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Iron In Periodontitis

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ironjustice

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Dec 9, 2021, 3:45:37 AM12/9/21
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High serum iron markers are associated with periodontitis in postmenopausal women: a population-based study (NHANES III)
Susilena Arouche Costa 1, Cecilia Claudia Costa Ribeiro 2, Ana Regina Oliveira Moreira 3, Soraia de Fátima Carvalho Souza 4
J Clin Periodontol
. 2021 Dec 8. doi: 10.1111/jcpe.13580.\

Abstract
Aim: To investigate the association between increased serum markers of iron (ferritin and transferrin saturation) and the severity and extent of periodontitis in postmenopausal women.

Methods: Data from 982 postmenopausal women participating in NHANES III were analyzed. Exposures were high ferritin (≥ 300 μg/mL) and transferrin saturation (≥45%). The primary outcome was moderate/severe periodontitis defined according to Centers for Disease Control and Prevention and the American Academy of Periodontology. The extent of periodontitis was also assessed as outcome: proportion of sites affected by clinical attachment loss ≥4 mm and probing depth ≥ 4 mm. Crude and adjusted Prevalence Ratio (PR) and Mean Ratio (MR) were estimated using Poisson Regression.

Results: The prevalence of moderate/severe periodontitis was 27.56%. High ferritin was associated with moderate/severe periodontitis in the crude (PR 1.55, p = 0.018) and in the final adjusted model (PR 1.53, p = 0.008). High ferritin and transferrin saturation levels were associated with a higher proportion of sites with clinical attachment loss ≥4 mm (p < 0.05).

Conclusion: The increasing serum iron markers seem to contribute to periodontitis severity and extent in postmenopausal women.

PMID: 34879443 DOI: 10.1111/jcpe.13580

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