Iron Induces Death
ironjustice
"Iron dextran is easy, safe"
Medscape Alerts
"Fatal reactions have followed the test dose of iron dextran"
Safety and Efficacy of Total-Dose Infusion of Low Molecular Weight
Iron
Dextran for Iron Deficiency Anemia in Patients with Inflammatory Bowel
Disease.
Koutroubakis IE, Oustamanolakis P, Karakoidas C, Mantzaris GJ,
Kouroumalis EA.
Department of Gastroenterology, University Hospital Heraklion, P.O.
Box 1352, 71110,
Heraklion, Crete, Greece, ikou...@med.uoc.gr.
BACKGROUND:
Intravenous iron has been suggested as a safe and effective treatment
of anemia
complicating inflammatory bowel disease (IBD).
Low molecular weight (LMW) iron dextran has the ability to administer
the
patient's total iron requirement in a single infusion.
AIMS:
The aim of this study was to assess the safety and efficacy of the
total dose of
LMW iron dextran infusion for the treatment of iron deficiency in
IBD.
METHODS:
Fifty IBD patients (27 female, 35 Crohn's disease, 15 ulcerative
colitis) were included
in the study.
Mean +/- standard deviation (SD) hemoglobin and ferritin levels before
the infusion
were 9.88 +/- 1.42 g/dl and 13.9 +/- 10.9 ng/ml, respectively.
A 25-mg test dose was followed by infusion of the total dose of LMW
iron dextran
based on the iron deficit.
Several clinical and laboratory parameters were measured before and on
week 4
after infusion.
RESULTS:
Four patients (8%) developed adverse reactions during the test
infusion and did not
receive the total-dose infusion.
Only one patient developed an allergic reaction during the total-dose
infusion.
In the remaining 45 patients, the mean +/- SD iron dose that was given
was
1,075 +/- 269 mg.
The mean +/- SD elevation of hematocrit and hemoglobin on week 4 was
4.9 +/- 1.9% and 1.7 +/- 0.8 g/dl, respectively.
Hematopoietic response was observed in 23 of 45 patients (51.1%).
CONCLUSION:
Total parenteral iron replacement with LMW iron dextran is an easy,
safe, and
effective alternative method for treating iron deficiency anemia in
IBD.
Harmless adverse reactions may develop in a minority of patients.
PMID: 19834803
---------------
From Medscape Medical News
Medscape Alerts
Test Dose, Observation Recommended for Iron Dextran Administration
Deborah Flapan
http://www.medscape.com/viewarticle/710711
Published: 10/16/2009
October 16, 2009 — Anaphylactic reactions, including fatalities, have
been reported after parenteral administration of iron dextran
injection (Dexferrum), the US Food and Drug Administration (FDA) and
American Regent announced today. Administration of a test dose before
the first therapeutic dose and close observation of patients for
anaphylactic reactions during administration are strongly recommended.
The boxed warning for iron dextran has been revised to include this
information, according to an alert from MedWatch, the FDA's safety
information and adverse event reporting program.
"Fatal reactions have followed the test dose of iron dextran
injection, even in situations where the test dose was tolerated," the
FDA notes. "Patients with a history of drug allergy or multiple drug
allergies may be at increased risk of anaphylactic-type reactions."
During iron dextran administration, the FDA recommends that
resuscitation equipment and personnel trained in the detection and
treatment of anaphylactic-type reactions be readily available.
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Who loves ya.
Tom
Jesus Was A Vegetarian!
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DEAD PEOPLE WALKING
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Kofi
<5febc231-dc95-41a0...@y10g2000prg.googlegroups.com>,
ironjustice <teamt...@hotmail.com> wrote:
> Who to believe ..
>
> "Iron dextran is easy, safe"
> Medscape Alerts
> "Fatal reactions have followed the test dose of iron dextran"
>
> Safety and Efficacy of Total-Dose Infusion of Low Molecular Weight
> Iron
> Dextran for Iron Deficiency Anemia in Patients with Inflammatory Bowel
> Disease.
If these people would bother to actually read, they'd know iron
suppresses cathelicidin production which is already low in the IBD gut.