Vitamin d or a walk in the sun a powerful weapon against diabetes? Or is your dermatologist making it more likely that diabetics have heart attacks?
vince
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=6244408
Vitamin D supplementation reduces insulin resistance in South Asian
women living in New Zealand who are insulin resistant and vitamin D
deficient – a randomised, placebo-controlled trial
Pamela R. von Hursta1 c1, Welma Stonehousea1 and Jane Coada2
a1 Institute of Food, Nutrition and Human Health, Massey University,
Private Bag 102 904, North Shore Mail Centre, Auckland, New Zealand
a2 Institute of Food, Nutrition and Human Health, Massey University,
Palmerston North, New Zealand
Abstract
Low serum 25-hydroxyvitamin D (25(OH)D) has been shown to correlate
with increased risk of type 2 diabetes. Small, observational studies
suggest an action for vitamin D in improving insulin sensitivity and/
or insulin secretion. The objective of the present study was to
investigate the effect of improved vitamin D status on insulin
resistance (IR), utilising randomised, controlled, double-blind
intervention administering 100 μg (4000 IU) vitamin D3 (n 42) or
placebo (n 39) daily for 6 months to South Asian women, aged 23–68
years, living in Auckland, New Zealand. Subjects were insulin
resistant – homeostasis model assessment 1 (HOMA1)>1·93 and had serum
25(OH)D concentration < 50 nmol/l. Exclusion criteria included
diabetes medication and vitamin D supplementation >25 μg (1000 IU)/d.
The HOMA2 computer model was used to calculate outcomes. Median (25th,
75th percentiles) serum 25(OH)D3 increased significantly from 21 (11,
40) to 75 (55, 84) nmol/l with supplementation. Significant
improvements were seen in insulin sensitivity and IR (P = 0·003 and
0·02, respectively), and fasting insulin decreased (P = 0·02) with
supplementation compared with placebo. There was no change in C-
peptide with supplementation. IR was most improved when endpoint serum
25(OH)D reached ≥ 80 nmol/l. Secondary outcome variables (lipid
profile and high sensitivity C-reactive protein) were not affected by
supplementation. In conclusion, improving vitamin D status in insulin
resistant women resulted in improved IR and sensitivity, but no change
in insulin secretion. Optimal vitamin D concentrations for reducing IR
were shown to be 80–119 nmol/l, providing further evidence for an
increase in the recommended adequate levels.
And http://mednews.wustl.edu/news/page/normal/14489.html
Research shows why low vitamin D raises heart disease risks in
diabetics
By Jim Dryden
Aug. 21, 2009 -- Low levels of vitamin D are known to nearly double
the risk of cardiovascular disease in patients with diabetes, and
researchers at Washington University School of Medicine in St. Louis
now think they know why.
They have found that diabetics deficient in vitamin D can't process
cholesterol normally, so it builds up in their blood vessels,
increasing the risk of heart attack and stroke. The new research has
identified a mechanism linking low vitamin D levels to heart disease
risk and may lead to ways to fix the problem, simply by increasing
levels of vitamin D
"Vitamin D inhibits the uptake of cholesterol by cells called
macrophages," says principal investigator Carlos Bernal-Mizrachi,
M.D., a Washington University endocrinologist at Barnes-Jewish
Hospital. "When people are deficient in vitamin D, the macrophage
cells eat more cholesterol, and they can't get rid of it. The
macrophages get clogged with cholesterol and become what scientists
call foam cells, which are one of the earliest markers of
atherosclerosis."............
Andrew B. Chung, MD/PhD
>
>http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=6244408
>
> Vitamin D supplementation reduces insulin resistance in South Asian
>women living in New Zealand who are insulin resistant and vitamin D
>deficient � a randomised, placebo-controlled trial
>Pamela R. von Hursta1 c1, Welma Stonehousea1 and Jane Coada2
>a1 Institute of Food, Nutrition and Human Health, Massey University,
>Private Bag 102 904, North Shore Mail Centre, Auckland, New Zealand
>a2 Institute of Food, Nutrition and Human Health, Massey University,
>Palmerston North, New Zealand
>
> Abstract
>
>Low serum 25-hydroxyvitamin D (25(OH)D) has been shown to correlate
>with increased risk of type 2 diabetes. Small, observational studies
>suggest an action for vitamin D in improving insulin sensitivity and/
>or insulin secretion. The objective of the present study was to
>investigate the effect of improved vitamin D status on insulin
>resistance (IR), utilising randomised, controlled, double-blind
>intervention administering 100 ?g (4000 IU) vitamin D3 (n 42) or
>placebo (n 39) daily for 6 months to South Asian women, aged 23�68
>years, living in Auckland, New Zealand. Subjects were insulin
>resistant � homeostasis model assessment 1 (HOMA1)>1�93 and had serum
>25(OH)D concentration < 50 nmol/l. Exclusion criteria included
>diabetes medication and vitamin D supplementation >25 ?g (1000 IU)/d.
>The HOMA2 computer model was used to calculate outcomes. Median (25th,
>75th percentiles) serum 25(OH)D3 increased significantly from 21 (11,
>40) to 75 (55, 84) nmol/l with supplementation. Significant
>improvements were seen in insulin sensitivity and IR (P = 0�003 and
>0�02, respectively), and fasting insulin decreased (P = 0�02) with
>supplementation compared with placebo. There was no change in C-
>peptide with supplementation. IR was most improved when endpoint serum
>25(OH)D reached ? 80 nmol/l. Secondary outcome variables (lipid
Laus Deo for His moving you to post this :-)
May dear neighbors, friends, and brethren have a blessedly wonderful
life in remembrance of the birth of our LORD Jesus Christ as our
Messiah, the Son of Man:
Be hungrier, which truly is healthier for the heart, soul, and mind:
http://groups.google.com/group/sci.med.cardiology/msg/f882137d4e2858d8?
Marana tha
Prayerfully in the awesome name of our Messiah, LORD Jesus Christ,
Andrew <><
--
Andrew B. Chung, MD/PhD
Board-certified Cardiologist
and Author of "Be Hungry"
http://NetCabal.com
"Don't be left behind as were Cleopas and Simon ...
... -----------------> be hungry ! ! !"
"... no one can say 'Jesus is LORD' except by the Holy Spirit." (1 Cor
12:3)
http://groups.google.com/group/sci.med.cardiology/msg/035c93540862751c?
What are the keys of the Kingdom of Heaven?
http://groups.google.com/group/sci.med.cardiology/msg/980b41e6999de315?
Only the truth can cure the "hunger is starvation" delusion:
http://groups.google.com/group/sci.med.cardiology/msg/74281ab7d7ce78de?
Happy Oyster
wrote:
>Be hungrier, which truly is healthier for the heart, soul, and mind:
>http://groups.google.com/group/sci.med.cardiology/msg/f882137d4e2858d8?
Go to Ehiopia and try to tell your bloody lies there.
The hungry will nail you to the wall...
.
--
Die volle H�rte: http://www.kindersprechstunde.at
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Die Medienmafia � Die Regividerm-Verschw�rung
http://www.transgallaxys.com/~kanzlerzwo/showtopic.php?threadid=5710
