Commercially Implemented Single Molecule Technologies: Session Spotlight 4

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Foresight Technical Conference

Dec 28, 2012, 12:41:34 AM12/28/12
$150 off conference registration: code 2013QCDR

Learn about cutting edge nanotechnology research!
Foresight Institute (
2013 Foresight Technical Conference:
Illuminating Atomic Precision - January 11-13, 2013
The Crowne Plaza Hotel, Palo Alto, CA, USA
Commercially Implemented Single Molecule Technologies: Session Spotlight 4

During the afternoon session of Sunday January 13th, the third day of the
conference ( , we'll focus on
nanotechnologies that are currently being implemented commercially. Recent
advances in real time observation of single molecules have fueled a series of
breakthroughs in our understanding of the inner workings of real life processes.

This session will be chaired by Steve Turner
( , founder
and CTO of Pacific Biosciences. Dr. Turner is a co-inventor of single molecule
real time (SMRT) DNA sequencing, which uses a zero-mode waveguide (ZMW) to
observe single nucleotides in real time as they're being incorporated by DNA
polymerase. We'll cover the development of the ZMW and survey applications it
has enabled, spanning several different topics in single molecule biophysics.

We'll continue with an investigation of another recently developed method for
observing individual molecules: nanopore detectors. Mark Akes on
( , Professor of Biomolecular
Engineering at U.C. Santa Cruz, will explain how he and his colleagues have
been using the detectors to understand the structure and dynamics of DNA duplex
ends, including those of retrotransposons and HIV. Nanopores can also be used
to single out individual molecules for manipulation or modification; we'll
learn about Dr. Akeson's techniques for enzymatic control of single DNA strands
using nanopores.

Our next presenter, George Church
( , Professor of Genetics
and Harvard Medical School and director of, will discuss a
variety of commercially implemented technologies involving gene sequencing and
synthesis, including molecular multiplexing, barcoding, and automation.

The session will conclude with a presentation from Joseph Puglisi
( , Director of the
Stanford Magnetic Resonance Laboratory, who has pioneered the use of nuclear
magnetic resonance (NMR) in the study of RNAs and RNA-ligand complexes. His
early work showed how small molecules can bind to RNAs, which has led to the
field of RNA as a drug target, and inspired new questions about the role
of RNA in cellular processes and disease. In his presentation, Dr. Puglisi
will review a body of work on translation, showing the process for the first
time at the single-codon level in real time.

The conference is a little over two weeks away! Don't miss out. Register now!
* There are limited conference scholarships available. If you know a student
who is interested in learning about nanotechnologies, email ( for details.
* If you would like information about special room rates at Crowne Plaza
Hotel, email ( .


Use registration code 2013QCDR for a $150 discount.

The conference has a unique focus on molecularly and atomically precise
research and technology in five specific areas: Atomic Scale Devices,
Molecular Machines, Self Assembling and Self-Adaptive Systems, Commercial Scale
Devices and Computation and Modeling. More than thirty leading researchers from
around the world will present reviews and results on a wide range of work
relating to atomically and molecularly precise processes, materials, and
devices. The wide variety of topics will stimulate interdisciplinary dialog,
productive collaboration, and scientific and technical progress towards
beneficial nanotechnologies.

A truly remarkable schedule of outstanding research leaders from all over the
world will be presenting their latest results and outlooks. And, in addition to
the sessions, the conference includes a Friday night reception for all
participants and networking luncheons on Saturday and Sunday.

The Foresight Feynman Awards Banquet will be held at the conference on Saturday
night. The 2011 and 2012 awards for Theory and Experiment, and the 2012 Student
Award will all be presented at the Banquet. (Separate registration required.
The event invariably sells out. Register early.)

It has been 26 years since Foresight was founded: long before the invention of
scanning tunneling and atomic force microscopes, the discovery of
Buckminsterfullerene, carbon nanotubes, and graphene, the development of
quantum dots, semi-conducter manufacturing processes below the visible light
diffraction limit, nanometer scale integrated circuit features, single atom
gated transistor devices, quantum computers, mechanical bonds and molecular
machines, mechanochemistry, DNA origamis and RNA walkers, self-assembled
molecularly perfect monolayers, modular self-assembling chemical systems, and a
wide variety of other nanoscale and atomic and molecular technologies. These
developments in one way or another have brought us closer to one of Foresight's
core goals: the realization of atomically and molecularly precise processes,
materials, and devices. But a lot of work remains to be done to realize the
benefits of applying such technologies productively to real world problems on
the macro scale.

This conference aims to spur progress in doing just that. We hope to see you

Copyright (C) 2012 Foresight Instiitute, All rights reserved.

Our mailing address is:
PO Box 61058, Palo Alto, CA 94306 USA
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