Radioactive Atherosclerotic Human Model
ironjustice
Published on Saturday, October 31, 2009
by Healthy News Service
Low-dose radiation from medical and dental x-rays could cause heart
disease, a new study suggests.
Researchers from Imperial College London say they started researching
a possible connection after numerous studies had shown that workers
exposed to long-term doses of radiation, such as in the nuclear
industry, had far higher levels of heart disease.
From this, the research team have drawn a mathematical model to
suggest
that people who have medical and dental x-rays could face similar
risks.
Radiation kills monocytes, which mop up a protein called MCP-1.
High levels of the protein are thought to cause inflammation that, in
turn,
triggers cardiovascular disease.
Research team leader Dr Mark Little says the model suggests that risks
from
x-rays may have been “substantially underestimated”.
(Source: PLOS Computational Biology, 2009; 5: e1000539).
----------------
http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1000539
A Model of Cardiovascular Disease Giving a Plausible Mechanism
for the Effect of Fractionated Low-Dose Ionizing Radiation Exposure
Atherosclerosis is the main cause of coronary heart disease and
stroke,
the two major causes of death in developed society.
There is emerging evidence of excess risk of cardiovascular disease
in various occupationally exposed groups, exposed to fractionated
radiation doses with small doses/fraction.
The mechanisms for such effects of fractionated low-dose radiation
exposures on cardiovascular disease are unclear.
We outline a spatial reaction-diffusion model for early stage
atherosclerotic lesion formation and perform a stability analysis,
based on experimentally derived parameters.
We show that following multiple small radiation doses the
chemo-attractant (MCP-1) concentration increases proportionally to
cumulative dose; this is driven by radiation-induced monocyte death.
This will result in risk of atherosclerosis increasing approximately
linearly with cumulative dose. This proposed mechanism would be
testable.
If true, it also has substantive implications for radiological
protection, which at present does not take cardiovascular disease
into account.
The major uncertainty in assessing low-dose risk of cardiovascular
disease is the shape of the dose response relationship, which is
unclear in high dose data.
Our analysis suggests that linear extrapolation would be appropriate.
Mark P. Little*, Anna Gola, Ioanna Tzoulaki
Department of Epidemiology and Public Health, Faculty of Medicine,
Imperial College London, London, United Kingdom
-----
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
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DEAD PEOPLE WALKING
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MoSn
ironjustice
Published on Saturday, October 31, 2009
by Healthy News Service
Low-dose radiation from medical and dental x-rays could cause heart
disease, a new study suggests.
Researchers from Imperial College London say they started researching
a possible connection after numerous studies had shown that workers
exposed to long-term doses of radiation, such as in the nuclear
industry, had far higher levels of heart disease.
From this, the research team have drawn a mathematical model to
suggest
that people who have medical and dental x-rays could face similar
risks.
Radiation kills monocytes, which mop up a protein called MCP-1.
High levels of the protein are thought to cause inflammation that, in
turn,
triggers cardiovascular disease.
Research team leader Dr Mark Little says the model suggests that
risks
from
x-rays may have been “substantially underestimated”.
(Source: PLOS Computational Biology, 2009; 5: e1000539).
----------------
http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.100...
ken
MoSn
paste it again.
"Insanity: doing the same thing over and over again and expecting different
results. " Albert Einstein.
ironjustice
Next time you post you should try that .. that .. just copy and
paste it .. bit ..
INCLUDE the post you are posting to ..
THAT way everyone knows what you are talking about ..
Otherwise you look like some rambling fool ..
Can't have you looking like some rambling fool .. around here ..
That behavior is reserved for alt.atheism ..
ken
> On Nov 20, 10:38 am, MoSn <mosn...@gmail.com> wrote:
> just copy and paste it again. <<
Rusty the Spamming Canuck Parrotbrain
ironjustice
Dental and medical x-rays cause heart disease, new research discovers
<<
Radioprotective effects of exogenous glutathione against whole-body γ-
ray
irradiation: Age- and gender-related changes in malondialdehyde
levels,
superoxide dismutase and catalase activities in rat liver
INAL M. E. (1) ; AKGÜN A. (1) ; KAHRAMAN A. (2) ;
(1) Department of Biochemistry, The Medical School,
Osmangazi University, Eskisehir, TURQUIE
(2) Afyon Kocatepe University, Afyon, TURQUIE
Abstract
Age- and gender-related changes in malondialdehyde (MDA) levels,
superoxide dismutase (SOD) and catalase (CAT) activities in rat
livers
exposed to different doses of whole-body γ-ray radiation were
determined.
In addition, the effects of exogenous glutathione (GSH) against
radiation
injury in rat livers were investigated.
We found that MDA levels have an age-associated increment and an
increasing radiation dose-related elevation. although they decrease
slightly
in the 4 Gy group.
The MDA levels in old rats were lower in males than in females, while
those
of young rats did not change.
There were no observed age-related changes in SOD activities,
although
male rats had higher SOD activity than females.
Female rats had the highest CAT activities in the 4 Gy group, while
male
rats had the highest CAT activities in the 6 Gy group.
CAT activities in the 8 Gy group were lower than those of the 2 Gy
group
for each gender and age.
While MDA levels were decreased and CAT activities increased by GSH.
SOD activities remained unchanged.
The results indicate that γ-ray radiation affects gender- and age-
dependent
MDA levels, SOD and CAT activities.
Administration of GSH appears to be a useful approach to reduce
radiation
injury by reducing MDA levels and increasing CAT activities.
Methods and findings in experimental and clinical pharmacology
ISSN 0379-0355
2002, vol. 24, no4, pp. 209-212 (16 ref.)
Prous, Barcelona, ESPAGNE (1979) (Revue)
INIST-CNRS, Cote INIST : 18217, 35400010153451.0040
-----
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
> Published on Saturday, October 31, 2009
> by Healthy News Service
>
> Low-dose radiation from medical and dental x-rays could cause heart
> disease, a new study suggests.
> Researchers from Imperial College London say they started researching
> a possible connection after numerous studies had shown that workers
> exposed to long-term doses of radiation, such as in the nuclear
> industry, had far higher levels of heart disease.
>
> From this, the research team have drawn a mathematical model to
> suggest
> that people who have medical and dental x-rays could face similar
> risks.
> Radiation kills monocytes, which mop up a protein called MCP-1.
> High levels of the protein are thought to cause inflammation that, in
> turn,
> triggers cardiovascular disease.
>
> Research team leader Dr Mark Little says the model suggests that risks
> from
> x-rays may have been “substantially underestimated”.
>
> (Source: PLOS Computational Biology, 2009; 5: e1000539).
>
> ----------------
>
> http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.100...
Ken
ironjustice
Radioprotective effects of exogenous glutathione <<
http://www.medscape.com/viewarticle/712832
Dietary Supplement May Protect Against Acetaminophen-Induced
Liver Toxicity
Jacquelyn K. Beals, PhD
November 20, 2009 — (SMM)S-methyl methionine , synthesized only
in plants, is present in many foods, including wheat and cabbage,
and is a normal constituent of the human diet.
S-methyl methionine (SMM)converts into methionine, which is
then used in glutathione synthesis.
-----
Dietary S-Methylmethionine, a Component of Foods,
Has Choline-Sparing Activity in Chickens1
Nathan R. Augspurger2, Colleen S. Scherer,
Timothy A. Garrow and David H. Baker3
Departments of Animal Sciences and Food Science and
Human Nutrition, and Division of Nutritional Sciences,
University of Illinois at Urbana-Champaign, Urbana, IL 61801
E-mail: dhb...@uiuc.edu.
Acid hydrolysis of dehulled soybean meal (SBM) and corn
gluten meal (CGM) followed by chromatographic amino acid
analysis (ninhydrin detection) revealed substantial quantities
of S-methylmethionine (SMM) in both ingredients (1.65 g SMM/kg
SBM; 0.5 g SMM/kg CGM).
Young chicks were used to quantify the methionine- (Met) and
choline-sparing bioactivity of crystalline L-SMM, relative to
L-Met and choline chloride standards in 3 assays.
A soy isolate basal diet was developed that could be made
markedly deficient in Met, choline, or both.
When singly deficient in choline or in both choline and Met,
dietary SMM addition produced a significant (P < 0.01) growth
response.
In Assay 2, dietary SMM did not affect (P > 0.10) growth of
chicks fed a Met-deficient, choline-adequate diet.
A standard-curve growth assay revealed choline bioactivity
values (wt:wt) of 14.2 ± 0.8 and 25.9 ± 5.1 g/100 g SMM based
on weight gain and gain:food responses, respectively.
A fourth assay, using standard-curve procedures, showed choline
bioactivity values of 20.1 ± 1.1 and 22.9 ± 1.7 g/100 g SMM
based on weight gain and gain:food responses, respectively.
It is apparent that SMM in foods and feeds has methylation
bioactivity, and this has implications for proper assessment
of dietary Met and choline requirements as well as their
bioavailability in foods and feeds.
Who loves ya.
Tom
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk- Hide quoted text -
>
> - Show quoted text -