Fatty Liver and Iron Overload

[ironjustice]

A preliminary investigation of the association between haptoglobin
polymorphism, serum ferritin concentration and fatty liver disease.
Nakagawa T, Muramoto Y, Hori M, Mihara S, Marubayashi T, Nakagawa K
Clin Chim Acta 2008 Aug 8.

BACKGROUND:
The genetic polymorphism of haptoglobin (HP) has been associated with
cardiovascular disease and type 2 diabetes. We hypothesized that the
HP polymorphism could affect the incidence of nonalcoholic fatty liver
disease (NAFLD).
METHODS:
This cross sectional case-control analysis included 337 Japanese
participants in a health screening program. Fatty liver disease (FLD)
was diagnosed by ultrasonography scanning and was classified into
NAFLD based on the daily alcohol intake. The HP(1) and HP(2) alleles
were determined using the PCR, and serum ferretin concentrations were
measured.
RESULTS:
FLD and NAFLD were diagnosed in 91 and 69 subjects, respectively. The
adjusted odd ratio (OR) of HP(2) carriers vs. non-carriers was 11.8
[95% CI, 1.3-104.0] for FLD, and 11.7 (95% CI, 1.3-107.9) for NAFLD.
Male FLD cases with the HP(2)/HP(2)genotype had significantly higher
ferretin concevntrations than those without (P=0.003). The ferritin
concentrations were correlated with the alanine-aminotransferase
activities (r=0.48, P<0.001 in FLD cases with the HP(2)/HP(2)
genotype). Ferritin was an independent risk factor for FLD, and the
incidence of FLD significantly increased in association with
ferritin.
CONCLUSIONS:
This is a preliminary but the first report suggesting the HP(2) allele
to be a candidate risk factor for NAFLD.

Clinica chimica acta; international journal of clinical chemistry
[Clin Chim Acta]
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