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Phytate Intake In Insulin Sensitivity Daily phytate intake increases adiponectin levels among patients with diabetes type 2: a randomized crossover trial Randomized Controlled Trial Nutr Diabetes. 2023 Feb 28;13(1):2. Pilar Sanchis 1 2 3, Paula Calv
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ironjustice
Mar 7, 2023, 7:39:34 AM3/7/23
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Daily phytate intake increases adiponectin levels among patients with diabetes type 2: a randomized crossover trial
Randomized Controlled Trial Nutr Diabetes. 2023 Feb 28;13(1):2.
Pilar Sanchis 1 2 3, Paula Calvo 4 5, Antelm Pujol 6, Rosmeri Rivera 6, Francisco Berga 4 5, Regina Fortuny 6, Antonia Costa-Bauza 4 5, Felix Grases 4 5, Luis Masmiquel 7
PMID: 36854678 PMCID: PMC9975181 DOI: 10.1038/s41387-023-00231-9
Free PMC article
Abstract
Aim: Adiponectin, a major adipokine secreted by adipose tissue, has been shown to improve insulin sensitivity. Myo-inositol hexaphosphate (phytate; InsP6) is a natural compound that is abundant in cereals, legumes, and nuts that has demonstrated to have different beneficial properties in patients with diabetes type 2.
Methods: We performed a randomized crossover trial to investigate the impact of daily consumption of InsP6 on serum levels of adiponectin, TNF-alpha, IL-6, and IL-1beta in patients with type 2 diabetes mellitus (T2DM; n = 39). Thus, we measure serum levels of these inflammatory markers, classic vascular risk factors, and urinary InsP6 at baseline and at the end of the intervention period.
Results: Patients who consumed InsP6 supplements for 3 months had higher levels of adiponectin and lower HbA1c than those who did not consume InsP6. No differences were found in TNF-alpha, IL-6, and IL-1beta.
Conclusion: This is the first report to show that consumption of InsP6 increases plasma adiponectin concentration in patients with T2DM. Consequently, our findings indicate that following a phytate-rich diet has beneficial effects on adiponectin and HbA1c concentrations and it could help to prevent or minimize diabetic-related complications.
© 2023. The Author(s).
Phytate is 'natures premiere iron chelator', used by some to lower their iron levels, IP6.
Eating soy lowers those iron level markers, but ONLY if the phytate has been left in the food / soy.
“Soy protein with native phytate significantly reduced tHcy (P = 0.017), transferrin saturation (P = 0.027), and ferritin (P = 0.029), whereas soy protein with native isoflavones had no effect on any variables.”
https://pubmed.ncbi.nlm.nih.gov/17023703/
"When the same subjects, that are following a low phytate diet, went onto normal phytate diet, a rise of plasma phytate was produced at 15 days"
http://litiasisrenal.uib.es/3inform/fitato/2Ang/fitatTa.html
“It seems that reduced insulin sensitivity in meat-eaters is amenable to improvement by reducing body Fe”
https://www.ncbi.nlm.nih.gov/pubmed/11591239
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
Randomized Controlled Trial Nutr Diabetes. 2023 Feb 28;13(1):2.
Pilar Sanchis 1 2 3, Paula Calvo 4 5, Antelm Pujol 6, Rosmeri Rivera 6, Francisco Berga 4 5, Regina Fortuny 6, Antonia Costa-Bauza 4 5, Felix Grases 4 5, Luis Masmiquel 7
PMID: 36854678 PMCID: PMC9975181 DOI: 10.1038/s41387-023-00231-9
Free PMC article
Abstract
Aim: Adiponectin, a major adipokine secreted by adipose tissue, has been shown to improve insulin sensitivity. Myo-inositol hexaphosphate (phytate; InsP6) is a natural compound that is abundant in cereals, legumes, and nuts that has demonstrated to have different beneficial properties in patients with diabetes type 2.
Methods: We performed a randomized crossover trial to investigate the impact of daily consumption of InsP6 on serum levels of adiponectin, TNF-alpha, IL-6, and IL-1beta in patients with type 2 diabetes mellitus (T2DM; n = 39). Thus, we measure serum levels of these inflammatory markers, classic vascular risk factors, and urinary InsP6 at baseline and at the end of the intervention period.
Results: Patients who consumed InsP6 supplements for 3 months had higher levels of adiponectin and lower HbA1c than those who did not consume InsP6. No differences were found in TNF-alpha, IL-6, and IL-1beta.
Conclusion: This is the first report to show that consumption of InsP6 increases plasma adiponectin concentration in patients with T2DM. Consequently, our findings indicate that following a phytate-rich diet has beneficial effects on adiponectin and HbA1c concentrations and it could help to prevent or minimize diabetic-related complications.
© 2023. The Author(s).
Phytate is 'natures premiere iron chelator', used by some to lower their iron levels, IP6.
Eating soy lowers those iron level markers, but ONLY if the phytate has been left in the food / soy.
“Soy protein with native phytate significantly reduced tHcy (P = 0.017), transferrin saturation (P = 0.027), and ferritin (P = 0.029), whereas soy protein with native isoflavones had no effect on any variables.”
https://pubmed.ncbi.nlm.nih.gov/17023703/
"When the same subjects, that are following a low phytate diet, went onto normal phytate diet, a rise of plasma phytate was produced at 15 days"
http://litiasisrenal.uib.es/3inform/fitato/2Ang/fitatTa.html
“It seems that reduced insulin sensitivity in meat-eaters is amenable to improvement by reducing body Fe”
https://www.ncbi.nlm.nih.gov/pubmed/11591239
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
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