Iron Chelator In Stroke

[ironjustice]

Deferoxamine Treatment for Intracerebral Hemorrhage in
Aged Rats. Therapeutic Time Window and Optimal Duration.
Stroke. 2009 Dec 31.
Okauchi M, Hua Y, Keep RF, Morgenstern LB, Schallert T, Xi G.
From Department of Neurosurgery and the Stroke Program,
University of Michigan, Ann Arbor, Mich; Department of Psychology,
University of Texas at Austin, Austin, Tex.

BACKGROUND AND PURPOSE: Deferoxamine (DFX) reduces brain edema,
neurological deficits, and brain atrophy after intracerebral
hemorrhage (ICH) in aged and young rats.
Our previous study found that 50 mg/kg is an effective dose in
aged rats.
In the present study, we explored potential therapeutic time
windows and optimal therapeutic durations.
METHODS:
Aged male Fischer 344 rats (18 months old) sustained an intracaudate
injection of 100 muL autologous whole blood, followed by
intramuscular
DFX or vehicle beginning at different time points, or continuing for
different durations.
Subgroups of rats were euthanized at day 3 for brain edema
measurement
and day 56 for brain atrophy determination.
Behavioral tests were performed on days 1, 28, and 56 after ICH.
RESULTS:
Systemic administration of DFX, when begun within 12 hours after ICH,
reduced brain edema.
DFX treatment started 2 hours after ICH and administered for >/=7
days
attenuated ICH-induced ventricle enlargement, caudate atrophy, and
neurological deficits.
DFX attenuated ICH-induced brain atrophy and neurological deficits
without detectable side effects when begun within 24 hours and
administered for 7 days.
CONCLUSIONS:
To the extent that these results can be translated to humans, the
therapeutic time window and the optimal duration for DFX in this aged
rat model of ICH may provide useful information for an ongoing DFX-
ICH
clinical trial.

PMID: 20044521

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Tom

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[fer...@paris.com]

Posting this abstract is a good example of a common faulty logic on the
part of the poster .

It is presumed that because some substance has some action ralative to
iron shown in other studies that the
disorder it is being applied to is because of the iron action in those
studies . All this despite the complete lack of mentioning iron in the
abstract.

Aspirin has the same iron activity, would the same outcome happen? The
logic we are being forced fed would say it must.

[ironjustice]

On Jan 5, 3:53 pm, ferr...@paris.com wrote: snip <<

You are a fkg retard ..

NEW .. rule ..

NO .. fkg .. retards ..

Therefore ..

You are a left-handed atheist retard ..

Threee .. strikes ..

[Ken]

The Spamming Canuck Cocksucker

[fer...@paris.com]

The response:

"You are a fkg retard .."

Then because we run circles around you in spotting some very basic flaws
of logic and errors of fact , what does that make you?

[ironjustice]

NO .. fkg .. retards ..

NO .. fkg .. shteaters ..

NO .. fkg .. atheists ..

You all smell of sht ..

Retards can be forgiven .. FOR .. smelling of sht ..

Sooooo once again .. shteater ..

Threeeee .. fkg .. strikes ..

Giiiiit .. you fkg .. shteating retarded atheist ..

Sorta redundant .. but .. hey .. nobody said you were .. special ..