois.

For more information : (http://www.foresight.org/about/StudentAward2012.html)

** The 2013 Foresight Technical Conference
Illuminating Atomic Precision

** January 11-13, 2013
Crowne Plaza Cabana Hotel, Palo Alto, CA USA

Conference Co-Chairs
Larry S. Millstein, President, Foresight Institute
J. Fraser Stoddart, Board of Trustees Professor, Northwestern University

Diamond Sponsor: The Thiel Foundation
Silver Sponsors: Autodesk, Zyvex Labs
Bronze Sponsor: Millen, White, Zelano & Branigan, PC

Over 30 leading researchers will present reviews and results on a wide range of
research relating to atomic and molecularly precise devices and materials, and
their fabrication. The conference will provide an unusually heterogeneous mix
of speakers and participants, serving as a catalyst for interdisciplinary
dialog and productive collaboration.

Sessions (https://www.foresight.org/conference/sessions/) include :

Atomic Scale Devices
Session Chair: John Randall, Zyvex Labs

Molecular Machines and Non-Equillibriun Processes
Session Chair: J. Fraser Stoddart, Northwestern University

Self Organizing and Adaptive Systems
Session Chair: Lee Cronin, Glasgow University

Commercially Implemented Single Molecule Technologies
Session Chair: SteveTurner, Pacific Biosciences

Computation and Molecular Nanotechnologies
Session Chair: Alex Wissner-Gross, Harvard and MIT

Additional speakers will include the Feynman Prize winners for Theory and for
Experiment for both 2011 and 2012, and the winners of the Feynman Student
Prizes for 2011 and 2012.

For the full conference schedule, detailed information on sessions, speakers
and talks, and how to register use the following links --

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** 2012 Challenge Grant

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Deadline: December 31, 2012

With contributions like yours, Foresight will be able to advance beneficial
nanotechnology through our publications, prizes, and Technology Roadmap for
Productive Nanosystems. We will continue to be a growing force enabling
businesses, scientists, technologists, policy makers, investors, and
individuals to be informed about how nanotechnology can contribute to a better

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Foresight is matched dollar-for-dollar to that amount. Donations and
memberships sent by December 31 qualify as 2012 tax deductions. For extra tax
savings, donate appreciated stock.

Read more and donate (http://www.foresight.org/challenge/)

** Foresight Youth Outreach
Summer/Fall 2012 Essay Contest & Literature Program

Foresight is targeting the top 300 science, engineering, &
entrepreneurially-oriented college clubs, high school STEM teachers, & gifted
youth programs across the country - and connecting them with great
ideas & people!

We're sending bright young minds the following books by speakers, advisors, &
supporters of the Foresight community (organizations sponsoring individual book
donations are in parentheses):

Abundance: The Future Is Better Than You Think - Peter Diamandis (XPrize
Engines of Creation - K Eric Drexler (Foresight Institute)
Imagine Design Create - Tom Wujec (AutoDesk)
The Singularity Is Near - Ray Kurzweil (KurzweilAI, SingularityU)
Ending Aging - Aubrey deGrey (SENS Foundation)
100+ - Sonia Arrison (Thiel Foundation)
Global Catastrophic Risks - Nick Bostrom (FHI, Singularity Institute)
NanoScience Education, WorkForce Training, and K12 Resources - Miguel
Aznar/Judith Lightfeather (Foresight - for STEM HS)

We're also planning an inspiring Essay Contest that incentivizes students to
read, reflect, & connect with our communities! Supporting sister organizations
such as Space Frontier Foundation, Humanity+, SENS, and 20Under20+ are also
putting promotional material in book-boxes.

We need your help to make this pilot a success.
Most books came in as physical donations, but this is a bootstrapped project;
we're still seeking funds to support the financial incentive prizes, student
conference tickets, & remaining books being shipped in this week. If you'd like
to help maximize this project's leverage, please contribute!

Teachers or student orgs interested in the outreach program can sign up to have
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For more information, contact foresightATforesight.org

** Other Upcoming Activities of Interest

A future issue of Update will report on the FNANO conference held this Spring
at Snowbird.

** Nanotech Conference & Expo 2013

May 12-16, 2013
Washington, DC USA

Don't miss this year in Washington, D.C. as we deliver the World's top
innovations and the Nation's leading R&D agency programs!

** About the Foresight Institute
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Jan 26, 2013, 1:43:47 AM1/26/13


I think that we could try to define the amino acid of the nanotechnologies
with collaborative contributions considering molecules as well as the
nanotechnologies drug discovery
Before analyzing molecules , you should also try:


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