Lycopene Versus Fluvastatin
ironjustice
induced by a high-fat diet in rabbits
Nutrition, Volume 24, Issue 10, October 2008, Pages 1030-1038
Min-Yu Hu, Yi-Lin Li, Chong-He Jiang, Zhao-Qian Liu, Shu-Lin Qu, Yi-
Ming Huang
Objective
We evaluated the antiatherogenic effect of lycopene in rabbits fed a
high-fat diet.
Methods
Forty adult male rabbits were divided into five groups that were fed a
standard diet, a high-fat diet, a high-fat diet plus 4 mg/kg of
lycopene, a high-fat diet plus 12 mg/kg of lycopene, and a high-fat
diet plus 10 mg/kg of fluvastatin, respectively. Lycopene and
fluvastatin were administered intragastrically.
The level of serum total cholesterol, total triglyceride, high-density
lipoprotein cholesterol, low-density lipoprotein cholesterol, total
antioxidant capacity, and malondialdehyde were measured before and
after 4 and 8 wk of experimental treatment.
In addition, plasma levels of lycopene, oxidized low-density
lipoprotein, serum nitric oxide, and interleukin-1 were measured after
the experiment.
The area of atherosclerotic plaque and pathologic changes of the aorta
were evaluated.
Results
Compared with the control, levels of total cholesterol, total
triacylglycerol, low-density lipoprotein cholesterol, malonaldehyde,
oxidized low-density lipoprotein, and interleukin-1 were increased and
total antioxidant capacity and nitric oxide were decreased in the
animals with a high-fat diet (P < 0.05).
Intragastric administration of lycopene counteracted the change in
these parameters (P < 0.05).
In this case, the data showed that lycopene in the used dose was
better than the fluvastatin intervention.
Morphologic analysis revealed that lycopene and fluvastatin markedly
reduced the formation of atherosclerotic plaques in the aorta compared
with the situation in rabbits on a high-fat diet alone.
Conclusion
Lycopene, like fluvastatin, significantly attenuated atherogenesis in
rabbits fed a high-fat diet.
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