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Iron In HIV
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ironjustice
May 17, 2013, 11:47:06 AM5/17/13
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Role of cellular iron and oxygen in the regulation of HIV-1
infection.
Nekhai S, Kumari N, Dhawan S
Future Virol 2013; 8(3):301-311
Abstract
Despite efficient antiretroviral therapy, eradication of HIV-1
infection is challenging and requires novel biological insights and
therapeutic strategies.
Among other physiological and environmental factors, intracellular
iron greatly affects HIV-1 replication.
Higher iron stores were shown to be associated with faster progression
of HIV-1 infection and to inversely correlate with the survival of
HIV-1 infected patients.
Iron is required for several steps in the HIV-1 life cycle, including
reverse transcription, HIV-1 gene expression and capsid assembly.
Here, the authors present a comprehensive review of the molecular
mechanisms involved in iron- and oxygen-mediated regulation of HIV-1
replication.
We also propose key intracellular pathways that may be involved in
regulating HIV-1 replication, via protein kinase complexes, CDK9/
cyclin T1 and CDK 2/cyclin E, protein phosphatase-1 and other host
factors.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
infection.
Nekhai S, Kumari N, Dhawan S
Future Virol 2013; 8(3):301-311
Abstract
Despite efficient antiretroviral therapy, eradication of HIV-1
infection is challenging and requires novel biological insights and
therapeutic strategies.
Among other physiological and environmental factors, intracellular
iron greatly affects HIV-1 replication.
Higher iron stores were shown to be associated with faster progression
of HIV-1 infection and to inversely correlate with the survival of
HIV-1 infected patients.
Iron is required for several steps in the HIV-1 life cycle, including
reverse transcription, HIV-1 gene expression and capsid assembly.
Here, the authors present a comprehensive review of the molecular
mechanisms involved in iron- and oxygen-mediated regulation of HIV-1
replication.
We also propose key intracellular pathways that may be involved in
regulating HIV-1 replication, via protein kinase complexes, CDK9/
cyclin T1 and CDK 2/cyclin E, protein phosphatase-1 and other host
factors.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/4rq595
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
montygraham
May 17, 2013, 10:27:09 PM5/17/13
to
reality of the situation !
John H. Gohde
May 18, 2013, 4:53:05 AM5/18/13
to
except "iron."
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