Iron Chelating Antibiotic For Parasites
ironjustice
Doxycycline Shows Efficacy Against M. Perstans
NEW YORK (Reuters Health) Oct 07 -
Doxycycline is effective against infection with the filarial parasite
Mansonella perstans, according to results of study conducted in Mali
and reported October 8th in The New England Journal of Medicine.
M. perstans, found primarily throughout sub-Saharan Africa, northern
South America and the Caribbean islands, is refractory to standard
antifilarial therapies.
As Dr. Yaya I. Coulibaly of the University of Bamako in Mali and
colleagues recently found, however, M. perstans parasites harbor
bacteria of the genus Wolbachia - and prior studies have shown that
doxycycline (200 mg/daily for 4 to 8 weeks) decreases the development,
embryogenesis, fertility and viability of filarial worm species that
harbor wolbachia.
Therefore, in 216 patients from four villages in Mali with M. perstans
microfilaremia, the researchers conducted an open-label, randomized
trial of the efficacy of doxycycline (200 mg/daily for 6 weeks)
compared to no treatment.
At 6 months, patients who had coinfection with Wuchereria bancrofti, a
causative agent of lymphatic filariasis, were randomly assigned to a
single dose of albendazole (400 mg) and ivermectin (150 mcg/kg of body
weight) or no treatment.
At 12 months, 97% of patients treated with doxycycline only (67 of 69
patients) had no detectable M. perstans microfilariae per 60
microliter of blood, as compared with only 16% of patients in the
control group (10 of 63 patients).
At 36 months, M. perstans microfilaremia remained suppressed in 75% of
patients treated with doxycycline only (48 of 64 subjects), which
suggested to the researchers that the drug has a macrofilaricidal
effect against M. perstans adult worms, as it is known to have against
other filarial species.
Consistent with prior studies, the current study also showed that a
single dose of albendazole-ivermectin is ineffective in reducing M.
perstans microfilaremia.
In an editorial, Dr. Achim Hoerauf, from University Clinic Bonn,
Germany, said this study "is an important step toward a new treatment
for M. perstans but requires confirmation from studies in other
geographic areas where strains containing -- and possibly those not
containing -- wolbachia are present."
"The current findings," the author wrote, "add to the list of human
filarial species that can be treated with greater efficacy by
targeting wolbachia endosymbionts."
N Engl J Med 2009;361:1448-1458,1502-1504.
-----------------------
http://www.gnc.com/health_notes/Drug/Doxycycline.htm
Antimicrob Agents Chemother. 2000 Mar;44(3):763-6. Related Articles,
Links
Iron-chelating activity of tetracyclines and its impact on the
susceptibility of Actinobacillus
actinomycetemcomitans to these antibiotics.
Grenier D, Huot MP, Mayrand D.
Groupe de Recherche en Ecologie Buccale, Faculte de Medecine Dentaire,
Quebec,
Canada. Daniel....@greb.ulaval.ca
Three tetracyclines (tetracycline, doxycycline, and minocycline) were
found to
possess iron-chelating activity in a colorimetric siderophore assay.
Determination of MICs indicated that the activity of doxycycline
against the
periodontopathogen Actinobacillus actinomycetemcomitans was only
slightly
influenced by the presence of an excess of iron that likely saturates
the
antibiotic. On the other hand, the MICs of doxycycline and minocycline
were
significantly lower for A. actinomycetemcomitans cultivated under iron-
poor
conditions than under iron-rich conditions.
PMID: 10681353
--------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
ironjustice
"The antibiotic doxycycline possesses iron-chelating activity." <<
"Virtually all activity was m-chlorocresol included as a
preservative"
http://www.medkb.com/Uwe/Forum.aspx/med/13646/Taken-For-Phytol-Ride
Two Malaria Drugs for Travelers Have Fewer Side Effects
Released: 9/29/2009 4:10 PM EDT
Embargo expired: 10/6/2009 7:00 PM EDT
Source: Health Behavior News Service
Newswise — A new review of existing research finds that a combination
drug and the common antibiotic doxycycline allow travelers to fend off
malaria with the fewest side effects in areas where the parasite is
resistant to a widely accepted preventive treatment.
Another drug, mefloquine, has the most side effects, but it might be
appropriate for people who already have taken it without problems, the
review authors write.
Doctors must make decisions by relying on a variety of factors, and
the review does not suggest that any one approach is better than
another, said lead review author Dr. Frederique Jacquerioz, a
researcher with Tulane University’s Center for Evidence-based Global
Health.
“The main message is that you have to take some malaria
chemoprophylaxis [preventive treatment] if you go to an endemic area,”
she said. “It’s one of the best preventive measures we have.”
Malaria is present in more than 100 countries and is especially
dangerous in many tropical countries. Travelers should be especially
cautious when they go to more remote areas, Jacquerioz said.
“It really depends how you travel,” she said. “If you stay in the
capital in a four-star hotel and have air conditioning, you’re really
less at risk.”
However, the situation is entirely different if you backpack in rural
areas, she said.
An estimated 10,000 to 30,000 travelers develop malaria infections
each year, according to the World Health Organization. Of those,
researchers estimate that 150 will die.
The authors of the new review say the number of cases is skyrocketing
due to increasing travel to tropical locales. In many cases, the
preferred antimalarial drug, called chloroquine, does not work because
the malaria parasite has developed resistance to it since the 1950s.
Jacquerioz and a colleague analyzed existing research to determine the
possible risks of alternative medications.
They found eight studies, with 4,240 participants that fit their
review criteria.
The review appears in the latest issue of The Cochrane Library, a
publication of the Cochrane Collaboration, an international
organization that evaluates medical research. Systematic reviews draw
evidence-based conclusions about medical practice after considering
both the content and quality of existing medical trials on a topic.
The review authors found that two medications — the combo drug
atovaquone-proguanil and doxycycline — had about the same level of
side effects, although researchers said the studies were not of high
quality.
Compared to a third drug, mefloquine, atovaquone-proguanil had fewer
gastrointestinal and neuropsychiatric side effects, which include
nightmares and dizziness. Doxycycline also had fewer neuropsychiatric
side effects.
The eight studies found no severe side effects — fatal, life
threatening or requiring hospitalization — among those who took the
drugs.
The researchers also looked beyond the review studies to examine
medical literature for mentions of case reports of deaths associated
with normal use of the drugs. There were no reports of deaths
connected to any of the drugs except mefloquine, which had a
connection to 22 deaths, including five suicides.
The researchers caution that the number could be artificially high
because publicity over the drug's safety might make it more likely
that individuals are linking the deaths to the medication.
“There is a big controversy about whether we should use [the drug] or
not, and in which populations,” Jacquerioz said.
The review, she said, does not provide data on safety to support or
oppose mefloquine’s use.
Dr. Andrea Boggild of Toronto General Hospital’s Tropical Disease Unit
said mefloquine is appropriate in some cases, although it does indeed
cause nightmares, insomnia and irritability.
“It is important to remember that severe neuropsychiatric adverse
events are rare and probably occur on the order of one in 6,000 to one
in 10,000 people taking mefloquine,” Boggild said. “In people who have
previously taken mefloquine and tolerated it, there is no reason not
to use it.”
The drug is inexpensive, easy to take and “an attractive choice for
many, many travelers,” Boggild said. The drug’s price is between that
of generic doxycycline, at about $10 to $15 for the required doses for
a 14-day trip, and atovaquone-proguanil at $110 to $120.
Both Jacquerioz and Boggild emphasized the importance of getting
professional advice before going on a trip to a potentially dangerous
area.
“Travelers, whether they are going for business, tourism, missionary
work or to visit friends and relatives, should seek pre-travel advice
from a dedicated travel medicine specialist,” Boggild said. “They
should be aware that no antimalarial drug is 100 percent effective at
preventing malaria, and medical attention should be sought immediately
if fever develops in the risk area while traveling or after a person
returns home.”
The Cochrane Library (http://www.thecochranelibrary.com) contains high
quality health care information, including Systematic Reviews from The
Cochrane Collaboration. These reviews bring together research on the
effects of health care and are considered the gold standard for
determining the relative effectiveness of different interventions. The
Cochrane Collaboration is an international nonprofit, independent
organization that produces and disseminates systematic reviews of
health care interventions and promotes the search for evidence in the
form of clinical trials and other studies of interventions. Visit
http://www.cochrane.org for more information.
Jacquerioz FA, Croft AM. Drugs for preventing malaria in travellers.
Cochrane Database of Systematic Reviews 2009, Issue 4.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
>
> Canada. Daniel.Gren...@greb.ulaval.ca
Happy Oyster
wrote:
>On Oct 9, 8:30�am, ironjustice <ironjust...@rock.com> wrote:
> "The antibiotic doxycycline possesses iron-chelating activity." <<
That is crap.
An antibioticum is an antibioticum, and as such it is meant to kill bacteriae.
--
"Hurenweiberenkelkinder * Gott verst��t die Kindeskinder
hasst der Herrgott auch nicht minder. * von Huren(5.Buch Mose,Kap.23)
Dies gilt auch f�r Ammoniter *
und die miesen Moabiter." * http://www.reimbibel.de
Happy Oyster
wrote:
>"The antibiotic doxycycline possesses iron-chelating activity."
That is a double. Can't you count to 2?
Existential Angst
news:93suc5piai4rcgphg...@4ax.com...
> On Fri, 9 Oct 2009 09:18:50 -0700 (PDT), ironjustice
> <ironj...@rock.com>
> wrote:
>
>>On Oct 9, 8:30 am, ironjustice <ironjust...@rock.com> wrote:
>> "The antibiotic doxycycline possesses iron-chelating activity." <<
>
> That is crap.
>
> An antibioticum is an antibioticum, and as such it is meant to kill
> bacteriae.
There is no law that says an antibiotic can't chelate.
See http://en.wikipedia.org/wiki/Doxycycline for the structure, and
compare with
http://en.wikipedia.org/wiki/Edta .
Scroll down to Coordination chemistry to see how a metal ion is liganded by
edta.
Altho doxycycline is indeed short on carboxyl groups, there's plenty else
there to do the job -- AND, it may take two molecules of the doxy to
"sandwich" an iron ion.
Also, iron, as a transition metal, is much more complicated than typical
chelate-ees, such as Ca2+, capable of Fe1+, 2+, and 3+ states, so it
probably is more versatile ito chelating possibilities.
Not saying it IS an iron chelator, but it certainly could be.
--
EA
Happy Oyster
<UNfi...@UNoptonline.net> wrote:
>"Happy Oyster" <happy....@ariplex.com> wrote in message
>news:93suc5piai4rcgphg...@4ax.com...
>> On Fri, 9 Oct 2009 09:18:50 -0700 (PDT), ironjustice
>> <ironj...@rock.com>
>> wrote:
>>
>>>On Oct 9, 8:30 am, ironjustice <ironjust...@rock.com> wrote:
>>> "The antibiotic doxycycline possesses iron-chelating activity." <<
>>
>> That is crap.
>>
>> An antibioticum is an antibioticum, and as such it is meant to kill
>> bacteriae.
>
>There is no law that says an antibiotic can't chelate.
There is no use for that. Especially not with respect to "ironjustice"s strange
ideas.
--
Bettina Raddatz:
"Treu & Glauben, Hinter den Kulissen eines Wirtschaftsskandals"
http://www.ariplex.com/ama/ama_treu.htm
Existential Angst
> On Fri, 9 Oct 2009 13:50:38 -0400, "Existential Angst"
> <UNfi...@UNoptonline.net> wrote:
>
>>"Happy Oyster" <happy....@ariplex.com> wrote in message
>>news:93suc5piai4rcgphg...@4ax.com...
>>> On Fri, 9 Oct 2009 09:18:50 -0700 (PDT), ironjustice
>>> <ironj...@rock.com>
>>> wrote:
>>>
>>>>On Oct 9, 8:30 am, ironjustice <ironjust...@rock.com> wrote:
>>>> "The antibiotic doxycycline possesses iron-chelating activity." <<
>>>
>>> That is crap.
>>>
>>> An antibioticum is an antibioticum, and as such it is meant to kill
>>> bacteriae.
>>
>>There is no law that says an antibiotic can't chelate.
>
> There is no use for that. Especially not with respect to "ironjustice"s
> strange
> ideas.
No use for what? Iron chelation? Antibiotics that chelate? Chelation in
general?
Probably iron chelation is not as useful as calcium chelation, as Ca is in
fact integrated into damaged tissue, and its removal via chelation could, in
principle, be a part of the repair process. But, iron chelation is
inneresting, nonetheless, from a variety of povs.
Ironjustice indeed seems to have a singular jihad against, well, iron, but
it's not without some rationale.
Note the, uh, irony that perhaps the most heralded nutrient since WW I,
iron, has been recognized as a significant culprit in CVD and proly a bunch
of other things. Punnily ironic, eh?
Now, how significant?
So significant that even the effingAMA has had to recognize it, and you know
they need an effing log in their collective eyes before they even start to
tear.
So significant, that the DRI/ RDA for iron has been lowered, to almost half
the 1989 RDA.
The key is, of course, not to take supplements with iron, period, unless for
a specific reason.
The other key is to recognize that God gave us Vit C to aid in the
absorption of iron, not anticipating that we'd be effing tail-gating BBQ'ing
assaholic obsessed carnivores, with 72 oz steaks in Texas.
IOW, eat a very low-meat diet, take yer C.
The last point is, understanding more about chelation of any element can
lead to more understanding about the chelation of specific elements of
interest, for possibly better therapies.
--
EA
Happy Oyster
<UNfi...@UNoptonline.net> wrote:
>The key is, of course, not to take supplements with iron, period, unless for
>a specific reason.
... and not to try to chelate it. I got a cry for help from a man who had nearly
killed himself because some irresponsible persons had published material about
"detoxing":
http://www.ariplex.com/ama/amabb007.htm
<quote>
Betroffene berichten
"Leben" mit Amalgam-Vergiftung
- und andere Dinge im Umgang mit �rzten -
7
6.1.2002
*
(A20106)
Allzuleicht verlassen sich Kranke auf Behauptungen Anderer. Manche bezahlen
diese Gutgl�ubigkeit mit dem Leben.
Gerade noch mit dem Leben davongekommen, aber schwerkrank ist der arme Mann, der
mir erlaubt hat, seine Bitte um Hilfe zu ver�ffentlichen.
Falls jemand etwas wei�, das ihm helfen kann: BITTE MELDEN SIE SICH!
Ill people too often believe in what others say. Many pay for this with their
life.
Having survived but severly ill, a poor man sent me this email and allowed me to
publish his request for help.
If someone knows something which might help: PLEASE CONTACT ME VIA EMAIL!
d e c k e r s @ a r i p l e x . c o m
Aribert Deckers
DMSA and the DMSA-Hg complex half-life, and the normal values.
Date: Sun, 8 Jul 2001
Hi!
I was looking for S. Emerson's old page - and found your mirror. If you know his
present e-mail address please forward that message quoted below to him.
I would also be grateful if you would reply to that letter as well. Thank you!
(Name)
------- Forwarded message follows -------
Hi!
I hope that you remeber my e-mail from October 1999. I am sorry for such a
long silence, but the enormity of the disasters in my family in recent years
is just incredible.
I lost finaly my job due to the illness, and I got cerebral haemorhage on the
1st of June 2000 - for four weeks doctors were not sure if I survive, but I am
still alive as you see.
I got that cerebral haemorrage during taking of DMSA. Who knows maybe it
was involved in it? I found on that page http://www.altcorp.com/hgtoxicity.htm
an information that DMSA can cause thrombocystosis. I was taking DMSA
produced by Fluka as a chemical reagent (>98% pure). Medical pills of DMSA
were rather too expensive for me.
I felt worse than usually when taking DMSA - is that normal reaction?
I keep my urine samples (gathered when taking DMSA) frozen in photografic
film plastic containers.
I would like to measure Hg level in it, but they (a lab in Lodz, Poland)
want to charge me for every container as for completely separated analysis,
so I have to choose just a few samples (3 or maybe 5 samples) for analysis
to reduce my expenses. They would measure it by AAS cold vapours technique.
I don't know what is metabolism and half-life of DMSA and DMSA-Hg complex
in our organisms, so I am not sure which samples to choose for analysis.
Maybe you could help me? I am attaching a word file with a table indicating
when and how much DMSA I took, and when urine samples were taken. On
the last page in that file is also a copy of my CAT scan.
Do you know what values of Hg are considered normal and what high in urine
*when taking DMSA*? I would be grateful if you would provide me with that
data.
I am now on 1 year of temporary pension due to the cerebral heamorrahage,
though I have been already not able to work earlier due to Hg vapours
poisoning in the lab with severe CFIDS/ME like symptoms. This year also my
grandmother had a stroke (we don't even know for sure whether that was a
bleeding stroke or not, because doctors here stint on doing CAT scans or MRI
for elderly people), and she became left side paralysed. My mother is also
not well, having very strong headaches. We both being ill have to take care
alone about my paralysed grandmother - it is very exhausting, and often we
also cannot sleep at night because of her (she often doesn't sleep all night
long talking often without much sense to herself - that's another result of
the stroke). Doctors here are not helpful at all, they would rather want us
all to die, so that we would not bother them again. And what are the
conditions and treatment in our hospitals is a subject for yet another long
horror story.
We just live in hell on Earth.
We would like to move out from here to another country, but that's not easy
without any help from outside.
I'll better finish here.
Hope to hear from you soon.
Best wishes
[Name)
------ End of forwarded message -------
*
hier geht's weiter !
[ Das Amalgam-Zentrum ]
Copyright � 2000 - 2002
Aribert Deckers
and
Copyright � 2000 - 2002
Antares Real-Estate
Jegliche Weiterverwendung der Texte der Amalgam-Page ist verboten.
Verlage d�rfen sich wegen der Nachdruckrechte per Email an mich wenden.
Aribert Deckers
</quote>
ironjustice
You shteating atheist btches have been told to fkff ..
DOOOOO .. it ..
ALL you shteating atheist btches have been found to be repugnant ..
"The antibiotic doxycycline possesses iron-chelating activity."
Doxycycline Shows Efficacy Against M. Perstans
Happy Oyster
wrote:
>I think you shteating atheist btches were told ..
You think? Prove it!
--
Interview mit dem Autor der "Reimbibel"
Kultur und Wissen
Ausl�ser war der Besuch von Benedikt XVI. in Auschwitz-Birkenau
http://www.nrhz.de/flyer/beitrag.php?id=14183
chorl...@gmail.com
> On Mon, 12 Oct 2009 07:35:52 -0700 (PDT), ironjustice <ironjust...@rock.com>
> wrote:
>
> >I think you shteating atheist btches were told ..
>
> You think? Prove it!
> --
> Interview mit dem Autor der "Reimbibel"
> Kultur und Wissen
I really wish there were some way to slap "IronJustice" silly...
that's you Rusty...
Because you are an idiot with a community college education, you don't
realise that chelation of iron by Doxycycline changes the three
dimensional shape of the doxycycline and it no longer becomes
effective as an antibiotic...
That's why the PI information tells you not to take it with Iron/
Calcium etc.
But chelation is a magic word in pseudo-medicine.
Ironjustice has a deep personality disorder or Bipolar manic phase.
But I would still slap him silly given the chance.
David ( a real doctor)
ironjustice
"The antibiotic doxycycline possesses iron-chelating activity."
<<
Piperidones with activity against Plasmodium falciparum. [JOURNAL
ARTICLE]
Parasitol Res 2006 Mar 21.
Saeftel M, Sarite RS, Njuguna T, Holzgrabe U, Ulmer D, Hoerauf A,
Kaiser A
The increasing resistance of the malaria parasites has enforced new
strategies of finding new drug targets. We have isolated two genes
involved in spermidine metabolism, encoding deoxyhypusine synthase
(DHS) and eukaryotic initiation factor 5A (eIF-5A) in the malaria
parasites. eIF-5A is activated by the formation of the unusual amino
acid hypusine. This process occurs in two steps. DHS transfers an
aminobutyl moiety from the triamine spermidine to a specific lysine
residue in the eIF-5A precursor protein to form deoxyhypusine. In a
second step, deoxyhypusine hydroxylase (DHH), completes hypusine
biosynthesis. We used DHH inhibitors, being effective in mammalian
cells, to study an antiplasmodicidal effect in Plasmodium falciparum.
Experiments with the antifungal drug ciclopiroxolamine, an alpha-
hydroxypyridone, and the plant amino acid L: -mimosine, a 4-pyridone,
resulted in an antiplasmodial effect in vitro. Using mimosine as a
lead structure, alkyl 4-oxo-piperidine 3-carboxylates were found to
have the most efficient antiplasmodial effects in vitro and in vivo.
--------------------------------------------------------------------------------
More from this journal
Parasitol Res
---------
Who loves ya.
Tom
Jan Drew
"Virtually all activity was m-chlorocresol included as a
ironjustice
"The antibiotic doxycycline possesses iron-chelating activity."
<<
Effects of bisphosphonates on the growth of Entamoeba
histolytica and Plasmodium species in vitro and in vivo.
Ghosh S, Chan JM, Lea CR, Meints GA, Lewis JC, Tovian ZS,
Flessner RM, Loftus TC, Bruchhaus I, Kendrick H, Croft SL,
Kemp RG, Kobayashi S, Nozaki T, Oldfield E
J Med Chem 2004 Jan 1; 47(1):175-87.
The effects of a series of 102 bisphosphonates on the
inhibition of growth of Entamoeba histolytica and
Plasmodium falciparum in vitro have been determined,
and selected compounds were further investigated for
their in vivo activity.
Forty-seven compounds tested were active (IC(50)
< 200 microM) versus E. histolytica growth in vitro.
The most active compounds (IC(50) approximately 4-9
microM) were nitrogen-containing bisphosphonates with
relatively large aromatic side chains.
Simple n-alkyl-1-hydroxy-1,1-bisphosphonates, known
inhibitors of the enzyme farnesylpyrophosphate (FPP)
synthase, were also active, with optimal activity
being found with C9-C10 side chains.
However, numerous other nitrogen-containing
bisphosphonates known to be potent FPP synthase
inhibitors, such as risedronate or pamidronate, had
little or no activity.
Several pyridine-derived bisphosphonates were quite
active (IC(50) approximately 10-20 microM), and this
activity was shown to correlate with the basicity of
the aromatic group, with activity decreasing with
increasing pK(a) values.
The activities of all compounds were tested versus a
human nasopharyngeal carcinoma (KB) cell line to enable
an estimate of the therapeutic index (TI).
Five bisphosphonates were selected and then screened for
their ability to delay the development of amebic liver
abscess formation in an E. histolytica infected hamster
model.
Two compounds were found to decrease liver abscess
formation at 10 mg/kg ip with little or no effect on
normal liver mass.
With P. falciparum, 35 compounds had IC(50) values
<200 microM in an in vitro assay.
The most active compounds were also simple
n-alkyl-1-hydroxy-1,1-bisphosphonates, having IC(50)
values around 1 microM.
Five compounds were again selected for in vivo
investigation in a Plasmodium berghei ANKA BALB/c mouse
suppressive test.
The most active compound, a C9 n-alkyl side chain containing
bisphosphonate, caused an 80% reduction in parasitemia with
no overt toxicity.
Taken together, these results show that bisphosphonates
appear to be useful lead compounds for the development of
novel antiamebic and antimalarial drugs.
Journal of medicinal chemistry. [J Med Chem]
---------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
>
> Piperidones with activity against Plasmodium falciparum. [JOURNAL
> ARTICLE]
> Parasitol Res 2006 Mar 21.
> Saeftel M, Sarite RS, Njuguna T, Holzgrabe U, Ulmer D, Hoerauf A,
> Kaiser A
>
> The increasing resistance of the malaria parasites has enforced new
> strategies of finding new drug targets. We have isolated two genes
> involved in spermidine metabolism, encoding deoxyhypusine synthase
> (DHS) and eukaryotic initiation factor 5A (eIF-5A) in the malaria
> parasites. eIF-5A is activated by the formation of the unusual amino
> acid hypusine. This process occurs in two steps. DHS transfers an
> aminobutyl moiety from the triamine spermidine to a specific lysine
> residue in the eIF-5A precursor protein to form deoxyhypusine. In a
> second step, deoxyhypusine hydroxylase (DHH), completes hypusine
> biosynthesis. We used DHH inhibitors, being effective in mammalian
> cells, to study an antiplasmodicidal effect in Plasmodium falciparum.
> Experiments with the antifungal drug ciclopiroxolamine, an alpha-
> hydroxypyridone, and the plant amino acid L: -mimosine, a 4-pyridone,
> resulted in an antiplasmodial effect in vitro. Using mimosine as a
> lead structure, alkyl 4-oxo-piperidine 3-carboxylates were found to
> have the most efficient antiplasmodial effects in vitro and in vivo.
>
> --------------------------------------------------------------------------------
> More from this journal
> Parasitol Res
> ---------
>
> Who loves ya.
> Tom
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk- Hide quoted text -
>
> - Show quoted text -
Jan Drew
wrote:
> "Happy Oyster" <happy.oys...@ariplex.com> wrote in message
>
> news:93suc5piai4rcgphg...@4ax.com...
>
> > On Fri, 9 Oct 2009 09:18:50 -0700 (PDT), ironjustice
> > wrote:
>
> >>On Oct 9, 8:30 am, ironjustice <ironjust...@rock.com> wrote:
> >> "The antibiotic doxycycline possesses iron-chelating activity." <<
>
> > That is crap.
>
> > An antibioticum is an antibioticum, and as such it is meant to kill
> > bacteriae.
>
> There is no law that says an antibiotic can't chelate.
>
> See �http://en.wikipedia.org/wiki/Doxycycline�for the structure, and
http://en.wikipedia.org/wiki/Wikipedia:General_disclaimer
http://en.wikipedia.org/wiki/Wikipedia:Risk_disclaimer
http://en.wikipedia.org/wiki/Wikipedia:Medical_disclaimer
Jan Drew
[ ]
Jan Drew
The web address you entered could not be found
Peter Bowditch
>On Oct 10, 1:58?pm, Happy Oyster <happy.oys...@ariplex.com> wrote:
> http://www.altcorp.com/hgtoxicity.htm
>
>The web address you entered could not be found
>
That's right, Jan. All of Boyd Haley's insane web sites have been down
for a long time. It must be really hurting his pocket now that he
can't advertise his fraudulent testing and chelation services.
--
Peter Bowditch aa #2243
The Millenium Project http://www.ratbags.com/rsoles
Australian Council Against Health Fraud http://www.acahf.org.au
To email me use my first name only at ratbags.com
PeterB - Original
wrote:
>
Impressive logic. Why do you post so rarely to mha?
fer...@paris.com
So what, so does aspirin. To what larger body of thought should this be
applied and why should we care beyond its apparent use?