Leukemia IS .. Polycythemia
ironjustice
Leukemia
Jan 5 11:55 AM US/Eastern
TEL AVIV, Israel, Jan. 5 /PRNewswire/ -- A team of Israeli scientists
at the Sheba Medical Center's Research Center for Leukemia and
Childhood Malignancies has discovered a method for developing a more
effective and less perilous treatment for those suffering from
childhood leukemia, the most common cancer in children. New treatments
associated with the research have the potential to impact upwards of
20 percent of those suffering from Acute Lymphoblastic Leukemia (ALL).
The team, led by Dr. Shai Izraeli, who worked in partnership with
scientists at Tel Aviv University and the International BFM Study
Group, has published a series of papers examining certain gene
abnormalities in children with Down syndrome, which are 20-30 times
more likely to develop ALL.
"Our research gives hope to a substantial portion of the children who
might be taken by this horrible disease," Izraeli said.
In the most recent paper, published in the leading hematology journal
Blood, the researchers found that a gene abnormality called CLRF2 is
common in more than 60% of ALL patients with Down syndrome. What makes
this finding so significant is that the abnormality is directly
connected to an anomalous protein, JAK2, which stimulates the kind of
disruptive cell behavior typical of leukemia. Importantly, these
abnormalities, which have now also been examined and reported by
several research groups in the US and Europe, also appear in the
leukemia cells of some children and adults without Down syndrome as
well.
The findings indicate that using drugs to block the activity of
anomalous JAK2 can effectively treat blood cells transformed by the
abnormality. This targeted approach is likely to be more precise and
less toxic than chemotherapy.
Currently, children with leukemia, receive intensive chemotherapy over
two to three years, and about eight out of 10 recover. But
chemotherapy is highly toxic, and does not target the specific
abnormality underlying the disease. Treatments associated with this
research would be able to address these issues, and importantly the
drugs already exist.
Drugs targeting the JAK2 protein are currently in clinical trials –
but for a different blood disorder (polycythemia vera). Thus, if
preclinical and then clinical trials in those suffering from ALL
confirm Izraeli's findings, no new drug need be developed – often a
task that can take more than a decade to complete.
Using these existing drugs as a basis, Izraeli and his team are
confident that more powerful and safer leukemia drugs for children are
only a few years away. "We will know in just a few years specifically
what these drugs are capable of, but the research conducted thus far
gives me great hope," Izraeli said.
"The breakthroughs we've achieved were made possible by the advantages
of our location within the Sheba Medical Center; specifically its
proximity to the patients and to the most advanced state-of-the-art
research infrastructure which together allow us to quickly translate
questions arising from observations in patients to laboratory
research," Izraeli said.
The Sheba Medical Center, with 1900 beds, is the largest and most
comprehensive tertiary medical center in the Middle East, affiliated
with the Sackler Faculty of Medicine at Tel Aviv University. The
Medical Center is the largest university-affiliated hospital in Israel
and is known for excellence in basic and applicable research. Patients
from all over the world, including the US, Europe and the Palestinian
Territories are treated at this facility.
SOURCE Sheba Medical Center
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Tom
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corre...@dude.com
ironjustice
Nope, nothing in the article supports this conclusion. <<
Actually .. dckhd ..
They targeted the polycythemia and cured the cancer ..
THAT means .. leukemia IS polycythemia ..
Right it down and remember .. I .. told you that long before .. now ..
Sooooo .. fkff ..
ironjustice
polycythemia vera <<
Bloodletting .. whoda .. thunk ..
http://www.nhlbi.nih.gov/health/dci/Diseases/poly/poly_treatments.html
Goals of Treatment
The goals of treating PV are to control symptoms and reduce the risk
of complications, especially heart attack and stroke. To do this, PV
treatments reduce the number of red blood cells and the level of
hemoglobin (an iron-rich protein) in your blood. This brings the
thickness of your blood closer to normal.
Treatments To Lower Red Blood Cell Levels
Phlebotomy
Phlebotomy (fle-BOT-o-me) is a procedure that removes some blood from
your body. A needle is inserted into your vein, and your blood flows
through an airtight tube into a sterile container or bag. The process
is similar to the process of donating blood.
Phlebotomy reduces the number of red blood cells in your system and
starts to bring your blood thickness closer to normal. Typically, a
pint (1 unit) of blood is removed each week until your hematocrit
level approaches normal. (Hematocrit is the measure of how much space
red blood cells take up in your blood.)
You may need to have phlebotomy done every few months.
ironjustice
polycythemia vera <<
Iron chelators .. whoda .. thunk ..
"Iron chelator hydroxyurea"
http://www.nhlbi.nih.gov/health/dci/Diseases/poly/poly_treatments.html
Medicines
Your doctor may prescribe medicines, such as hydroxyurea or interferon-
alpha, to keep your bone marrow from making too many red blood cells.
Hydroxyurea is a medicine generally used to treat cancer. This
medicine can reduce the number of red blood cells and platelets in
your blood. As a result, this medicine helps improve your blood flow
and bring the thickness of your blood closer to normal.
--------------
Iron chelators hydroxyurea and bathophenanthroline
disulfonate inhibit DNA synthesis by different pathways.
Biochemistry and molecular biology international
1994;34(2):273-9.
1994: Alcaín F J; Löw H; Crane F L; Navas P
We previously showed that thrombin-stimulated DNA synthesis
in CCL 39 cells was inhibited by hydroxyurea (HU) and
bathophenanthroline disulfonate (BPS)
(Proc. Natl. Acad. Sci. USA, in press).
A clear difference exists between these two inhibitors.
Inhibition mediated by HU was immediate and must be present
in the culture medium.
BPS was equally effective when it was present in the medium
or after preincubation, but it required at least 12 h to
achieve maximal effect.
The permeable form 1,10 phenanthroline had the same inhibitory
effect in short-term incubations that BPS.
Moreover, 1,10 phenanthroline was cytotoxic in long-term
incubations indicating that the site of BPS inhibition was
outside the cell.
Further, long-term incubations with HU did not affect the
ability of the cell to reinitiate DNA synthesis after removal
of the chelator.
Who loves ya.
Tom
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk- Hide quoted text -
>
> - Show quoted text -
ironjustice
polycythemia vera <<
"Radioactive phosphorus"
Whoever came up with that one ..
"Hydroxyurea"
Acute lymphoid leukemia following polycythemia vera.
Camós M, Cervantes F, Montoto S, Hernández-Boluda JC,
Villamor N, Montserrat E
Leuk Lymphoma 1999 Jan; 32(3-4):395-8.
The tendency to evolve into acute leukemia is a well-known
characteristic of polycythemia vera (PV), which is shared
with the remaining chronic myeloproliferative disorders and
increases after the administration of cytotoxic agents.
Acute transformation is usually of myeloid phenotype, whereas
acute lymphoid leukemia (ALL) following PV is seldom observed.
A 63-year-old woman is described who developed ALL at 6 years
from the initial diagnosis of PV, for which she had received
radioactive phosphorus and hydroxyurea.
The ALL was of B-cell type, corresponding to the L-3 subtype
of the FAB classification.
Despite the administration of combination chemotherapy the
patient died shortly after the diagnosis of acute leukemia.
The present case adds to seven previously described patients
with the above association, all of whom had received cytotoxic
therapy for PV.
Median interval from PV to ALL diagnosis was 10 years, and
there was a predominance of the B-cell phenotype.
The prognosis was poor since all but one of the patients had
a short survival after ALL diagnosis.
The possible etiological and pathogenetic link between PV
and the subsequent ALL is discussed.
------
Who loves ya.
Tom
corre...@dude.com
So, by your own example the two are not the same nor even the cause of
each other?
"Bloodletting .. whoda .. thunk .."
Not connected to the cancer in the article.
This is an example where a drug can be used for one condition and is
bing considered for another. You mistakenly then make the conclusion
that it is for the same thing named differently. Very sloppy, I'm sorry
to say.
Aspirin can help pain and thin blood. Is pain and thinness of blood the
same thing?
ironjustice
SOURCE Sheba Medical Center
------
"Iron chelator hydroxyurea"
http://www.nhlbi.nih.gov/health/dci/Diseases/poly/poly_treatments.html
--------------
-------------
"Radioactive phosphorus"
"Hydroxyurea"
Acute lymphoid leukemia following polycythemia vera.
------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
>
corre...@dude.com
So, by your own example the two are not the same nor even the cause of
each other?
"Bloodletting .. whoda .. thunk .."
ironjustice
snip <<
It seems you are well versed at ignoring .. fkff ..
SOURCE Sheba Medical Center
------
"Iron chelator hydroxyurea"
http://www.nhlbi.nih.gov/health/dci/Diseases/poly/poly_treatments.html
--------------
-------------
"Radioactive phosphorus"
"Hydroxyurea"
Acute lymphoid leukemia following polycythemia vera.
ironjustice
So, by your own example the two are not the same nor even the cause of
each other? <<
The red blood cells get higher and higher and higher / polycythemia
UNTIL you get way too many red blood cells / leukemia ..
Hence .. "Bloodletting .. whoda .. thunk .."
You see how that works .. do ya ..
On Jan 7, 6:11 am, correct...@dude.com wrote: Not connected to the
cancer in the article.<<
Yes it is ..
They have shown forms OF down's syndrome seem to be involved in the
Jak2 mutation which coincidentally also cause LEUKEMIA AND
POLYCYTHEMIA ..
Now in case you don't know ..
Polycythemia is ACCEPTED AS A PRECURSER to .. ? .. leukemia ..
"Drugs targeting the JAK2 protein are currently in clinical trials –
but for a different blood disorder (polycythemia vera)."
THAT means the **accepted method of control** of polycythemia vera
SINCE THE BEGINNING OF .. TIME ITSELF ..... **bloodletting** is being
CIRCUMVENTED BY DRUGS .. these JAK2 drugs ..
They 'just so happen' to work in both .. YOU say ..
Yep ..
Radioactive phosphorous .. as opposed to bloodletting ..
Hydroxyurea as opposed to bloodletting ..
JAK2 .. as opposed to .. ?
YOU say it is .. coincidence .. "This is an example where a drug can
be used for one condition and is
bing considered for another. You mistakenly then make the conclusion
that it is for the same thing named differently. Very sloppy, I'm
sorry to say."
It is .. predicted .. has been .. predicted ..
Wants to bet one of the iron chelators will work as well .. ?
I'll give you ten to one ..
I win ..
http://www.ncbi.nlm.nih.gov/pubmed/18787531
"Iron chelators inhibit Jak-STAT signaling."
The article says 'they' WANT to .. ? .. "find drugs" ..
"The findings indicate that using drugs to block the activity of
anomalous JAK2 can effectively treat blood cells transformed by the
abnormality."
Human model of polycythemia / Jak2 induces .. ? .. Downs and
leukemia ..
SOURCE Sheba Medical Center
------
"Iron chelator hydroxyurea"
http://www.nhlbi.nih.gov/health/dci/Diseases/poly/poly_treatments.html
--------------
-------------
"Radioactive phosphorus"
"Hydroxyurea"
Acute lymphoid leukemia following polycythemia vera.
corre...@dude.com
So, by your own example the two are not the same nor even the cause of
each other? <<
The response:
"The red blood cells get higher and higher and higher / polycythemia
UNTIL you get way too many red blood cells / leukemia .."
What brand of magic wand do you use in making up these "just so"
stories?
Let us have a go at helping you:
Leukemia (British/Canadian English: leukaemia) (Greek leukos
leuko'*s,
"white"; aima ai'a "blood") is a cancer of the blood or bone marrow
and is characterized by an abnormal proliferation (production by
multiplication) of blood cells, usually white blood cells
ironjustice
(production by
multiplication) of blood cells <<
You can't seem to understand simple sht ..
A red blood cell IS a .. ? .. blood cell ..
Let me repeat that for ya ..
A red blood cell is a blood cell ..
Write that down ..
Write that down .. NOW ..
AND .. ? .. fkff ..
SOURCE Sheba Medical Center
------
"Iron chelator hydroxyurea"
http://www.nhlbi.nih.gov/health/dci/Diseases/poly/poly_treatments.html
--------------
-------------
"Radioactive phosphorus"
"Hydroxyurea"
Acute lymphoid leukemia following polycythemia vera.
------
Who loves ya.
Tom
> "Acute lymphoid leukemia following polycythemia vera."
corre...@dude.com
cells could be valid shows you have a problem. It shows a clear level
of desperation and obsession not supported by just understanding what
the disorder is. And it ain't what you are claiming.
Leukemia (British/Canadian English: leukaemia) (Greek leukos
ironjustice
corre...@dude.com
Let me repeat that for ya .."
A red blood cell is a blood cell ..
Sure, but the disorder in question is about the white cell:
Leukemia (British/Canadian English: leukaemia) (Greek leukos
leuko'*s,
ironjustice
usually white blood cells <<
Why don't you show me a leukemia which isn't accompanied by ..
anemia ..
You see the word .. leukemia is derived originally from the
Sumerian phrase anemia ..
You see how that works do ya ..
ironjustice
leukemia is derived originally from the
Sumerian phrase anemia .. <<
Which .. coincidentally .. ALSO .. mentions bloodletting ..
The anemia is leukemia is UNRECOGNIZED iron **sufficiency** and
this iron **sufficiency** when TREATED .. IE: hydroxyurea or
bloodletting
.. **cures** .. the leukemia / remission of disease ..
Soooo .. one can ARGUE WHY AND HOW AND JEEZ IT CAN'T .. but .. when
push
comes to shove the simple targeting of iron .. seems .. to cure the
disease ..
------
Who loves ya.
Tom
Ken
corre...@dude.com
Sumerian phrase anemia .. <<
Which .. coincidentally .. ALSO .. mentions bloodletting ..
The anemia is leukemia is UNRECOGNIZED iron **sufficiency** and"
Nope, here are the relevant root words of the disorder and this iron
thing is false:
Anemia (pronounced /@|ni:mi@/, also spelled anaemia or anma; from
Ancient Greek anaiia anaimia, meaning "lack of blood") is a decrease
in normal number of red blood cells (RBCs) or less than the normal
quantity of hemoglobin in the blood.^[1]^[2] However, it can include
decreased oxygen-binding ability of each hemoglobin molecule due to
deformity or lack in numerical development as in some other types of
hemoglobin deficiency.